91.41
price down icon3.61%   -3.42
after-market After Hours: 91.41
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Protagonist Therapeutics Inc stock is traded at $91.41, with a volume of 677.48K. It is down -3.61% in the last 24 hours and up +13.31% over the past month. Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.
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Previous Close:
$94.83
Open:
$94.54
24h Volume:
677.48K
Relative Volume:
0.86
Market Cap:
$5.83B
Revenue:
$46.02M
Net Income/Loss:
$-130.15M
P/E Ratio:
-44.75
EPS:
-2.0427
Net Cash Flow:
$56.08M
1W Performance:
+3.42%
1M Performance:
+13.31%
6M Performance:
+51.02%
1Y Performance:
+137.74%
1-Day Range:
Value
$90.35
$94.54
1-Week Range:
Value
$87.31
$95.43
52-Week Range:
Value
$37.92
$96.54

Protagonist Therapeutics Inc Stock (PTGX) Company Profile

Name
Name
Protagonist Therapeutics Inc
Name
Phone
(510) 474-0170
Name
Address
7707 GATEWAY BLVD., SUITE 140, NEWARK, CA
Name
Employee
132
Name
Twitter
Name
Next Earnings Date
2026-02-20
Name
Latest SEC Filings
Name
PTGX's Discussions on Twitter

Compare PTGX vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
PTGX
Protagonist Therapeutics Inc
91.41 6.05B 46.02M -130.15M 56.08M -2.0427
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
460.82 121.40B 12.07B 3.95B 3.19B 15.33
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
764.93 83.25B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
728.11 46.39B 4.16B 1.29B 734.26M 19.59
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
320.51 43.41B 3.71B 313.75M 465.38M 2.2571
Biotechnology icon
ONC
Beone Medicines Ltd Adr
292.94 33.09B 5.36B 287.73M 924.18M 2.5229

Protagonist Therapeutics Inc Stock (PTGX) Upgrades & Downgrades

Date Action Analyst Rating Change
Sep-17-25 Initiated Barclays Overweight
Sep-12-25 Initiated Leerink Partners Outperform
Jun-17-25 Initiated Citigroup Buy
Dec-06-24 Initiated BMO Capital Markets Outperform
Dec-06-24 Initiated Goldman Neutral
Nov-05-24 Initiated Wedbush Outperform
Sep-24-24 Initiated TD Cowen Buy
Sep-09-24 Initiated Truist Buy
Oct-30-23 Initiated CapitalOne Overweight
May-25-23 Resumed Jefferies Buy
Aug-25-22 Initiated JMP Securities Mkt Outperform
Feb-11-22 Initiated BTIG Research Buy
Oct-12-21 Upgrade JP Morgan Neutral → Overweight
Oct-11-21 Upgrade Northland Capital Market Perform → Outperform
Sep-20-21 Downgrade JP Morgan Overweight → Neutral
May-24-21 Initiated JMP Securities Mkt Outperform
May-24-21 Initiated Northland Capital Outperform
Jan-06-21 Initiated JP Morgan Overweight
Dec-16-20 Initiated Piper Sandler Overweight
Sep-18-20 Reiterated H.C. Wainwright Buy
Jul-15-20 Initiated Jefferies Buy
May-18-20 Reiterated H.C. Wainwright Buy
Jul-08-19 Initiated H.C. Wainwright Buy
May-09-19 Upgrade Stifel Hold → Buy
Dec-06-18 Initiated Nomura Buy
Jan-29-18 Initiated Stifel Buy
Jul-21-17 Initiated BTIG Research Buy
View All

Protagonist Therapeutics Inc Stock (PTGX) Latest News

pulisher
Mar 04, 2026

Johnson & Johnson in talks to acquire Protagonist Therapeutics, source says - AOL.com

Mar 04, 2026
pulisher
Mar 04, 2026

Is Protagonist Therapeutics (PTGX) Still Attractive After A 136% One Year Share Price Surge - simplywall.st

Mar 04, 2026
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Mar 04, 2026

JPMorgan Chase & Co. Lowers Stake in Protagonist Therapeutics, Inc. $PTGX - MarketBeat

Mar 04, 2026
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Mar 03, 2026

Protagonist Therapeutics (PTGX) Target Price Raised by Goldman S - GuruFocus

Mar 03, 2026
pulisher
Mar 03, 2026

Protagonist Therapeutics (NASDAQ:PTGX) Price Target Raised to $95.00 - MarketBeat

Mar 03, 2026
pulisher
Mar 03, 2026

Protagonist Therapeutics, Inc. (PTGX) Stock Analysis: Strong Buy Ratings and a Promising 14.42% Upside Potential - DirectorsTalk Interviews

Mar 03, 2026
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Mar 03, 2026

TD Asset Management Inc Acquires 34,096 Shares of Protagonist Therapeutics, Inc. $PTGX - MarketBeat

Mar 03, 2026
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Mar 02, 2026

Wedbush Raises Price Target on Protagonist Therapeutics to $100 From $86, Keeps Outperform Rating - marketscreener.com

Mar 02, 2026
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Mar 02, 2026

Takeda and Protagonist Announce U.S. Food and Drug Administration Accepts New Drug Application and Grants Priority Review for Rusfertide as a Potential First-in-Class Therapy for Polycythemia Vera - lelezard.com

Mar 02, 2026
pulisher
Mar 02, 2026

Takeda Pharmaceutical and Protagonist Therapeutics Inc (NASDAQ: PTGX) jointly announced that the U.S. Food and Drug Administration (FDA) has officially accepted the New Drug Application (NDA) for their co-developed drug Rusfertide and granted it prior - Bitget

Mar 02, 2026
pulisher
Mar 02, 2026

HC Wainwright Has Optimistic Outlook of PTGX Q1 Earnings - MarketBeat

Mar 02, 2026
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Mar 01, 2026

Protagonist Therapeutics, Inc. $PTGX Shares Sold by Vanguard Group Inc. - MarketBeat

Mar 01, 2026
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Mar 01, 2026

Citigroup Inc. Has $10.14 Million Stake in Protagonist Therapeutics, Inc. $PTGX - MarketBeat

Mar 01, 2026
pulisher
Mar 01, 2026

Why Protagonist Therapeutics (PTGX) Is Up 11.3% After Rusfertide NDA And Collaboration Shift - Yahoo Finance

Mar 01, 2026
pulisher
Feb 28, 2026

Protagonist Therapeutics (PTGX) Quarterly Loss Deepens To US$44.4m And Tests Bullish Profitability Narrative - Sahm

Feb 28, 2026
pulisher
Feb 28, 2026

PTGX Stock News Today | Earnings, Events & Price Alerts - Intellectia AI

Feb 28, 2026
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Feb 27, 2026

Protagonist Therapeutics Director Sells 20,000 Shares Amid Strong Stock Performance - AOL.com

Feb 27, 2026
pulisher
Feb 27, 2026

A Glimpse Into The Expert Outlook On Protagonist Therapeutics Through 8 Analysts - Sahm

Feb 27, 2026
pulisher
Feb 27, 2026

Regulatory Turbulence: FDA Disruptions and U.S. Government Shutdown Threaten Protagonist Therapeutics’ Development Timelines - TipRanks

Feb 27, 2026
pulisher
Feb 26, 2026

Understanding the Setup: (PTGX) and Scalable Risk - Stock Traders Daily

Feb 26, 2026
pulisher
Feb 26, 2026

Protagonist Therapeutics (PTGX) Gets Price Target Lift from TD C - GuruFocus

Feb 26, 2026
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Feb 26, 2026

TD Cowen Boosts Protagonist Therapeutics (NASDAQ:PTGX) Price Target to $100.00 - MarketBeat

Feb 26, 2026
pulisher
Feb 26, 2026

PTGX: Today's Analyst Ratings and Price Target Updates | PTGX St - GuruFocus

Feb 26, 2026
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Feb 26, 2026

Protagonist Therapeutics (PTGX) Sees Analyst Rating Update from Barclays | PTGX Stock News - GuruFocus

Feb 26, 2026
pulisher
Feb 26, 2026

Protagonist Therapeutics (NASDAQ:PTGX) Price Target Raised to $113.00 at Barclays - MarketBeat

Feb 26, 2026
pulisher
Feb 26, 2026

Protagonist Therapeutics (NASDAQ:PTGX) Price Target Raised to $112.00 - MarketBeat

Feb 26, 2026
pulisher
Feb 26, 2026

Protagonist Stock Up 120%, but One Fund Just Revealed a $170 Million Exit - AOL.com

Feb 26, 2026
pulisher
Feb 26, 2026

Protagonist Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update - The Desert Sun

Feb 26, 2026
pulisher
Feb 26, 2026

Citizens raises Protagonist Therapeutics stock price target on drug approvals - Investing.com UK

Feb 26, 2026
pulisher
Feb 26, 2026

Decoding Protagonist Therapeutics Inc (PTGX): A Strategic SWOT I - GuruFocus

Feb 26, 2026
pulisher
Feb 25, 2026

CORRECTION: Protagonist Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update - The Register-Guard

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Therapeutics (NASDAQ:PTGX) Posts Earnings Results, Misses Expectations By $0.16 EPS - MarketBeat

Feb 25, 2026
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Feb 25, 2026

Protagonist Therapeutics: Fourth Quarter Earnings Overview - Bitget

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Therapeutics: Protagonist Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update - FinanzNachrichten.de

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Therapeutics Q4 Earnings Summary & Key Takeaways - Benzinga

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Therapeutics Q4 revenue drops on lower milestone payments - TradingView

Feb 25, 2026
pulisher
Feb 25, 2026

Earnings Flash (PTGX) Protagonist Therapeutics, Inc. Reports Q4 Revenue $7.4M - marketscreener.com

Feb 25, 2026
pulisher
Feb 25, 2026

[8-K] Protagonist Therapeutics, Inc Reports Material Event | PTGX SEC FilingForm 8-K - Stock Titan

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Stock Up 120%, but One Fund Just Revealed a $170 Million Exit - The Motley Fool

Feb 25, 2026
pulisher
Feb 25, 2026

Protagonist Therapeutics, Inc. (PTGX) Stock Analysis: A Promising Biotech with 17.7% Upside Potential - DirectorsTalk Interviews

Feb 25, 2026
pulisher
Feb 24, 2026

Protagonist Therapeutics to Participate in Multiple Investment Bank Conferences in March 2026 - ACCESS Newswire

Feb 24, 2026
pulisher
Feb 24, 2026

Protagonist CEO lines up five healthcare investor events for March - Stock Titan

Feb 24, 2026
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Feb 21, 2026

HC Wainwright raises Protagonist Therapeutics, Inc. (PTGX) target to $117, reiterates buy - MSN

Feb 21, 2026
pulisher
Feb 21, 2026

RTW INVESTMENTS, LP Reduces Stake in Protagonist Therapeutics Inc - GuruFocus

Feb 21, 2026
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Feb 20, 2026

Can Protagonist Therapeutics Inc. sustain its profitabilityWeekly Trade Summary & AI Driven Stock Movement Reports - mfd.ru

Feb 20, 2026
pulisher
Feb 20, 2026

Protagonist Therapeutics showcases pioneering peptide technology - Traders Union

Feb 20, 2026
pulisher
Feb 20, 2026

Lewis Williams Sells 18,000 Shares of Protagonist Therapeutics (NASDAQ:PTGX) Stock - Defense World

Feb 20, 2026

Protagonist Therapeutics Inc Stock (PTGX) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Protagonist Therapeutics Inc Stock (PTGX) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Williams Lewis T
Director
Feb 17 '26
Sale
82.42
18,000
1,483,560
7,825
$45.68
price down icon 3.69%
$53.83
price down icon 6.87%
$29.72
price up icon 0.68%
$101.95
price down icon 1.78%
$143.57
price down icon 4.21%
biotechnology ONC
$292.94
price down icon 2.03%
Cap:     |  Volume (24h):