40.97
price up icon1.29%   0.52
after-market After Hours: 40.97
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Sionna Therapeutics Inc stock is traded at $40.97, with a volume of 321.34K. It is up +1.29% in the last 24 hours and up +1.19% over the past month. Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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Previous Close:
$40.45
Open:
$41.53
24h Volume:
321.34K
Relative Volume:
0.92
Market Cap:
$1.85B
Revenue:
-
Net Income/Loss:
$-75.27M
P/E Ratio:
-24.15
EPS:
-1.6963
Net Cash Flow:
$-66.67M
1W Performance:
+3.49%
1M Performance:
+1.19%
6M Performance:
+16.79%
1Y Performance:
+220.33%
1-Day Range:
Value
$40.42
$43.73
1-Week Range:
Value
$36.50
$43.73
52-Week Range:
Value
$11.77
$46.46

Sionna Therapeutics Inc Stock (SION) Company Profile

Name
Name
Sionna Therapeutics Inc
Name
Phone
617-819-2020
Name
Address
21 HICKORY DRIVE, SUITE 500, WALTHAM
Name
Employee
59
Name
Twitter
Name
Next Earnings Date
2026-05-11
Name
Latest SEC Filings
Name
SION's Discussions on Twitter

Compare SION vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SION icon
SION
Sionna Therapeutics Inc
40.97 1.83B 0 -75.27M -66.67M -1.6963
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
424.36 109.34B 12.32B 4.34B 3.19B 16.86
REGN icon
REGN
Regeneron Pharmaceuticals Inc
702.27 74.35B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
794.70 50.44B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
301.11 39.78B 3.71B 313.75M 465.38M 2.2571
ONC icon
ONC
Beone Medicines Ltd Adr
297.49 33.02B 5.36B 287.73M 924.18M 2.5229

Sionna Therapeutics Inc Stock (SION) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-24-26 Initiated Citizens Mkt Outperform
Dec-01-25 Downgrade RBC Capital Mkts Sector Perform → Underperform
Nov-19-25 Initiated BTIG Research Buy
Sep-03-25 Initiated RBC Capital Mkts Sector Perform
Sep-03-25 Initiated Raymond James Strong Buy
Mar-04-25 Initiated Guggenheim Buy
Mar-04-25 Initiated Stifel Buy
Mar-04-25 Initiated TD Cowen Buy
View All

Sionna Therapeutics Inc Stock (SION) Latest News

pulisher
10:11 AM

A Look At Sionna Therapeutics (SION) Valuation After Its Strong 1 Year Return And Premium P/B Ratio - Yahoo Finance

10:11 AM
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02:23 AM

Wedbush initiates Sionna Therapeutics stock with Outperform rating By Investing.com - Investing.com South Africa

02:23 AM
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May 01, 2026

Sionna Insider Sells $2.5 Million in Stock Amid 215% Surge, but Here's What Investors Should Watch - AOL.com

May 01, 2026
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May 01, 2026

Sionna Therapeutics, Inc. $SION Shares Acquired by Jennison Associates LLC - MarketBeat

May 01, 2026
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Apr 28, 2026

Trial of SION-719 as Trikafta add-on therapy in CF is fully enrolled - Cystic Fibrosis News Today

Apr 28, 2026
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Apr 28, 2026

JonesTrading Forecasts Strong Price Appreciation for Sionna Therapeutics (NASDAQ:SION) Stock - MarketBeat

Apr 28, 2026
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Apr 28, 2026

Jones Trading raises Sionna Therapeutics price target on trial progress By Investing.com - Investing.com Canada

Apr 28, 2026
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Apr 28, 2026

EDGAR Filing Documents for 0001628280-26-027501 - SEC.gov

Apr 28, 2026
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Apr 27, 2026

Sionna Therapeutics (NASDAQ: SION) details 2026 virtual meeting, board elections - Stock Titan

Apr 27, 2026
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Apr 27, 2026

Sionna Insider Sells $2.5 Million in Stock Amid 215% Surge, but Here's What Investors Should Watch - The Motley Fool

Apr 27, 2026
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Apr 27, 2026

Sionna Therapeutics Completes Phase 2a Enrollment for SION-719 in Cystic Fibrosis - marketscreener.com

Apr 27, 2026
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Apr 27, 2026

Sionna completes enrollment in cystic fibrosis drug trial By Investing.com - Investing.com Canada

Apr 27, 2026
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Apr 27, 2026

Sionna Therapeutics Completes Enrollment in PreciSION CF Phase 2a Trial for SION-719 in Cystic Fibrosis - Quiver Quantitative

Apr 27, 2026
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Apr 27, 2026

Sionna Therapeutics Completes Enrollment in PreciSION CF Phase 2a Trial Evaluating NBD1 Stabilizer, SION-719, Added to Standard of Care in Participants with Cystic Fibrosis - ChartMill

Apr 27, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Q1 2025 earnings summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) 44th Annual J.P. Morgan Healthcare Conference Summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Cantor Global Healthcare Conference 2025 Summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Leerink Global Healthcare Conference 2026 Summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Q4 2025 earnings summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Q2 2025 earnings summary - Quartr

Apr 26, 2026
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Apr 26, 2026

Sionna Therapeutics (SION) Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary - Quartr

Apr 26, 2026
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Apr 23, 2026

Sionna Therapeutics (NASDAQ:SION) Stock Price Down 11.3%What's Next? - MarketBeat

Apr 23, 2026
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Apr 22, 2026

Sionna Therapeutics Insider Sold Shares Worth $2,472,343, According to a Recent SEC Filing - marketscreener.com

Apr 22, 2026
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Apr 22, 2026

OrbiMed Advisors sells $2.47m in Sionna Therapeutics stock By Investing.com - Investing.com Australia

Apr 22, 2026
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Apr 21, 2026

Sionna Therapeutics (NASDAQ:SION) Director Peter Thompson Sells 52,397 Shares - MarketBeat

Apr 21, 2026
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Apr 21, 2026

Sionna Therapeutics (NASDAQ:SION) Director Sells $2,341,097.96 in Stock - MarketBeat

Apr 21, 2026
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Apr 21, 2026

Insider Selling: Sionna Therapeutics (NASDAQ:SION) Director Sells 2,948 Shares of Stock - MarketBeat

Apr 21, 2026
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Apr 21, 2026

Sionna Therapeutics director Peter A. Thompson sells $2.47m in stock - Investing.com

Apr 21, 2026
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Apr 21, 2026

OrbiMed Advisors sells $2.47m in Sionna Therapeutics stock - Investing.com

Apr 21, 2026
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Apr 21, 2026

Sionna Therapeutics director Peter A. Thompson sells $2.47m in stock By Investing.com - Investing.com India

Apr 21, 2026
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Apr 21, 2026

OrbiMed fund tied to Sionna (NASDAQ: SION) director trims 55K shares - Stock Titan

Apr 21, 2026
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Apr 21, 2026

OrbiMed-backed Sionna (NASDAQ: SION) sees fund share sale - Stock Titan

Apr 21, 2026
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Apr 21, 2026

Why Sionna Therapeutics Stock Is Sinking Now - TipRanks

Apr 21, 2026
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Apr 20, 2026

OrbiMed (SION) cuts Sionna stake to 6.6% after April share sales - Stock Titan

Apr 20, 2026
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Apr 18, 2026

Is Sionna Therapeutics (SION) stock expensive relative to growth (-3.76%) 2026-04-18Weak Sell Rating - Cổng thông tin điện tử tỉnh Tây Ninh

Apr 18, 2026
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Apr 17, 2026

OrbiMed Advisors sells Sionna Therapeutics (SION) stock worth $22.9m By Investing.com - Investing.com UK

Apr 17, 2026
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Apr 16, 2026

Peter Thompson Sells 235,863 Shares of Sionna Therapeutics (NASDAQ:SION) Stock - MarketBeat

Apr 16, 2026
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Apr 16, 2026

Orbimed Advisors Llc Sells 235,863 Shares of Sionna Therapeutics (NASDAQ:SION) Stock - MarketBeat

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics (NASDAQ:SION) Director Peter Thompson Sells 47,814 Shares - MarketBeat

Apr 16, 2026
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Apr 16, 2026

Insider Selling: Sionna Therapeutics (NASDAQ:SION) Director Sells 226,906 Shares of Stock - MarketBeat

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics (SION) director Thompson sells $22.9 million in stock By Investing.com - Investing.com Canada

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics (SION) director Thompson sells $22.9 million in stock - Investing.com

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics(SION.US) Director Sells US$22.95 Million in Common Stock - Moomoo

Apr 16, 2026
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Apr 16, 2026

OrbiMed Advisors sells Sionna Therapeutics (SION) stock worth $22.9m - Investing.com

Apr 16, 2026
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Apr 16, 2026

OrbiMed fund linked to Sionna Therapeutics (SION) director sells 510K shares - Stock Titan

Apr 16, 2026
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Apr 16, 2026

OrbiMed entities sell Sionna Therapeutics (SION) stock under 10b5-1 plan - Stock Titan

Apr 16, 2026
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Apr 16, 2026

Operating cash flow per share of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics stock hits all-time high at 45.17 USD By Investing.com - Investing.com Australia

Apr 16, 2026
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Apr 16, 2026

Why Sionna Therapeutics Stock Is Sliding After a Surge - TipRanks

Apr 16, 2026
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Apr 16, 2026

Sionna Therapeutics, Inc. (NASDAQ:SION) Receives Consensus Rating of "Moderate Buy" from Brokerages - MarketBeat

Apr 16, 2026

Sionna Therapeutics Inc Stock (SION) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$28.32
price down icon 0.14%
$50.44
price up icon 0.48%
$95.50
price down icon 3.88%
$139.44
price down icon 0.41%
$147.21
price down icon 0.47%
ONC ONC
$297.49
price up icon 0.12%
Cap:     |  Volume (24h):