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Sionna Therapeutics Inc stock is traded at $45.70, with a volume of 654.83K. It is up +3.72% in the last 24 hours and up +11.22% over the past month. Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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Previous Close:
$44.06
Open:
$44.31
24h Volume:
654.83K
Relative Volume:
1.42
Market Cap:
$2.06B
Revenue:
-
Net Income/Loss:
$-85.57M
P/E Ratio:
-23.84
EPS:
-1.9166
Net Cash Flow:
$-72.14M
1W Performance:
-7.51%
1M Performance:
+11.22%
6M Performance:
+7.83%
1Y Performance:
+138.77%
1-Day Range:
Value
$43.41
$46.40
1-Week Range:
Value
$43.41
$51.56
52-Week Range:
Value
$16.38
$51.56

Sionna Therapeutics Inc Stock (SION) Company Profile

Name
Name
Sionna Therapeutics Inc
Name
Phone
617-819-2020
Name
Address
21 HICKORY DRIVE, SUITE 500, WALTHAM
Name
Employee
59
Name
Twitter
Name
Next Earnings Date
2026-08-10
Name
Latest SEC Filings
Name
SION's Discussions on Twitter

Compare SION vs VRTX, REGN, ARGX, RVMD, ALNY

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SION icon
SION
Sionna Therapeutics Inc
45.70 2.06B 0 -85.57M -72.14M -1.9166
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
477.36 121.16B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
656.01 68.78B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
918.22 57.44B 4.16B 1.29B 734.26M 19.58
RVMD icon
RVMD
Revolution Medicines Inc
189.23 40.23B 742.00K -1.37B -1.07B -7.0731
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
271.77 36.28B 4.29B 577.22M 641.34M 4.2086

Sionna Therapeutics Inc Stock (SION) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-24-26 Initiated Citizens Mkt Outperform
Dec-01-25 Downgrade RBC Capital Mkts Sector Perform → Underperform
Nov-19-25 Initiated BTIG Research Buy
Sep-03-25 Initiated RBC Capital Mkts Sector Perform
Sep-03-25 Initiated Raymond James Strong Buy
Mar-04-25 Initiated Guggenheim Buy
Mar-04-25 Initiated Stifel Buy
Mar-04-25 Initiated TD Cowen Buy
View All

Sionna Therapeutics Inc Stock (SION) Latest News

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Jul 23, 2026

Sionna Therapeutics Slides as Lofty Valuation Deflates - TipRanks

Jul 23, 2026
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Jul 20, 2026

Sionna Therapeutics Inc. (SION) Stock Price | Live Quotes & Charts | NASDAQ - timothysykes.com

Jul 20, 2026
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Jul 18, 2026

SION Jumps As Sionna Therapeutics Stock Extends Breakout - StocksToTrade

Jul 18, 2026
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Jul 18, 2026

SION Jumps As Sionna Therapeutics Draws Trader Attention - StocksToTrade

Jul 18, 2026
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Jul 17, 2026

Sionna Therapeutics (SION) Sees 9.2% Surge in Stock Price - GuruFocus

Jul 17, 2026
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Jul 17, 2026

Sionna Therapeutics stock hits all-time high at 48.66 USD - Investing.com

Jul 17, 2026
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Jul 17, 2026

Sionna Therapeutics stock hits all-time high at 48.66 USD By Investing.com - Investing.com South Africa

Jul 17, 2026
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Jul 17, 2026

Sionna Therapeutics Surges As CF Trial Data Loom - TipRanks

Jul 17, 2026
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Jul 15, 2026

Orbimed Advisors LLC Reduces Stake in Sionna Therapeutics Inc - GuruFocus

Jul 15, 2026
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Jul 14, 2026

Sionna Therapeutics, Inc. Common Stock (SION) Stock Price Today: $42.59 - Gotrade

Jul 14, 2026
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Jul 11, 2026

Wedbush initiates coverage of Sionna Therapeutics (SION) with outperform recommendation - MSN

Jul 11, 2026
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Jul 10, 2026

Sionna Therapeutics(SION.US) Director Sells US$3.85 Million in Common Stock - Moomoo

Jul 10, 2026
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Jul 09, 2026

Form 4 Sionna Therapeutics Inc For: 9 July By Investing.com - Investing.com Nigeria

Jul 09, 2026
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Jul 09, 2026

OrbiMed Advisors, Sionna director, sells $3.85 million in stock - Investing.com UK

Jul 09, 2026
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Jul 09, 2026

Sionna Therapeutics director Peter Thompson sells $3.85m in stock - Investing.com

Jul 09, 2026
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Jul 09, 2026

Sionna Therapeutics Insider Sold Shares Worth $3,854,281, According to a Recent SEC Filing - Moomoo

Jul 09, 2026
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Jul 09, 2026

Sionna Therapeutics director Peter Thompson sells $3.85m in stock By Investing.com - Investing.com Canada

Jul 09, 2026
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Jul 07, 2026

Sionna Therapeutics CLO Jennifer Fitzpatrick sells $446k in stock - Investing.com

Jul 07, 2026
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Jul 07, 2026

Sionna Therapeutics CLO Jennifer Fitzpatrick sells $446k in stock By Investing.com - Investing.com Nigeria

Jul 07, 2026
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Jul 07, 2026

Form 4 Sionna Therapeutics Inc For: 7 July By Investing.com - Investing.com Nigeria

Jul 07, 2026
pulisher
Jul 06, 2026

Sionna Therapeutics (SION) Jefferies Global Healthcare Conference 2026 Summary - Quartr

Jul 06, 2026
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Jul 04, 2026

Is Sionna Therapeutics (SION) Undervalued Or Already Priced In As Index Changes Draw Focus? - simplywall.st

Jul 04, 2026
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Jul 03, 2026

ETFs Investing in Sionna Therapeutics, Inc. Stocks - TradingView

Jul 03, 2026
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Jul 03, 2026

SIONSionna Therapeutics Inc Options - Finviz

Jul 03, 2026
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Jul 02, 2026

Form 4 Sionna Therapeutics Inc For: 2 July By Investing.com - Investing.com Nigeria

Jul 02, 2026
pulisher
Jul 02, 2026

Sionna Therapeutics director Thompson sells $5.27m in stock By Investing.com - Investing.com South Africa

Jul 02, 2026
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Jul 02, 2026

Sionna Therapeutics director Thompson sells $5.27m in stock - Investing.com

Jul 02, 2026
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Jul 02, 2026

Sionna Therapeutics Inc. (SION) Q1 2026 Earnings: Clinical-Stage Biotech Misses EPS Estimates Amid No RevenueROE Trend Analysis - dars.gov.et

Jul 02, 2026
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Jul 01, 2026

Enterprise value to EBITDA forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Enterprise value to EBIT forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Enterprise value to revenue forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Price to earnings forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Price to sales forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jun 30, 2026

Sionna Therapeutics: NBD1 Stabilization Could Redefine Cystic Fibrosis Treatment (SION) - Seeking Alpha

Jun 30, 2026
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Jun 29, 2026

Sionna Therapeutics, Inc.(NasdaqGM: SION) dropped from Russell 3000E Index - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Sionna Therapeutics, Inc.(NasdaqGM: SION) dropped from Russell Microcap Index - marketscreener.com

Jun 29, 2026
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Jun 28, 2026

Sionna Therapeutics, Inc.(NasdaqGM:SION) dropped from Russell Microcap Growth Benchmark Index - marketscreener.com

Jun 28, 2026
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Jun 26, 2026

Analysts Offer Insights on Healthcare Companies: Sionna Therapeutics, Inc. (SION) and Janux Therapeutics Inc (JANX) - The Globe and Mail

Jun 26, 2026
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Jun 25, 2026

Sionna Therapeutics, Inc. Actuals & Estimates (NASDAQ:SION) - TradingView

Jun 25, 2026
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Jun 25, 2026

SION Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 25, 2026

JonesTrading Maintains Sionna Therapeutics(SION.US) With Buy Rating, Maintains Target Price $63 - Moomoo

Jun 25, 2026
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Jun 24, 2026

Analysts Offer Insights on Healthcare Companies: AbbVie (ABBV), Sionna Therapeutics, Inc. (SION) and Crescent Biopharma (CBIO) - The Globe and Mail

Jun 24, 2026
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Jun 23, 2026

Citizens reiterates Sionna Therapeutics stock rating ahead of summer data By Investing.com - Investing.com Nigeria

Jun 23, 2026
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Jun 23, 2026

Guggenheim Maintains Sionna Therapeutics(SION.US) With Buy Rating, Maintains Target Price $50 - Moomoo

Jun 23, 2026
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Jun 22, 2026

Sionna Therapeutics: Buy Rating Reiterated on NBD1-Focused CF Strategy; $60 Price Target Maintained - TipRanks

Jun 22, 2026
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Jun 19, 2026

Sionna Stockholders Reelect Directors, Ratify Deloitte as Auditor - The Globe and Mail

Jun 19, 2026
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Jun 18, 2026

LifeSci Capital Maintains Sionna Therapeutics(SION.US) With Buy Rating, Maintains Target Price $60 - Moomoo

Jun 18, 2026
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Jun 17, 2026

Sionna Therapeutics Surges 5.7%: Testing Key Resistance at $38.57Technical Analysis Picks - dars.gov.et

Jun 17, 2026

Sionna Therapeutics Inc Stock (SION) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Sionna Therapeutics Inc Stock (SION) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
ORBIMED ADVISORS LLC
Director
Jul 07 '26
Sale
44.86
85,918
3,854,281
2,469,959
Fitzpatrick Jennifer
Chief Legal Officer
Jul 06 '26
Option Exercise
6.11
10,250
62,628
10,250
Fitzpatrick Jennifer
Chief Legal Officer
Jul 06 '26
Sale
43.60
10,250
446,862
0
$106.92
price down icon 0.46%
$117.67
price up icon 0.84%
$35.01
price down icon 0.26%
$58.83
price down icon 0.32%
ONC ONC
$325.90
price down icon 0.27%
$271.77
price up icon 1.13%
Cap:     |  Volume (24h):