90.61
price up icon0.50%   0.45
after-market After Hours: 89.38 -1.23 -1.36%
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Spruce Biosciences Inc stock is traded at $90.61, with a volume of 45,765. It is up +0.50% in the last 24 hours and down -13.66% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$90.16
Open:
$89.7
24h Volume:
45,765
Relative Volume:
0.09
Market Cap:
$96.99M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-96.39
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
-17.63%
1M Performance:
-13.66%
6M Performance:
-86.69%
1Y Performance:
-90.34%
1-Day Range:
Value
$83.00
$92.40
1-Week Range:
Value
$74.01
$111.00
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
90.61 96.50M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
457.26 117.50B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
722.83 76.06B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
464.56 62.53B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ARGX
Argen X Se Adr
916.31 56.75B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
INSM
Insmed Inc
205.04 44.10B 447.02M -1.18B -906.14M -6.1812

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Oct-28-25 Upgrade Citizens JMP Mkt Perform → Mkt Outperform
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

pulisher
Dec 03, 2025

Leerink Partners Upgrades Spruce Biosciences (SPRB) - Nasdaq

Dec 03, 2025
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Dec 03, 2025

Spruce Biosciences Shares Rise After Upgrade From Leerink - MarketScreener

Dec 03, 2025
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Dec 03, 2025

SPRB: Leerink Partners Upgrades to Outperform with $160 Target | - GuruFocus

Dec 03, 2025
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Dec 03, 2025

Leerink Partners upgrades Spruce Biosciences stock to Outperform By Investing.com - Investing.com Canada

Dec 03, 2025
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Dec 03, 2025

Leerink Partners upgrades Spruce Biosciences stock to Outperform - Investing.com

Dec 03, 2025
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Dec 01, 2025

After-Hours Spotlight: Jasper, NRx, Unicycive, Spruce, Evaxion, Solana, Protara Gain Post-Close - Nasdaq

Dec 01, 2025
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Nov 17, 2025

Spruce Biosciences (SPRB) Price Target Increased by 2,045.14% to 137.19 - Nasdaq

Nov 17, 2025
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Nov 11, 2025

Citizens raises Spruce Biosciences stock price target to $259 on MPS IIIB therapy - Investing.com Australia

Nov 11, 2025
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Nov 11, 2025

Citizens raises Spruce Biosciences stock price target to $259 on MPS IIIB therapy By Investing.com - Investing.com South Africa

Nov 11, 2025
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Nov 11, 2025

Citizens Maintains Spruce Biosciences (SPRB) Market Outperform Recommendation - Nasdaq

Nov 11, 2025
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Nov 11, 2025

SPRB: Citizens Raises Price Target for Spruce Biosciences | SPRB Stock News - GuruFocus

Nov 11, 2025
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Nov 10, 2025

Spruce Biosciences Reports Q3 2025 Financial Results - TipRanks

Nov 10, 2025
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Nov 10, 2025

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates - BioSpace

Nov 10, 2025
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Nov 10, 2025

SPRB Announces Key Financing Milestones and Regulatory Achieveme - GuruFocus

Nov 10, 2025
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Nov 10, 2025

Spruce Biosciences Q3 net loss narrows - MarketScreener

Nov 10, 2025
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Nov 07, 2025

Spruce Biosciences Inc expected to post a loss of $13.93 a shareEarnings Preview - TradingView

Nov 07, 2025
pulisher
Nov 04, 2025

Spruce Biosciences (SPRB) Expected to Announce Earnings on Monday - MarketBeat

Nov 04, 2025
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Nov 03, 2025

One new option listing and two option delistings on September 5th - MSN

Nov 03, 2025
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Oct 31, 2025

Small Cap Stocks To Follow TodayOctober 6th - MarketBeat

Oct 31, 2025
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Oct 31, 2025

Biotech And Tech Stocks Rally On Breakthrough News And Partnerships - Finimize

Oct 31, 2025
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Oct 30, 2025

Spruce Biosciences (SPRB) Price Target Decreased by 37.30% to 6.40 - MSN

Oct 30, 2025
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Oct 29, 2025

[S-3] SPRUCE BIOSCIENCES, INC. Shelf Registration Statement | SPRB SEC FilingForm S-3 - Stock Titan

Oct 29, 2025
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Oct 29, 2025

Spruce Biosciences, Inc. (NASDAQ:SPRB) Given Average Rating of "Hold" by Brokerages - MarketBeat

Oct 29, 2025
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Oct 29, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded to "Outperform" at Citizens Jmp - MarketBeat

Oct 29, 2025
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Oct 28, 2025

Spruce Biosciences Stock Rallied 1184%Have You Assessed the Risk - Trefis

Oct 28, 2025
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Oct 28, 2025

JMP Securities Upgrades Spruce Biosciences (SPRB) - Nasdaq

Oct 28, 2025
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Oct 28, 2025

Cash per share of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView

Oct 28, 2025
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Oct 28, 2025

SPRB: JMP Securities Upgrades Spruce Biosciences to Market Outpe - GuruFocus

Oct 28, 2025
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Oct 28, 2025

Spruce Biosciences Raised to Market Outperform From Market Perform by JMP Securities - 富途牛牛

Oct 28, 2025
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Oct 28, 2025

Spruce Biosciences stock upgraded by Citizens on promising MPS IIIB therapy - Investing.com Nigeria

Oct 28, 2025
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Oct 27, 2025

Spruce Biosciences Stock Dropped 16%Have You Assessed the Risk - Trefis

Oct 27, 2025
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Oct 26, 2025

Spruce Biosciences (NASDAQ:SPRB) Stock Rating Lowered by Zacks Research - MarketBeat

Oct 26, 2025
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Oct 24, 2025

What is Leerink Partnrs' Forecast for SPRB FY2025 Earnings? - MarketBeat

Oct 24, 2025
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Oct 24, 2025

Levi & Korsinsky Reminds Spruce Biosciences Investors of the Ongoing Investigation into Potential Violations of Securities LawsSPRB - ACCESS Newswire

Oct 24, 2025
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Oct 24, 2025

Spruce Biosciences Announces $50 Million Private Placement Financing - Global Legal Chronicle

Oct 24, 2025
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Oct 22, 2025

Spruce Biosciences CFO vests 2,053 RSUs; owns 6,066 shares - Stock Titan

Oct 22, 2025
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Oct 22, 2025

SPRB insider filing: CEO nets 3,245 shares after RSU vest - Stock Titan

Oct 22, 2025
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Oct 22, 2025

The science behind the therapy that catapulted a biopharma’s stock 1,400% and counting - Healthcare Brew

Oct 22, 2025
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Oct 22, 2025

Leerink Partners Maintains Spruce Biosciences (SPRB) Market Perform Recommendation - Nasdaq

Oct 22, 2025
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Oct 21, 2025

Spruce Biosciences (SPRB): Analyst Raises Price Target Significa - GuruFocus

Oct 21, 2025
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Oct 21, 2025

Spruce Biosciences stock price target raised to $160 from $10 at Leerink - Investing.com Philippines

Oct 21, 2025
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Oct 20, 2025

Spruce Biosciences (SPRB) Skyrockets 1,300% on FDA Breakthrough – Inside the Stock Surge, Pipeline & Outlook (Oct 2025) - ts2.tech

Oct 20, 2025
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Oct 20, 2025

Mintz Advises the Placement Agents in Spruce Biosciences, Inc.’s $50 Million Private Placement - Mintz

Oct 20, 2025
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Oct 19, 2025

Spruce Biosciences (SPRB) Skyrockets 1,300% on FDA Breakthrough News – Experts Weigh In - ts2.tech

Oct 19, 2025
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Oct 19, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded at Zacks Research - Defense World

Oct 19, 2025
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Oct 18, 2025

SPRUCE BIOSCIENCES, INC. trading resumes - MSN

Oct 18, 2025
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Oct 18, 2025

Spruce Biosciences (NASDAQ:SPRB) Rating Increased to Strong-Buy at Zacks Research - MarketBeat

Oct 18, 2025
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Oct 17, 2025

SPRB director steps down; company notes no disagreement - Stock Titan

Oct 17, 2025
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Oct 17, 2025

Spruce Biosciences, Inc. Announces Resignation of Bali Muralidhar as Member of Board of Directors and as Member of the Compensation Committee of the Board, Effective October 15, 2025 - MarketScreener

Oct 17, 2025
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Oct 16, 2025

Spruce Biosciences Stock More Than Quadruples After Breakthrough Therapy Designation To Therapy For Rare And Fatal Genetic Disease - MSN

Oct 16, 2025
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Oct 16, 2025

Head to Head Contrast: PyroGenesis Canada (NASDAQ:PYRGF) vs. Spruce Biosciences (NASDAQ:SPRB) - Defense World

Oct 16, 2025

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$39.16
price down icon 1.10%
$100.48
price down icon 1.00%
$32.03
price up icon 1.10%
$95.99
price down icon 0.77%
biotechnology ONC
$331.27
price down icon 1.95%
$205.04
price down icon 0.84%
Cap:     |  Volume (24h):