Vigil Neuroscience Inc (VIGL)

Vigil Neuroscience Stock (VIGL) dropped by 40.03% from $6.67 to $4.00 in the trading on Friday November 17, 2023. The reason why VIGL stock down today is due to the interim data from its Phase 2 IGNITE proof-of-concept clinical trial in patients with ALSP. The data, representing the first six patients following six months of treatment with 20 mg/kg of iluzanebart, supports the drug's safety and tolerability, and showed target engagement and downstream pharmacological activity, consistent with Phase 1 data. Directionally supportive changes were observed on MRI and NfL biomarkers of disease progression in individual patients, and the company expects to report full Phase 2 IGNITE results in Q3 2024.