72.40
price up icon2.19%   1.55
after-market After Hours: 74.40 2.00 +2.76%
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Spruce Biosciences Inc stock is traded at $72.40, with a volume of 29,946. It is up +2.19% in the last 24 hours and down -10.14% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$70.85
Open:
$71.17
24h Volume:
29,946
Relative Volume:
0.35
Market Cap:
$77.49M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-77.02
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
-6.64%
1M Performance:
-10.14%
6M Performance:
-86.68%
1Y Performance:
-90.34%
1-Day Range:
Value
$71.00
$74.40
1-Week Range:
Value
$69.02
$83.49
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
72.40 75.84M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
477.92 116.41B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
785.51 81.05B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
811.45 50.76B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
328.16 43.76B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
353.92 38.40B 4.98B 69.60M 525.67M 0.5198

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-23-25 Initiated Oppenheimer Outperform
Dec-03-25 Upgrade Leerink Partners Market Perform → Outperform
Oct-28-25 Upgrade Citizens JMP Mkt Perform → Mkt Outperform
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

pulisher
Feb 06, 2026

Spruce Biosciences: TA-ERT’s Promising Long-Term Data and Priority Review Voucher Upside Underpin Reiterated Buy and $220 Target - TipRanks

Feb 06, 2026
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Feb 05, 2026

Experimental enzyme therapy stabilizes skills for 6 years in fatal disorder - stocktitan.net

Feb 05, 2026
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Feb 04, 2026

Spruce Biosciences Adds Regulatory and Clinical Development Expertise to Leadership Team - BioSpace

Feb 04, 2026
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Feb 03, 2026

Spruce Biosciences Makes Two SVP Appointments - Contract Pharma

Feb 03, 2026
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Feb 03, 2026

Spruce Biosciences (NASDAQ:SPRB) Shares Up 0.6%Time to Buy? - MarketBeat

Feb 03, 2026
pulisher
Jan 29, 2026

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium™ - BioSpace

Jan 29, 2026
pulisher
Jan 28, 2026

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium - Investing News Network

Jan 28, 2026
pulisher
Jan 21, 2026

Harbour BioMed Exercises Warrant to Acquire 3.8% of Spruce Biosciences Inc. - intellectia.ai

Jan 21, 2026
pulisher
Jan 21, 2026

Big-Pharma Partner Harbour BioMed Boosts Stake In Spruce Biosciences - Benzinga

Jan 21, 2026
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Jan 20, 2026

Harbour BioMed Acquires Stake in U.S. Partner Spruce Biosciences, Signaling Strategic Shift in Chinese Biotech - IndexBox

Jan 20, 2026
pulisher
Jan 20, 2026

Harbour BioMed Acquires 3.8% of Spruce Biosciences, Enhancing Strategic Partnership - intellectia.ai

Jan 20, 2026
pulisher
Jan 19, 2026

Harbour BioMed Expands Stake in Spruce Biosciences (SPRB) - GuruFocus

Jan 19, 2026
pulisher
Jan 19, 2026

Harbour BioMed Exercises Agreement to Buy Spruce Biosciences Common Stock - Contract Pharma

Jan 19, 2026
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Jan 18, 2026

Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences (SPRB) - Intellectia AI

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences - Intellectia AI

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deep - GuruFocus

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed Exercises Warrant To Acquire Stake In Spruce Biosciences - Nasdaq

Jan 18, 2026
pulisher
Jan 18, 2026

HBM Holdings Deepens Ties With Spruce Biosciences via Warrant Exercise - TipRanks

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed buys into Spruce to back new hormone disorder drug - Stock Titan

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration - Barchart.com

Jan 18, 2026
pulisher
Jan 18, 2026

Harbour BioMed takes stake in Spruce Biosciences - MSN

Jan 18, 2026
pulisher
Jan 18, 2026

HBM Lifts Spruce Biosciences Stake to About 3.8% After Warrant Exercise - marketscreener.com

Jan 18, 2026
pulisher
Jan 14, 2026

Spruce Biosciences (SPRB) Price Target Increased by 10.02% to 235.11 - Nasdaq

Jan 14, 2026
pulisher
Jan 11, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) Receives Average Rating of "Moderate Buy" from Analysts - MarketBeat

Jan 11, 2026
pulisher
Jan 08, 2026

Spruce Biosciences Secures Up to $50 Million in Growth Capital from Avenue Capital - BioSpace

Jan 08, 2026
pulisher
Jan 08, 2026

Spruce Biosciences secures up to $50 million in growth capital from Avenue Capital - marketscreener.com

Jan 08, 2026
pulisher
Jan 08, 2026

Spruce Biosciences Signs Multiple Financing Agreements - TradingView — Track All Markets

Jan 08, 2026
pulisher
Jan 01, 2026

Spruce Biosciences (SPRB) price target increased by 55.76% to 213.69 - MSN

Jan 01, 2026
pulisher
Dec 29, 2025

MSN Money - MSN

Dec 29, 2025
pulisher
Dec 28, 2025

Spruce Biosciences assumed with a buy at HC Wainwright - MSN

Dec 28, 2025
pulisher
Dec 27, 2025

Spruce Biosciences (NASDAQ:SPRB) Lowered to Sell Rating by Wall Street Zen - MarketBeat

Dec 27, 2025
pulisher
Dec 24, 2025

Equities Analysts Offer Predictions for SPRB FY2025 Earnings - MarketBeat

Dec 24, 2025
pulisher
Dec 24, 2025

Spruce Biosciences initiated with an Outperform at Oppenheimer - Yahoo Finance

Dec 24, 2025
pulisher
Dec 23, 2025

Oppenheimer Initiates Coverage on SPRB with "Outperform" Rating - GuruFocus

Dec 23, 2025
pulisher
Dec 23, 2025

Coty downgraded, Spruce Biosciences initiated: Wall Street's top analyst calls - Yahoo Finance

Dec 23, 2025
pulisher
Dec 23, 2025

Oppenheimer starts Spruce Biosciences with "outperform" rating on rare disease strength - TradingView — Track All Markets

Dec 23, 2025
pulisher
Dec 23, 2025

Oppenheimer initiates coverage on Spruce Biosciences stock with Outperform rating - Investing.com Australia

Dec 23, 2025
pulisher
Dec 23, 2025

Oppenheimer Initiates Coverage of Spruce Biosciences (SPRB) with Outperform Recommendation - Nasdaq

Dec 23, 2025
pulisher
Dec 23, 2025

Revenue per share of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView — Track All Markets

Dec 23, 2025
pulisher
Dec 22, 2025

Spruce Biosciences stock rating resumed at Buy by H.C. Wainwright - Investing.com Nigeria

Dec 22, 2025
pulisher
Dec 22, 2025

HC Wainwright Reaffirms Buy Rating for Spruce Biosciences (NASDAQ:SPRB) - MarketBeat

Dec 22, 2025
pulisher
Dec 22, 2025

SPRB Stock: HC Wainwright & Co. Initiates Coverage with Buy Rati - GuruFocus

Dec 22, 2025
pulisher
Dec 21, 2025

Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to S&P TMI Index - marketscreener.com

Dec 21, 2025
pulisher
Dec 20, 2025

With Spruce Biosciences Stock Sliding, Have You Assessed The Risk? - Trefis

Dec 20, 2025
pulisher
Dec 17, 2025

[Form 4] SPRUCE BIOSCIENCES, INC. Insider Trading Activity - Stock Titan

Dec 17, 2025
pulisher
Dec 17, 2025

Spruce Biosciences CEO reports RSU vesting and option repricing | SPRB SEC FilingForm 4 - Stock Titan

Dec 17, 2025
pulisher
Dec 17, 2025

Spruce Biosciences, Inc. (NASDAQ:SPRB) Given Average Recommendation of "Moderate Buy" by Analysts - MarketBeat

Dec 17, 2025
pulisher
Dec 17, 2025

Spruce Biosciences Appoints Keli Walbert as Director - The Globe and Mail

Dec 17, 2025

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$30.90
price down icon 0.23%
$44.65
price up icon 1.25%
$108.39
price up icon 5.48%
$106.62
price up icon 1.02%
$149.86
price down icon 0.77%
biotechnology ONC
$353.92
price up icon 1.99%
Cap:     |  Volume (24h):