21.93
price down icon1.31%   -0.29
after-market After Hours: 21.85 -0.08 -0.36%
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Denali Therapeutics Inc stock is traded at $21.93, with a volume of 1.44M. It is down -1.31% in the last 24 hours and up +17.78% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$22.22
Open:
$22.12
24h Volume:
1.44M
Relative Volume:
0.81
Market Cap:
$3.48B
Revenue:
$1.27M
Net Income/Loss:
$-508.02M
P/E Ratio:
-7.6127
EPS:
-2.8807
Net Cash Flow:
$-419.23M
1W Performance:
+5.48%
1M Performance:
+17.78%
6M Performance:
+28.85%
1Y Performance:
+50.00%
1-Day Range:
Value
$21.68
$22.47
1-Week Range:
Value
$20.16
$22.47
52-Week Range:
Value
$12.58
$23.77

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
507
Name
Twitter
Name
Next Earnings Date
2026-05-05
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
DNLI icon
DNLI
Denali Therapeutics Inc
21.93 3.53B 1.27M -508.02M -419.23M -2.8807
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
453.17 114.33B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
614.73 64.47B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
878.49 54.99B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
281.90 38.42B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
156.58 34.03B 742.00K -1.37B -1.07B -7.0731

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-26-26 Reiterated H.C. Wainwright Buy
Feb-24-26 Initiated Wolfe Research Peer Perform
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
View All

Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
Jun 14, 2026

(DNLI) and the Role of Price-Sensitive Allocations - Stock Traders Daily

Jun 14, 2026
pulisher
Jun 12, 2026

Denali Therapeutics (DNLI) Rallies Over 3% as Stock Tests Key Resistance LevelsStock Analysis - newsline.com

Jun 12, 2026
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Jun 11, 2026

What Makes Denali Therapeutics (DNLI) One of the Best AI Driven Biotech Names - Insider Monkey

Jun 11, 2026
pulisher
Jun 11, 2026

10 Best AI Driven Biotech Stocks to Invest In - Insider Monkey

Jun 11, 2026
pulisher
Jun 10, 2026

LRRK2 inhibitor failure pushes Parkinson’s field toward genetic enrichment - BioCentury

Jun 10, 2026
pulisher
Jun 08, 2026

Denali Therapeutics stock (US24823R1077): Alzheimer’s data and Roche deal keep Wall Street watchin - AD HOC NEWS

Jun 08, 2026
pulisher
Jun 06, 2026

Denali stock dips as Biogen-partnered Parkinson's disease study fails - MSN

Jun 06, 2026
pulisher
Jun 05, 2026

Denali Therapeutics (DNLI) grants RSUs and stock options to director - Stock Titan

Jun 05, 2026
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Jun 05, 2026

Denali Therapeutics (DNLI) director granted RSUs and options in new award - Stock Titan

Jun 05, 2026
pulisher
Jun 05, 2026

Denali Therapeutics (DNLI) director receives RSU and stock option awards - Stock Titan

Jun 05, 2026
pulisher
Jun 05, 2026

Director at Denali Therapeutics (NASDAQ: DNLI) receives RSUs and options - Stock Titan

Jun 05, 2026
pulisher
Jun 05, 2026

Denali Therapeutics (DNLI) director receives new RSU and stock option grants - Stock Titan

Jun 05, 2026
pulisher
Jun 05, 2026

Denali Therapeutics (DNLI) director granted RSUs and stock options in new equity awards - Stock Titan

Jun 05, 2026
pulisher
Jun 05, 2026

Denali Therapeutics (NASDAQ: DNLI) details Baker RSU and stock option grants - Stock Titan

Jun 05, 2026
pulisher
Jun 03, 2026

Denali Therapeutics (DNLI) 2026 meeting backs board slate, auditor and executive pay - Stock Titan

Jun 03, 2026
pulisher
Jun 03, 2026

Responsive Playbooks and the DNLI Inflection - Stock Traders Daily

Jun 03, 2026
pulisher
Jun 02, 2026

DNLI PE Ratio & Valuation, Is DNLI Overvalued - Intellectia AI

Jun 02, 2026
pulisher
Jun 01, 2026

DNLI.O Technical Analysis & Stock Price Forecast - Intellectia AI

Jun 01, 2026
pulisher
Jun 01, 2026

Denali Therapeutics Inc. (DNLI): One of the Top Stock Picks of Jeff Bezos - Insider Monkey

Jun 01, 2026
pulisher
Jun 01, 2026

Does Denali Therapeutics (DNLI) Parkinson’s Setback Reveal a Deeper Shift in Its Neuroscience Strategy? - simplywall.st

Jun 01, 2026
pulisher
May 31, 2026

DNLI Earning Date, Earning Analysis and Earning Prediction - Intellectia AI

May 31, 2026
pulisher
May 31, 2026

DNLI Q1 loss narrower than expected, Avlayah approval boosts prospects - MSN

May 31, 2026
pulisher
May 30, 2026

A Look At Denali Therapeutics (DNLI) Valuation After Phase 2b Trial Failure Refocuses Attention On Its Pipeline - Sahm

May 30, 2026
pulisher
May 29, 2026

Biogen and Denali halt BIIB122 trial for idiopathic Parkinson’s - Parkinson's News Today

May 29, 2026
pulisher
May 29, 2026

DNLI gains 25.4% year to date: Should you buy, sell or hold the stock? - MSN

May 29, 2026
pulisher
May 28, 2026

Privium Fund Opens $5.07 Million Denali Stake Ahead of FDA Drug Approval - AOL.com

May 28, 2026
pulisher
May 27, 2026

Denali Therapeutics: 'Strong Buy' On AVLAYAH Approval And End Of 2026 FTD-GRN Data - Seeking Alpha

May 27, 2026
pulisher
May 26, 2026

Morgan Stanley Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Maintains Target Price $35 - Moomoo

May 26, 2026
pulisher
May 26, 2026

Denali Therapeutics' Focus Shifts to Other Pipeline Assets After Phase 2b Study Failure, Morgan Stanley Says - Moomoo

May 26, 2026
pulisher
May 26, 2026

DNLI Maintained by Morgan Stanley -- Price Target Lowered to $35 - GuruFocus

May 26, 2026
pulisher
May 25, 2026

Biogen and Denali discontinue Parkinson’s candidate BIIB122 after Phase IIb LUMA study miss - Manufacturing Chemist

May 25, 2026
pulisher
May 24, 2026

Biogen, Denali to drop Parkinson’s therapy after mid-stage trial setback - MSN

May 24, 2026
pulisher
May 24, 2026

A Quick Look at Today's Ratings for Denali Therapeutics(DNLI.US), With a Forecast Between $31 to $42 - Moomoo

May 24, 2026
pulisher
May 23, 2026

Understanding the Setup: (DNLI) and Scalable Risk - Stock Traders Daily

May 23, 2026
pulisher
May 23, 2026

Analysts Are Bullish on Top Healthcare Stocks: Denali Therapeutics (DNLI), Intuitive Surgical (ISRG) - The Globe and Mail

May 23, 2026
pulisher
May 22, 2026

Biogen (BIIB) and Denali (DNLI) Halt Development of BIIB122 Afte - GuruFocus

May 22, 2026
pulisher
May 22, 2026

Is Early AVLAYAH Demand Reshaping The Investment Case For Denali Therapeutics’ Rare-Disease Platform (DNLI)? - Sahm

May 22, 2026
pulisher
May 22, 2026

Biogen Faces Trial Setbacks And Probes That Reframe Neuro Pipeline Risks - Yahoo Finance UK

May 22, 2026
pulisher
May 22, 2026

Biogen and Denali Halt Development of BIIB122 After Phase 2b LUMA Study Fails in Early Parkinson’s Disease - Minichart

May 22, 2026
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May 22, 2026

Morgan Stanley Cuts Price Target on Denali Therapeutics to $35 From $40, Keeps Overweight Rating - Moomoo

May 22, 2026
pulisher
May 22, 2026

Denali Stock Dips as Biogen-Partnered Parkinson's Disease Study Fails - Yahoo Finance

May 22, 2026
pulisher
May 22, 2026

Deutsche Bank Adjusts Denali Therapeutics Price Target to $31 From $35, Maintains Buy Rating - Moomoo

May 22, 2026
pulisher
May 22, 2026

Denali Therapeutics stock falls after Parkinson’s drug fails trial By Investing.com - Investing.com South Africa

May 22, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$30.41
price up icon 1.27%
$55.40
price up icon 6.27%
$89.50
price down icon 1.43%
$54.21
price down icon 0.11%
ONC ONC
$263.92
price down icon 1.60%
$156.58
price down icon 2.17%
Cap:     |  Volume (24h):