21.68
price up icon7.54%   1.52
after-market After Hours: 21.75 0.07 +0.32%
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Denali Therapeutics Inc stock is traded at $21.68, with a volume of 1.88M. It is up +7.54% in the last 24 hours and up +5.40% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$20.16
Open:
$20.24
24h Volume:
1.88M
Relative Volume:
1.09
Market Cap:
$3.44B
Revenue:
$1.27M
Net Income/Loss:
$-512.54M
P/E Ratio:
-7.3019
EPS:
-2.9691
Net Cash Flow:
$-422.10M
1W Performance:
+10.50%
1M Performance:
+5.40%
6M Performance:
+32.92%
1Y Performance:
+64.62%
1-Day Range:
Value
$20.20
$21.71
1-Week Range:
Value
$18.96
$21.71
52-Week Range:
Value
$12.31
$23.77

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
503
Name
Twitter
Name
Next Earnings Date
2025-08-08
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
DNLI icon
DNLI
Denali Therapeutics Inc
21.68 3.20B 1.27M -512.54M -422.10M -2.9691
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
441.70 113.01B 12.07B 3.95B 3.19B 15.33
REGN icon
REGN
Regeneron Pharmaceuticals Inc
753.93 79.87B 14.34B 4.50B 3.77B 41.56
ARGX icon
ARGX
Argen X Se Adr
840.87 51.51B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
333.39 45.29B 3.71B 313.75M 465.38M 2.2571
ONC icon
ONC
Beone Medicines Ltd Adr
319.94 34.41B 5.36B 287.73M 924.18M 2.5229

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-26-26 Reiterated H.C. Wainwright Buy
Feb-24-26 Initiated Wolfe Research Peer Perform
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
View All

Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
Apr 14, 2026

FDA clears Denali Therapeutics drug as first brain-penetrating biologic for rare disease - MSN

Apr 14, 2026
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Apr 13, 2026

Retail Surge: Can Denali Therapeutics Inc withstand a market correction2026 Drop Watch & Low Risk Profit Maximizing Plans - baoquankhu1.vn

Apr 13, 2026
pulisher
Apr 13, 2026

Pullback Watch: Is Denali Therapeutics Inc stock suitable for long term investingQuarterly Trade Report & Smart Money Movement Tracker - baoquankhu1.vn

Apr 13, 2026
pulisher
Apr 11, 2026

Assessing Denali Therapeutics (DNLI) Valuation After Recent Share Pullback And Pipeline Growth Expectations - Sahm

Apr 11, 2026
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Apr 11, 2026

Pullback Watch: Can Denali Therapeutics Inc withstand a market correctionMarket Activity Summary & Community Verified Swing Trade Signals - baoquankhu1.vn

Apr 11, 2026
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Apr 10, 2026

Retail Surge: What are analysts price targets for Denali Therapeutics IncPrice Action & Risk Controlled Swing Alerts - baoquankhu1.vn

Apr 10, 2026
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Apr 09, 2026

Trading the Move, Not the Narrative: (DNLI) Edition - Stock Traders Daily

Apr 09, 2026
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Apr 09, 2026

How AVLAYAH’s Accelerated Approval and Takeda Exit Will Impact Denali Therapeutics (DNLI) Investors - Sahm

Apr 09, 2026
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Apr 08, 2026

Aug Opening: Is Denali Therapeutics Inc forming higher highs and higher lowsGap Down & Daily Volume Surge Signals - baoquankhu1.vn

Apr 08, 2026
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Apr 08, 2026

Analysts Offer Insights on Healthcare Companies: Denali Therapeutics (DNLI) and Fennec Pharmaceuticals (FENC) - The Globe and Mail

Apr 08, 2026
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Apr 08, 2026

Arista Networks To Rally Around 43%? Here Are 10 Top Analyst Forecasts For Tuesday - Sahm

Apr 08, 2026
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Apr 07, 2026

Denali Stock Falls as Partner Takeda Ends Collaboration Deal - Yahoo Finance

Apr 07, 2026
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Apr 07, 2026

H.C. Wainwright Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Maintains Target Price $42 - Moomoo

Apr 07, 2026
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Apr 07, 2026

Denali Therapeutics (NASDAQ:DNLI) Given New $34.00 Price Target at Robert W. Baird - MarketBeat

Apr 07, 2026
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Apr 07, 2026

Denali shares drop after Takeda terminates partnership agreement - Bitget

Apr 07, 2026
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Apr 07, 2026

Denali regains rights to DNL593 from Takeda - The Pharma Letter

Apr 07, 2026
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Apr 06, 2026

BTIG Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Raises Target Price to $39 - Moomoo

Apr 06, 2026
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Apr 06, 2026

Denali Therapeutics (NASDAQ:DNLI) Shares Down 4.9%Here's What Happened - MarketBeat

Apr 06, 2026
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Apr 06, 2026

Takeda Exits Dementia Drug Partnership With Denali TherapeuticsHere's Why - Benzinga

Apr 06, 2026
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Apr 06, 2026

Takeda Breaks Up With Denali, Dumps Dementia Drug - BioSpace

Apr 06, 2026
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Apr 06, 2026

Capricorn Fund Managers Ltd Acquires New Position in Denali Therapeutics Inc. $DNLI - MarketBeat

Apr 06, 2026
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Apr 06, 2026

Denali Regains Full Control Of DNL593 As It Advances Toward Key 2026 Readout - RTTNews

Apr 06, 2026
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Apr 05, 2026

Takeda (TAK) Ends Collaboration on Drug Development with Denali Therapeutics - GuruFocus

Apr 05, 2026
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Apr 05, 2026

SG Americas Securities LLC Increases Stock Position in Denali Therapeutics Inc. $DNLI - MarketBeat

Apr 05, 2026
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Apr 05, 2026

Denali Therapeutics Inc. $DNLI Stake Increased by Aberdeen Group plc - MarketBeat

Apr 05, 2026
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Apr 05, 2026

Denali Therapeutics Inc. (NASDAQ:DNLI) Receives Average Rating of "Moderate Buy" from Analysts - marketbeat.com

Apr 05, 2026
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Apr 04, 2026

DNLI Financials: Revenue Breakdown, Margins & Competitor Comparison - Intellectia AI

Apr 04, 2026
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Apr 04, 2026

DNLI Technical Analysis & Stock Price Forecast - Intellectia AI

Apr 04, 2026
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Apr 04, 2026

Denali Reclaims DNL593 Rights Concentrating Dementia Drug Risks And Upside - Sahm

Apr 04, 2026
pulisher
Apr 03, 2026

Denali Therapeutics Inc. (DNLI) stock price, news, quote and history - Yahoo Finance Singapore

Apr 03, 2026
pulisher
Apr 03, 2026

Denali Regains DNL593 Rights After Takeda Collaboration Ends - TipRanks

Apr 03, 2026
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Apr 03, 2026

Denali Therapeutics Regains Full Rights to DNL593 as Takeda Ends 2018 Collaboration - TradingView

Apr 03, 2026
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Apr 03, 2026

Denali Therapeutics Inc. And Takeda Terminate Collaboration Agreement For DNL593 - marketscreener.com

Apr 03, 2026
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Apr 03, 2026

Takeda exits DNL593 deal; Denali (NASDAQ: DNLI) takes full control of FTD-GRN drug - Stock Titan

Apr 03, 2026
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Apr 03, 2026

Denali Therapeutics Regains Full Rights to Investigational Therapy DNL593 (PTV:PGRN) for GRN-related Frontotemporal Dementia (FTD-GRN) - The Manila Times

Apr 03, 2026
pulisher
Apr 03, 2026

Takeda exits dementia drug pact, Denali targets trial data by 2026 end - Stock Titan

Apr 03, 2026
pulisher
Apr 02, 2026

Aug Opening: Is Denali Therapeutics Inc a turnaround storyQuarterly Market Review & Community Verified Trade Alerts - baoquankhu1.vn

Apr 02, 2026
pulisher
Apr 02, 2026

DNLI Stock Price, Quote & Chart | DENALI THERAPEUTICS INC (NASDAQ:DNLI) - ChartMill

Apr 02, 2026
pulisher
Apr 01, 2026

Biopharma M&A Heats Up, Rare Diseases Win Three Approvals, Wave Crashes - BioSpace

Apr 01, 2026
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Apr 01, 2026

Market Overview: Will Denali Therapeutics Inc outperform small cap indexesQuarterly Market Review & Weekly High Return Opportunities - baoquankhu1.vn

Apr 01, 2026
pulisher
Mar 31, 2026

Pullback Watch: Will Denali Therapeutics Inc benefit from government policy2026 AllTime Highs & Capital Protection Trade Alerts - baoquankhu1.vn

Mar 31, 2026
pulisher
Mar 31, 2026

The $578 Billion Regenerative Medicine Market Has a Manufacturing Problem. One Company Just Solved the First Step - Benzinga

Mar 31, 2026
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Mar 31, 2026

Denali Therapeutics Receives $200 Million Following FDA Accelerated Approval of Tividenofusp Alfa and Royalty Agreement Closing - minichart.com.sg

Mar 31, 2026
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Mar 31, 2026

Denali Therapeutics scores $200 million shortly after first drug approval - The Business Journals

Mar 31, 2026
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Mar 31, 2026

Denali Therapeutics Secures $200 Million Royalty Funding - TipRanks

Mar 31, 2026
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Mar 31, 2026

Denali Therapeutics receives $200 million from royalty agreement after FDA approval - Investing.com India

Mar 31, 2026
pulisher
Mar 31, 2026

Denali Therapeutics (NASDAQ: DNLI) closes $200M royalty deal after FDA OK - Stock Titan

Mar 31, 2026
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Mar 30, 2026

Denali Therapeutics (DNLI) Is Down 13.9% After First BBB-Crossing Hunter Therapy Wins FDA NodWhat's Changed - Yahoo Finance

Mar 30, 2026
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Mar 29, 2026

Is Denali Therapeutics’ (DNLI) First Brain-Penetrant Biologic Redefining Its Platform Value Proposition? - simplywall.st

Mar 29, 2026
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Mar 29, 2026

(DNLI) Volatility Zones as Tactical Triggers - Stock Traders Daily

Mar 29, 2026
pulisher
Mar 27, 2026

Denali Therapeutics Inc. (DNLI) Discusses FDA Approval and Commercial Launch Plans for AVLAYAH for Hunter SyndromeSlideshow (NASDAQ:DNLI) 2026-03-27 - Seeking Alpha

Mar 27, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$54.26
price up icon 2.69%
$48.70
price down icon 0.25%
$99.47
price up icon 1.08%
$152.54
price up icon 3.76%
$146.74
price down icon 4.34%
ONC ONC
$319.94
price up icon 3.21%
Cap:     |  Volume (24h):