104.94
price up icon0.18%   0.19
after-market After Hours: 104.00 -0.94 -0.90%
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Spruce Biosciences Inc stock is traded at $104.94, with a volume of 107.02K. It is up +0.18% in the last 24 hours and up +1,090% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$104.75
Open:
$101.96
24h Volume:
107.02K
Relative Volume:
0.23
Market Cap:
$59.09M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-111.64
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
-15.72%
1M Performance:
+1,090%
6M Performance:
-86.69%
1Y Performance:
-90.34%
1-Day Range:
Value
$100.00
$109.01
1-Week Range:
Value
$100.00
$121.41
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
104.94 59.03M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
421.67 109.22B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
628.00 67.50B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
423.47 57.35B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ARGX
Argen X Se Adr
831.48 50.87B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
INSM
Insmed Inc
182.77 39.72B 447.02M -1.18B -906.14M -6.1812

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Oct-28-25 Upgrade Citizens JMP Mkt Perform → Mkt Outperform
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

pulisher
08:37 AM

Spruce Biosciences (SPRB) Expected to Announce Earnings on Monday - MarketBeat

08:37 AM
pulisher
Nov 03, 2025

One new option listing and two option delistings on September 5th - MSN

Nov 03, 2025
pulisher
Oct 31, 2025

Small Cap Stocks To Follow TodayOctober 6th - MarketBeat

Oct 31, 2025
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Oct 30, 2025

Spruce Biosciences (SPRB) Price Target Decreased by 37.30% to 6.40 - MSN

Oct 30, 2025
pulisher
Oct 29, 2025

[S-3] SPRUCE BIOSCIENCES, INC. Shelf Registration Statement | SPRB SEC FilingForm S-3 - Stock Titan

Oct 29, 2025
pulisher
Oct 29, 2025

Spruce Biosciences, Inc. (NASDAQ:SPRB) Given Average Rating of "Hold" by Brokerages - MarketBeat

Oct 29, 2025
pulisher
Oct 29, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded to "Outperform" at Citizens Jmp - MarketBeat

Oct 29, 2025
pulisher
Oct 28, 2025

Spruce Biosciences Stock Rallied 1184%Have You Assessed the Risk - Trefis

Oct 28, 2025
pulisher
Oct 28, 2025

JMP Securities Upgrades Spruce Biosciences (SPRB) - Nasdaq

Oct 28, 2025
pulisher
Oct 28, 2025

Cash per share of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView

Oct 28, 2025
pulisher
Oct 28, 2025

SPRB: JMP Securities Upgrades Spruce Biosciences to Market Outpe - GuruFocus

Oct 28, 2025
pulisher
Oct 28, 2025

Spruce Biosciences Raised to Market Outperform From Market Perform by JMP Securities - 富途牛牛

Oct 28, 2025
pulisher
Oct 28, 2025

Spruce Biosciences stock upgraded by Citizens on promising MPS IIIB therapy - Investing.com Nigeria

Oct 28, 2025
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Oct 27, 2025

Spruce Biosciences Stock Dropped 16%Have You Assessed the Risk - Trefis

Oct 27, 2025
pulisher
Oct 26, 2025

Spruce Biosciences (NASDAQ:SPRB) Stock Rating Lowered by Zacks Research - MarketBeat

Oct 26, 2025
pulisher
Oct 24, 2025

What is Leerink Partnrs' Forecast for SPRB FY2025 Earnings? - MarketBeat

Oct 24, 2025
pulisher
Oct 24, 2025

Levi & Korsinsky Reminds Spruce Biosciences Investors of the Ongoing Investigation into Potential Violations of Securities LawsSPRB - ACCESS Newswire

Oct 24, 2025
pulisher
Oct 22, 2025

Spruce Biosciences CFO vests 2,053 RSUs; owns 6,066 shares - Stock Titan

Oct 22, 2025
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Oct 22, 2025

SPRB insider filing: CEO nets 3,245 shares after RSU vest - Stock Titan

Oct 22, 2025
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Oct 22, 2025

The science behind the therapy that catapulted a biopharma’s stock 1,400% and counting - Healthcare Brew

Oct 22, 2025
pulisher
Oct 22, 2025

Leerink Partners Maintains Spruce Biosciences (SPRB) Market Perform Recommendation - Nasdaq

Oct 22, 2025
pulisher
Oct 21, 2025

Spruce Biosciences (SPRB): Analyst Raises Price Target Significa - GuruFocus

Oct 21, 2025
pulisher
Oct 21, 2025

Spruce Biosciences stock price target raised to $160 from $10 at Leerink - Investing.com Philippines

Oct 21, 2025
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Oct 20, 2025

Spruce Biosciences (SPRB) Skyrockets 1,300% on FDA Breakthrough – Inside the Stock Surge, Pipeline & Outlook (Oct 2025) - ts2.tech

Oct 20, 2025
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Oct 20, 2025

Mintz Advises the Placement Agents in Spruce Biosciences, Inc.’s $50 Million Private Placement - Mintz

Oct 20, 2025
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Oct 19, 2025

Spruce Biosciences (SPRB) Skyrockets 1,300% on FDA Breakthrough News – Experts Weigh In - ts2.tech

Oct 19, 2025
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Oct 19, 2025

Spruce Biosciences (NASDAQ:SPRB) Upgraded at Zacks Research - Defense World

Oct 19, 2025
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Oct 18, 2025

SPRUCE BIOSCIENCES, INC. trading resumes - MSN

Oct 18, 2025
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Oct 18, 2025

Spruce Biosciences (NASDAQ:SPRB) Rating Increased to Strong-Buy at Zacks Research - MarketBeat

Oct 18, 2025
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Oct 17, 2025

SPRB director steps down; company notes no disagreement - Stock Titan

Oct 17, 2025
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Oct 17, 2025

Spruce Biosciences, Inc. Announces Resignation of Bali Muralidhar as Member of Board of Directors and as Member of the Compensation Committee of the Board, Effective October 15, 2025 - MarketScreener

Oct 17, 2025
pulisher
Oct 16, 2025

Spruce Biosciences Stock More Than Quadruples After Breakthrough Therapy Designation To Therapy For Rare And Fatal Genetic Disease - MSN

Oct 16, 2025
pulisher
Oct 16, 2025

Head to Head Contrast: PyroGenesis Canada (NASDAQ:PYRGF) vs. Spruce Biosciences (NASDAQ:SPRB) - Defense World

Oct 16, 2025
pulisher
Oct 15, 2025

What Makes Spruce Biosciences, Inc. (SPRB) a Strong Momentum Stock: Buy Now? - sharewise.com

Oct 15, 2025
pulisher
Oct 15, 2025

Spruce Biosciences’ (SPRB) “Sell (D-)” Rating Reaffirmed at Weiss Ratings - Defense World

Oct 15, 2025
pulisher
Oct 15, 2025

Spruce Biosciences insider filing shows 256-share buy, 1,050 held - Stock Titan

Oct 15, 2025
pulisher
Oct 14, 2025

Spruce Biosciences to sell 502,181 shares at $68.00 in private placement - MSN

Oct 14, 2025
pulisher
Oct 14, 2025

Spruce Biosciences' (SPRB) "Sell (D-)" Rating Reaffirmed at Weiss Ratings - MarketBeat

Oct 14, 2025
pulisher
Oct 11, 2025

Spruce Biosciences (NASDAQ:SPRB) Shares Down 1%What's Next? - MarketBeat

Oct 11, 2025
pulisher
Oct 11, 2025

Spruce Biosciences (NASDAQ:SPRB) Shares Down 1% – What’s Next? - Defense World

Oct 11, 2025
pulisher
Oct 09, 2025

Medical Stocks To ConsiderOctober 6th - MarketBeat

Oct 09, 2025
pulisher
Oct 09, 2025

Promising Pharmaceutical Stocks Worth WatchingOctober 6th - MarketBeat

Oct 09, 2025
pulisher
Oct 09, 2025

$SPRB stock is down 11% today. Here's what we see in our data. - Quiver Quantitative

Oct 09, 2025
pulisher
Oct 08, 2025

Spruce Biosciences, Inc. announced that it has received $49.999769 million in funding - MarketScreener

Oct 08, 2025
pulisher
Oct 08, 2025

Parkman healthcare sells Spruce Biosciences (SPRB) shares for $4920 By Investing.com - Investing.com Canada

Oct 08, 2025
pulisher
Oct 08, 2025

Parkman healthcare sells Spruce Biosciences (SPRB) shares for $4920 - Investing.com India

Oct 08, 2025
pulisher
Oct 08, 2025

SPRUCE BIOSCIENCES, INC. trading halted, volatility trading pause - MSN

Oct 08, 2025
pulisher
Oct 08, 2025

Spruce Biosciences announces $50M private placement financing - TipRanks

Oct 08, 2025
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Oct 08, 2025

Spruce Biosciences (SPRB) Secures $50M for Therapy Advancements - GuruFocus

Oct 08, 2025
pulisher
Oct 08, 2025

Three Biotech Stocks Jump After Big Regulatory Wins - Finimize

Oct 08, 2025
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Oct 08, 2025

Spruce Biosciences (SPRB) Secures $50M for Enzyme Replacement Th - GuruFocus

Oct 08, 2025

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$37.84
price up icon 1.45%
$28.76
price up icon 0.17%
$102.92
price up icon 1.33%
$104.83
price up icon 0.84%
biotechnology ONC
$309.19
price down icon 0.86%
$182.77
price down icon 1.86%
Cap:     |  Volume (24h):