18.64
price down icon3.42%   -0.66
after-market After Hours: 18.60 -0.04 -0.21%
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Denali Therapeutics Inc stock is traded at $18.64, with a volume of 3.47M. It is down -3.42% in the last 24 hours and down -7.95% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$19.30
Open:
$18.52
24h Volume:
3.47M
Relative Volume:
2.00
Market Cap:
$2.96B
Revenue:
$1.27M
Net Income/Loss:
$-512.54M
P/E Ratio:
-6.278
EPS:
-2.9691
Net Cash Flow:
$-422.10M
1W Performance:
+0.11%
1M Performance:
-7.95%
6M Performance:
+3.56%
1Y Performance:
+36.46%
1-Day Range:
Value
$18.18
$19.06
1-Week Range:
Value
$17.71
$19.33
52-Week Range:
Value
$12.58
$23.77

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
507
Name
Twitter
Name
Next Earnings Date
2026-05-05
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
DNLI icon
DNLI
Denali Therapeutics Inc
18.64 3.06B 1.27M -512.54M -422.10M -2.9691
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
434.52 110.03B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
638.88 67.37B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
806.46 50.76B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
297.45 40.12B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
151.56 32.68B 742.00K -1.37B -1.07B -7.0731

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-26-26 Reiterated H.C. Wainwright Buy
Feb-24-26 Initiated Wolfe Research Peer Perform
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
View All

Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
May 25, 2026

Denali stock dips as Biogen-partnered Parkinson's disease study fails - MSN

May 25, 2026
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May 25, 2026

Biogen and Denali discontinue Parkinson’s candidate BIIB122 after Phase IIb LUMA study miss - Manufacturing Chemist

May 25, 2026
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May 24, 2026

Biogen, Denali to drop Parkinson’s therapy after mid-stage trial setback - MSN

May 24, 2026
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May 24, 2026

A Quick Look at Today's Ratings for Denali Therapeutics(DNLI.US), With a Forecast Between $31 to $42 - Moomoo

May 24, 2026
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May 23, 2026

Understanding the Setup: (DNLI) and Scalable Risk - Stock Traders Daily

May 23, 2026
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May 22, 2026

Biogen (BIIB) and Denali (DNLI) Halt Development of BIIB122 Afte - GuruFocus

May 22, 2026
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May 22, 2026

Is Early AVLAYAH Demand Reshaping The Investment Case For Denali Therapeutics’ Rare-Disease Platform (DNLI)? - Sahm

May 22, 2026
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May 22, 2026

Biogen Faces Trial Setbacks And Probes That Reframe Neuro Pipeline Risks - Yahoo Finance UK

May 22, 2026
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May 22, 2026

Biogen and Denali Halt Development of BIIB122 After Phase 2b LUMA Study Fails in Early Parkinson’s Disease - Minichart

May 22, 2026
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May 22, 2026

Morgan Stanley Cuts Price Target on Denali Therapeutics to $35 From $40, Keeps Overweight Rating - Moomoo

May 22, 2026
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May 22, 2026

Denali Stock Dips as Biogen-Partnered Parkinson's Disease Study Fails - Yahoo Finance

May 22, 2026
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May 22, 2026

Deutsche Bank Adjusts Denali Therapeutics Price Target to $31 From $35, Maintains Buy Rating - Moomoo

May 22, 2026
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May 22, 2026

Denali Therapeutics stock falls after Parkinson’s drug fails trial By Investing.com - Investing.com South Africa

May 22, 2026
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May 22, 2026

Denali Therapeutics stock falls after Parkinson’s drug fails trial - Investing.com

May 22, 2026
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May 22, 2026

H.C. Wainwright Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Maintains Target Price $42 - Moomoo

May 22, 2026
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May 22, 2026

Wedbush Cuts Price Target on Denali Therapeutics to $20 From $23, Keeps Outperform Rating - marketscreener.com

May 22, 2026
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May 22, 2026

Biogen, Denali to drop Parkinson’s therapy (BIIB:NASDAQ) - Seeking Alpha

May 22, 2026
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May 22, 2026

Parkinson’s drug from Biogen, Denali comes up short - Yahoo Finance

May 22, 2026
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May 22, 2026

Denali Therapeutics and Biogen discontinue BIIB122 after Phase 2b LUMA misses endpoints - TradingView

May 22, 2026
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May 22, 2026

Biogen, Denali scrap Parkinson’s candidate after Phase IIb miss - The Pharma Letter

May 22, 2026
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May 22, 2026

DNLI Stock Price, Quote & Chart | DENALI THERAPEUTICS INC (NASDAQ:DNLI) - ChartMill

May 22, 2026
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May 22, 2026

Biogen, Denali scrap Parkinson’s drug after failure in mid-to-late stage study - 1470 & 100.3 WMBD

May 22, 2026
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May 22, 2026

Biogen, Denali discontinue Parkinson’s drug after trial fails By Investing.com - Investing.com Nigeria

May 22, 2026
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May 21, 2026

Parkinson’s trial setback: Biogen, Denali halt BIIB122 program, await 2027 data - Stock Titan

May 21, 2026
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May 21, 2026

Biogen and Denali Therapeutics Halt BIIB122 Development After Tr - GuruFocus

May 21, 2026
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May 21, 2026

Biogen, Denali discontinue Parkinson’s drug after trial fails - Investing.com UK

May 21, 2026
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May 21, 2026

BIIB, DNLI Stocks Edge Lower After Hours: Parkinson’s Drug Misses Key Goals In Trial - Yahoo Finance

May 21, 2026
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May 21, 2026

Biogen (BIIB) Halts Development of BIIB122 After Phase 2b Study Results - GuruFocus

May 21, 2026
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May 21, 2026

[8-K] Denali Therapeutics Inc. Reports Material Event - Stock Titan

May 21, 2026
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May 21, 2026

Biogen, Denali scrap Parkinson's drug after failure in mid-to-late stage study - Reuters

May 21, 2026
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May 21, 2026

Biogen and Denali Therapeutics Provide Update on Phase 2b LUMA Study of BIIB122 (DNL151) in Early-Stage Parkinson’s Disease - Biogen

May 21, 2026
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May 21, 2026

Biogen and Denali Therapeutics Provide Update on Phase 2b LUMA Study of BIIB122 (DNL151) in Early-Stage Parkinson’s Disease - GlobeNewswire Inc.

May 21, 2026
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May 21, 2026

Denali Therapeutics stock (US24823R1077): New data keeps biotech in focus - AD HOC NEWS

May 21, 2026
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May 19, 2026

DNLI Q1 loss narrower than expected, Avlayah approval boosts prospects - MSN

May 19, 2026
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May 18, 2026

Hedge Fund Wagers $36 Million on Biotech Denali After First FDA Approval - Yahoo Finance

May 18, 2026
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May 17, 2026

DNLI gains 25.4% year to date: Should you buy, sell or hold the stock? - MSN

May 17, 2026
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May 16, 2026

Denali Therapeutics Says AVLAYAH Launch Ahead of Expectations After Hunter Syndrome Approval - sharewise.com

May 16, 2026
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May 15, 2026

T. Rowe Price holds 5.4% of Denali Therapeutics (NASDAQ: DNLI) - Stock Titan

May 15, 2026
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May 15, 2026

Biogen’s Alzheimer’s results bolster tau theory—and Denali’s next gen candidate - BioSpace

May 15, 2026
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May 14, 2026

FDA clears Denali Therapeutics drug as first brain-penetrating biologic for rare disease - MSN

May 14, 2026
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May 14, 2026

Oligonucleotides Clinical Trial Drug Development Pipeline Expands with Contributions from 200+ Key Companies | DelveInsight - The Manila Times

May 14, 2026
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May 14, 2026

Morgan Stanley Trims Price Target on Denali Therapeutics to $40 From $42, Keeps Overweight Rating - Moomoo

May 14, 2026
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May 14, 2026

Morgan Stanley Maintains Denali Therapeutics(DNLI.US) With Buy Rating, Cuts Target Price to $40 - Moomoo

May 14, 2026
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May 14, 2026

Denali Therapeutics stock (US24823R1077): Takeda exits DNL593 partnership - AD HOC NEWS

May 14, 2026
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May 14, 2026

Number of shareholders of Denali Therapeutics Inc. – SWB:4DN - TradingView

May 14, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$29.96
price down icon 2.98%
$106.24
price down icon 3.00%
$92.14
price up icon 1.33%
$54.50
price up icon 1.77%
ONC ONC
$310.25
price up icon 0.20%
$151.56
price down icon 1.41%
Cap:     |  Volume (24h):