20.47
price up icon0.05%   0.010
pre-market  Pre-market:  20.67   0.20   +0.98%
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Denali Therapeutics Inc stock is traded at $20.47, with a volume of 2.25M. It is up +0.05% in the last 24 hours and down -15.41% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$20.46
Open:
$20.4
24h Volume:
2.25M
Relative Volume:
1.39
Market Cap:
$3.27B
Revenue:
$1.27M
Net Income/Loss:
$-508.02M
P/E Ratio:
-7.1059
EPS:
-2.8807
Net Cash Flow:
$-419.23M
1W Performance:
+1.69%
1M Performance:
-15.41%
6M Performance:
-2.38%
1Y Performance:
+51.85%
1-Day Range:
Value
$19.73
$20.64
1-Week Range:
Value
$19.40
$21.79
52-Week Range:
Value
$13.14
$27.30

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
507
Name
Twitter
Name
Next Earnings Date
2026-11-05
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, MRNA, ARGX, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
DNLI icon
DNLI
Denali Therapeutics Inc
20.47 3.27B 1.27M -508.02M -419.23M -2.8807
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
522.38 132.40B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
796.02 81.95B 14.92B 4.42B 3.79B 41.04
MRNA icon
MRNA
Moderna Inc
194.82 77.78B 2.23B -3.19B -1.60B -8.1462
ARGX icon
ARGX
Argen X Se Adr
962.22 60.20B 4.16B 1.29B 734.26M 19.58
RVMD icon
RVMD
Revolution Medicines Inc
199.86 42.84B 742.00K -1.37B -1.07B -7.0731

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-26-26 Reiterated H.C. Wainwright Buy
Feb-24-26 Initiated Wolfe Research Peer Perform
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
View All

Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
Sep 18, 2026

Denali Therapeutics Stock Price Forecast. Should You Buy DNLI? - StockInvest.us

Sep 18, 2026
pulisher
Sep 17, 2026

SK Biopharm takes 1st Bio’s LRRK2/c-Abl inhibitor in $315M deal - BioWorld News

Sep 17, 2026
pulisher
Sep 17, 2026

Transcript : Denali Therapeutics Inc. Presents at 12th Annual Cantor Fitzgerald Global Healthcare Conference, Sep-09-2026 09 - marketscreener.com

Sep 17, 2026
pulisher
Sep 14, 2026

DNLI: AVLAYAH's launch validates a brain-targeted biologics platform, driving pipeline and global expansion - TradingView

Sep 14, 2026
pulisher
Sep 14, 2026

Denali Therapeutics at Morgan Stanley conference: launch momentum builds By Investing.com - Investing.com Canada

Sep 14, 2026
pulisher
Sep 10, 2026

The Technical Signals Behind (DNLI) That Institutions Follow - Stock Traders Daily

Sep 10, 2026
pulisher
Sep 09, 2026

Denali at Cantor global healthcare conference: launch gains traction By Investing.com - Investing.com India

Sep 09, 2026
pulisher
Sep 09, 2026

Denali Therapeutics (DNLI) Institutional Ownership 2026 $DNLI - MarketBeat

Sep 09, 2026
pulisher
Sep 08, 2026

Denali Therapeutics Insider Transactions: Officer Peter Scott Chin to Sell 1,654 Shares, Director Nancy Thornberry Sells 11,439 Shares (NASDAQ: DNLI) - Kalkine Media

Sep 08, 2026
pulisher
Sep 05, 2026

Denali Therapeutics director sells $261,928 in stock - Investing.com

Sep 05, 2026
pulisher
Sep 05, 2026

Denali Therapeutics director sells $261,928 in stock By Investing.com - Investing.com South Africa

Sep 05, 2026
pulisher
Sep 04, 2026

Denali Therapeutics (NASDAQ: DNLI) holder to sell shares to cover tax on stock units - Stock Titan

Sep 04, 2026
pulisher
Sep 04, 2026

Denali Therapeutics Director Nancy Thornberry Executes Two Stock Sales Under Rule 10b5-1 Plan - Kalkine Media

Sep 04, 2026
pulisher
Sep 04, 2026

Denali Therapeutics Insider Sold Shares Worth $261,929, According to a Recent SEC Filing - marketscreener.com

Sep 04, 2026
pulisher
Sep 02, 2026

Director Nancy Thornberry plans Denali (NASDAQ: DNLI) stock sale - Stock Titan

Sep 02, 2026
pulisher
Sep 01, 2026

Denali Therapeutics (NASDAQ: DNLI) exec plans 2,768-share Rule 144 sale - stocktitan.net

Sep 01, 2026
pulisher
Aug 25, 2026

B. Riley Adjusts Denali Therapeutics Price Target to $35 From $30, Maintains Buy Rating - finance.yahoo.com

Aug 25, 2026
pulisher
Aug 24, 2026

Denali (DNLI) Session: Finishes 2.89% Lower at $24.20; Technical View: Price Remains Between $22.99 Support and $25.41 ResistanceOBV Trend Line - vinanet.vn

Aug 24, 2026
pulisher
Aug 21, 2026

Denali Therapeutics (DNLI) Q2 2026 Earnings Call Transcript - AOL.com

Aug 21, 2026
pulisher
Aug 21, 2026

145,045 Shares in Denali Therapeutics Inc. $DNLI Purchased by Great Lakes Advisors LLC - MarketBeat

Aug 21, 2026
pulisher
Aug 20, 2026

Denali’s DNL921 Trial: Early Alzheimer’s Safety Data That Could Shape Long-Term Upside - TipRanks

Aug 20, 2026
pulisher
Aug 20, 2026

DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock? - TradingView

Aug 20, 2026
pulisher
Aug 20, 2026

Edmond DE Rothschild Holding S.A. Invests $4.25 Million in Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 20, 2026
pulisher
Aug 19, 2026

Denali (DNLI) Financial Update: The Available Earnings Metric Delivers a Miss for This Review; Market Reaction: Shares Finish 3.25% UpDividend Increase Stocks - vinanet.vn

Aug 19, 2026
pulisher
Aug 19, 2026

Denali Therapeutics: Bullish On AVLAYAH And Their Prospects (NASDAQ:DNLI) - Seeking Alpha

Aug 19, 2026
pulisher
Aug 19, 2026

Bank of America Corp DE Boosts Stock Position in Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 19, 2026
pulisher
Aug 18, 2026

Denali Therapeutics (DNLI) Could Be 42% Undervalued Following Its Earnings Report - Sahm

Aug 18, 2026
pulisher
Aug 17, 2026

SCS Capital Management LLC Takes Position in Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 17, 2026
pulisher
Aug 14, 2026

Denali Therapeutics CEO Ryan J. Watts Donates 32,220 Shares to Donor Advised Fund - Kalkine Media

Aug 14, 2026
pulisher
Aug 14, 2026

Denali Therapeutics Inc.: Fundamental Analysis and Financial Ratings | DNLI | US24823R1059 - marketscreener.com

Aug 14, 2026
pulisher
Aug 13, 2026

Denali Therapeutics (NASDAQ:DNLI) Insider Sells $71,624.99 in Stock - MarketBeat

Aug 13, 2026
pulisher
Aug 13, 2026

Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One (NASDAQ:DNLI) - Seeking Alpha

Aug 13, 2026
pulisher
Aug 13, 2026

Sei Investments Co. Purchases Shares of 52,235 Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 13, 2026
pulisher
Aug 11, 2026

J.P. Morgan Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Maintains Target Price $29 - Moomoo

Aug 11, 2026
pulisher
Aug 11, 2026

Equities Analysts Set Expectations for DNLI Q3 Earnings - MarketBeat

Aug 11, 2026
pulisher
Aug 11, 2026

E. Ohman J or Asset Management AB Acquires New Shares in Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 11, 2026
pulisher
Aug 11, 2026

Denali Therapeutics (DNLI) holder to sell 2,857 restricted shares via broker - Stock Titan

Aug 11, 2026
pulisher
Aug 10, 2026

Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June R - GuruFocus

Aug 10, 2026
pulisher
Aug 10, 2026

Weekly Recap: Q2 revenue, big net loss and DNL126 Phase 3 with 2027 BLA - TradingView

Aug 10, 2026
pulisher
Aug 10, 2026

Denali climbs past Avlayah expectations with $3.6M in revenue - BioSpace

Aug 10, 2026
pulisher
Aug 09, 2026

(DNLI) Movement Within Algorithmic Entry Frameworks - Stock Traders Daily

Aug 09, 2026
pulisher
Aug 09, 2026

The Manufacturers Life Insurance Company Lowers Stock Holdings in Denali Therapeutics Inc. $DNLI - MarketBeat

Aug 09, 2026
pulisher
Aug 08, 2026

Denali Therapeutics (NASDAQ:DNLI) Posts Earnings Results, Misses Estimates By $0.17 EPS - MarketBeat

Aug 08, 2026
pulisher
Aug 08, 2026

A Quick Look at Today's Ratings for Denali Therapeutics(DNLI.US), With a Forecast Between $31 to $42 - Moomoo

Aug 08, 2026
pulisher
Aug 08, 2026

Denali Therapeutics (DNLI) Is Up 7.9% After AVLAYAH Launch Drives First Full-Quarter Commercial Revenue - Sahm

Aug 08, 2026
pulisher
Aug 08, 2026

Denali Therapeutics Inc. (NASDAQ:DNLI) Given Average Rating of "Moderate Buy" by Analysts - MarketBeat

Aug 08, 2026
pulisher
Aug 08, 2026

Denali Therapeutics (NASDAQ:DNLI) Stock Rating Upgraded by Wall Street Zen - MarketBeat

Aug 08, 2026
pulisher
Aug 07, 2026

DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum - Yahoo Finance

Aug 07, 2026
pulisher
Aug 07, 2026

UBS Adjusts Price Target on Denali Therapeutics to $34 From $25, Maintains Buy Rating - marketscreener.com

Aug 07, 2026
pulisher
Aug 07, 2026

Denali Therapeutics Inc. Stock 12‑Month Price Target Raised to $35.44, Implies 43% Upside - TradingView

Aug 07, 2026
pulisher
Aug 07, 2026

A Quick Look at Today's Ratings for Denali Therapeutics(DNLI.US), With a Forecast Between $31 to $41 - Moomoo

Aug 07, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$58.29
price up icon 1.11%
$36.13
price down icon 1.87%
$121.55
price up icon 2.71%
$249.59
price up icon 1.25%
ONC ONC
$359.97
price down icon 1.38%
$199.86
price up icon 4.78%
Cap:     |  Volume (24h):