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Spruce Biosciences Inc stock is traded at $83.40, with a volume of 8,401. It is up +0.51% in the last 24 hours and down -23.25% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$84.00
Open:
$83.4
24h Volume:
8,401
Relative Volume:
0.02
Market Cap:
$90.37M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-88.72
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
+7.23%
1M Performance:
-23.25%
6M Performance:
-86.69%
1Y Performance:
-90.34%
1-Day Range:
Value
$82.88
$85.31
1-Week Range:
Value
$77.48
$87.11
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
84.43 89.91M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
461.75 117.47B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
778.30 82.37B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
400.37 52.94B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ARGX
Argen X Se Adr
848.83 52.33B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
INSM
Insmed Inc
178.20 37.84B 447.02M -1.18B -906.14M -6.1812

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-23-25 Initiated Oppenheimer Outperform
Dec-03-25 Upgrade Leerink Partners Market Perform → Outperform
Oct-28-25 Upgrade Citizens JMP Mkt Perform → Mkt Outperform
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

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Dec 24, 2025

Equities Analysts Offer Predictions for SPRB FY2025 Earnings - MarketBeat

Dec 24, 2025
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Dec 24, 2025

Spruce Biosciences initiated with an Outperform at Oppenheimer - Yahoo Finance

Dec 24, 2025
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Dec 23, 2025

Oppenheimer Initiates Coverage on SPRB with "Outperform" Rating - GuruFocus

Dec 23, 2025
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Dec 23, 2025

Coty downgraded, Spruce Biosciences initiated: Wall Street's top analyst calls - Yahoo Finance

Dec 23, 2025
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Dec 23, 2025

Oppenheimer starts Spruce Biosciences with "outperform" rating on rare disease strength - TradingView — Track All Markets

Dec 23, 2025
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Dec 23, 2025

Oppenheimer initiates coverage on Spruce Biosciences stock with Outperform rating - Investing.com Nigeria

Dec 23, 2025
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Dec 23, 2025

Oppenheimer Initiates Coverage of Spruce Biosciences (SPRB) with Outperform Recommendation - Nasdaq

Dec 23, 2025
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Dec 22, 2025

Spruce Biosciences stock rating resumed at Buy by H.C. Wainwright - Investing.com Nigeria

Dec 22, 2025
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Dec 22, 2025

HC Wainwright Reaffirms Buy Rating for Spruce Biosciences (NASDAQ:SPRB) - MarketBeat

Dec 22, 2025
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Dec 22, 2025

SPRB Stock: HC Wainwright & Co. Initiates Coverage with Buy Rati - GuruFocus

Dec 22, 2025
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Dec 17, 2025

[Form 4] SPRUCE BIOSCIENCES, INC. Insider Trading Activity - Stock Titan

Dec 17, 2025
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Dec 17, 2025

Spruce Biosciences CEO reports RSU vesting and option repricing | SPRB SEC FilingForm 4 - Stock Titan

Dec 17, 2025
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Dec 17, 2025

Spruce Biosciences, Inc. (NASDAQ:SPRB) Given Average Recommendation of "Moderate Buy" by Analysts - MarketBeat

Dec 17, 2025
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Dec 17, 2025

Spruce Biosciences Appoints Keli Walbert as Director - The Globe and Mail

Dec 17, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) adjusts director option exercise prices to $104.13 - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (NASDAQ: SPRB) reprices stock options after reverse split - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) details one-time executive stock option repricing - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) discloses CEO stock option repricing to $104.13 - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (NASDAQ: SPRB) details one-time director option repricing - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) details 800 stock options repriced for director - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) director receives 3,400 options at $88.41 - Stock Titan

Dec 15, 2025
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Dec 15, 2025

[Form 3] SPRUCE BIOSCIENCES, INC. Initial Statement of Beneficial Ownership - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directo - PharmiWeb.com

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences appoints Keli Walbert to board of directors By Investing.com - Investing.com Australia

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences appoints Keli Walbert to board of directors - marketscreener.com

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences Appoints Keli Walbert To Board Of Directors - TradingView — Track All Markets

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (NASDAQ: SPRB) names rare-disease veteran Keli Walbert to board - Stock Titan

Dec 15, 2025
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Dec 15, 2025

Spruce Biosciences (SPRB) adds Keli Walbert to board with cash and equity pay - Stock Titan

Dec 15, 2025
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Dec 12, 2025

CEO Szwarcberg Acquires 3,524 Of Spruce Biosciences Inc [SPRB] - TradingView — Track All Markets

Dec 12, 2025
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Dec 12, 2025

[8-K] SPRUCE BIOSCIENCES, INC. Reports Material Event | SPRB SEC FilingForm 8-K - Stock Titan

Dec 12, 2025
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Dec 12, 2025

Spruce Biosciences (SPRB) insider RSU vesting and tax share withholding - Stock Titan

Dec 12, 2025
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Dec 11, 2025

Stock Ratings | Guggenheim maintained its "buy" recommendation on Cybin Inc. Common Shares (CYBN) and raised its price target to $48 from $39, representing a potential upside of 378.12%. - Sahm

Dec 11, 2025
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Dec 07, 2025

Spruce Biosciences (SPRB) price target increased by 55.76% to 213.69 - MSN

Dec 07, 2025
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Dec 06, 2025

Wall Street Zen Upgrades Spruce Biosciences (NASDAQ:SPRB) to Hold - MarketBeat

Dec 06, 2025
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Dec 06, 2025

Spruce Biosciences (SPRB) Price Target Increased by 55.76% to 213.69 - Nasdaq

Dec 06, 2025
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Dec 05, 2025

Spruce Biosciences (NASDAQ:SPRB) Raised to Strong-Buy at Leerink Partnrs - MarketBeat

Dec 05, 2025
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Dec 04, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded to "Outperform" at Leerink Partners - MarketBeat

Dec 04, 2025
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Dec 03, 2025

Leerink Partners Upgrades Spruce Biosciences (SPRB) - Nasdaq

Dec 03, 2025
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Dec 03, 2025

Spruce Biosciences Shares Rise After Upgrade From Leerink - marketscreener.com

Dec 03, 2025
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Dec 03, 2025

SPRB: Leerink Partners Upgrades to Outperform with $160 Target | - GuruFocus

Dec 03, 2025
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Dec 03, 2025

Leerink Partners upgrades Spruce Biosciences stock to Outperform By Investing.com - Investing.com Canada

Dec 03, 2025
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Dec 03, 2025

Leerink Partners upgrades Spruce Biosciences stock to Outperform - Investing.com

Dec 03, 2025
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Dec 02, 2025

Pharma execs reflect on 2025 - Healthcare Brew

Dec 02, 2025
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Dec 01, 2025

After-Hours Spotlight: Jasper, NRx, Unicycive, Spruce, Evaxion, Solana, Protara Gain Post-Close - Nasdaq

Dec 01, 2025
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Nov 23, 2025

Spruce Biosciences, Inc. (NASDAQ:SPRB) Receives Consensus Recommendation of "Hold" from Brokerages - MarketBeat

Nov 23, 2025
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Nov 19, 2025

Spruce Biosciences Inc. (SPRB) Stock Price | Live Quotes & Charts | NASDAQ - StocksToTrade

Nov 19, 2025
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Nov 17, 2025

Spruce Biosciences (SPRB) Price Target Increased by 2,045.14% to 137.19 - Nasdaq

Nov 17, 2025
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Nov 16, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded to "Sell" at Wall Street Zen - MarketBeat

Nov 16, 2025
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Nov 12, 2025

Is Spruce Biosciences Stock Built to Withstand More Downside? - Trefis

Nov 12, 2025
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Nov 12, 2025

Citizens Jmp Forecasts Strong Price Appreciation for Spruce Biosciences (NASDAQ:SPRB) Stock - MarketBeat

Nov 12, 2025
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Nov 11, 2025

Citizens raises Spruce Biosciences stock price target to $259 on MPS IIIB therapy - Investing.com Australia

Nov 11, 2025

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$39.33
price up icon 0.23%
$99.85
price down icon 0.61%
$33.44
price down icon 0.84%
$94.38
price down icon 0.73%
biotechnology ONC
$312.16
price up icon 0.09%
$178.28
price up icon 0.55%
Cap:     |  Volume (24h):