2.91
price up icon2.11%   0.06
pre-market  Pre-market:  2.95   0.04   +1.37%
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Spero Therapeutics Inc stock is traded at $2.91, with a volume of 932.50K. It is up +2.11% in the last 24 hours and up +4.30% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.85
Open:
$2.93
24h Volume:
932.50K
Relative Volume:
1.62
Market Cap:
$168.49M
Revenue:
$54.77M
Net Income/Loss:
$15.24M
P/E Ratio:
11.95
EPS:
0.2436
Net Cash Flow:
$7.24M
1W Performance:
+6.20%
1M Performance:
+4.30%
6M Performance:
+27.07%
1Y Performance:
+2.83%
1-Day Range:
Value
$2.85
$2.966
1-Week Range:
Value
$2.48
$2.966
52-Week Range:
Value
$1.80
$3.22

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
25
Name
Twitter
@spero_tx
Name
Next Earnings Date
2026-05-13
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SPRO icon
SPRO
Spero Therapeutics Inc
2.91 168.49M 54.77M 15.24M 7.24M 0.2436
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
450.46 114.33B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
614.98 64.47B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
884.20 54.99B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
287.80 38.42B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
160.06 34.03B 742.00K -1.37B -1.07B -7.0731

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
08:03 AM

Spero Therapeutics Stock (US85208T1079): Quiet session keeps focus on fundamentals and pipeline - AD HOC NEWS

08:03 AM
pulisher
Jun 11, 2026

SPRO News | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

Jun 11, 2026
pulisher
Jun 08, 2026

Spero Therapeutics: Approval Upside, Commercial Friction (Initiating Hold) - Seeking Alpha

Jun 08, 2026
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Jun 05, 2026

Spero Therapeutics Q1 2026 Earnings: Narrower Loss Beats Estimates, but Stock Falls Amid Lack of Revenue - newsline.com

Jun 05, 2026
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May 31, 2026

MSN Money - MSN

May 31, 2026
pulisher
May 29, 2026

Spero Therapeutics (SPRO) Slips 2.41% as Stock Tests Key Support at $2.69Dark Pool Volume - newsline.com

May 29, 2026
pulisher
May 28, 2026

Spero Therapeutics (SPRO) Hovers Near Support Amid Modest Decline – Key Levels in FocusCorrective Wave - The Legal Advocate

May 28, 2026
pulisher
May 27, 2026

Spero Therapeutics (SPRO) Jumps 4.9% as Stock Approaches Key Resistance at $3.15Oversold Bounce Ideas - The Legal Advocate

May 27, 2026
pulisher
May 22, 2026

SPRO Technical Analysis | Trend, Signals & Chart Patterns | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

May 22, 2026
pulisher
May 21, 2026

Spero Therapeutics (SPRO) Q1 2026 Earnings: Why the Beat MattersCEO Earnings Statement - Newser

May 21, 2026
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May 17, 2026

Spero Therapeutics, Inc. Common Stock (SPRO) Stock Price Today & Analysis - Gotrade

May 17, 2026
pulisher
May 15, 2026

Promising Penny Stocks To Consider In May 2026 - simplywall.st

May 15, 2026
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May 13, 2026

Is Spero Therapeutics (SPRO) 110.3% Overvalued After Q1 2026 Ear - GuruFocus

May 13, 2026
pulisher
May 13, 2026

Spero Therapeutics 1Q Loss $7.2M >SPRO - Moomoo

May 13, 2026
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May 13, 2026

Spero Therapeutics Q1 revenue drops on decreased clinical activity - TradingView

May 13, 2026
pulisher
May 13, 2026

Spero Therapeutics Announces First Quarter 2026 Operating Results and Provides Business Update - The Manila Times

May 13, 2026
pulisher
May 13, 2026

Spero Therapeutics (NASDAQ: SPRO) leans on GSK-partnered tebipenem ahead June 2026 FDA date - Stock Titan

May 13, 2026
pulisher
May 13, 2026

Spero Therapeutics, Inc. Reports Earnings Results for the First Quarter Ended March 31, 2026 - marketscreener.com

May 13, 2026
pulisher
May 13, 2026

Spero Therapeutics (SPRO) trims Q1 2026 loss ahead key tebipenem FDA date - Stock Titan

May 13, 2026
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May 12, 2026

TradingKey - TradingKey

May 12, 2026
pulisher
May 09, 2026

Number of shareholders of Spero Therapeutics, Inc. – NASDAQ:SPRO - TradingView

May 09, 2026
pulisher
May 08, 2026

SPRO SEC FilingsSpero Therapeuti 10-K, 10-Q, 8-K Forms - Stock Titan

May 08, 2026
pulisher
May 07, 2026

SPRO FINAL DEADLINE TODAY: ROSEN, A GLOBALLY RECOGNIZED FIRM, Encourages Spero Therapeutics, Inc. Investors with Losses to Secure Counsel Before Important July 25 Deadline in Securities Class ActionSPRO - TMX Newsfile

May 07, 2026
pulisher
May 07, 2026

Spero Therapeutics CEO sells $63,352 in company stock By Investing.com - Investing.com Australia

May 07, 2026
pulisher
May 06, 2026

Spero Therapeutics (SPRO) officer sells shares for RSU tax obligations - Stock Titan

May 06, 2026
pulisher
May 06, 2026

Spero Therapeutics CEO sells $63,352 in company stock - Investing.com India

May 06, 2026
pulisher
May 05, 2026

SPRO: The fleeting Sparrow - Moomoo

May 05, 2026
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May 05, 2026

No call planned as Spero sets May 13 for Q1 results update - Stock Titan

May 05, 2026
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May 05, 2026

Spero Therapeutics to Report First Quarter 2026 Financial Results and Provide Business Update on May 13, 2026 - GlobeNewswire

May 05, 2026
pulisher
May 01, 2026

SPRO Stock Price, Quote & Chart | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

May 01, 2026
pulisher
Apr 30, 2026

Spero Therapeutics, Inc. (NASDAQ:SPRO) Sees Significant Growth in Short Interest - MarketBeat

Apr 30, 2026
pulisher
Apr 27, 2026

Best Momentum Stock to Buy for October 10th - MSN

Apr 27, 2026
pulisher
Apr 27, 2026

Spero Therapeutics (NASDAQ: SPRO) 2026 proxy adds stock increase and new incentive plan - Stock Titan

Apr 27, 2026
pulisher
Apr 27, 2026

Spero Therapeutics (SPRO) price target decreased by 20.00% to 4.08 - MSN

Apr 27, 2026
pulisher
Apr 27, 2026

[ARS] Spero Therapeutics, Inc. SEC Filing - Stock Titan

Apr 27, 2026
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Apr 25, 2026

ROSEN, Top Ranked Investor Counsel, Encourages Spero Therapeutics, Inc. Investors with Losses to Secure Counsel Before Important Deadline in Securities Class ActionSPRO - TMX Newsfile

Apr 25, 2026
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Apr 20, 2026

Spero Therapeutics (SPRO) Stock Volume Spike Alert (Builds on Momentum) 2026-04-20Open Stock Picks - Cổng thông tin điện tử tỉnh Lào Cai

Apr 20, 2026
pulisher
Apr 18, 2026

Spero Therapeutics (SPRO) Stock Insider Buying (Market Focus) 2026-04-18Algo Picks - Cổng thông tin điện tử tỉnh Lào Cai

Apr 18, 2026
pulisher
Apr 17, 2026

SPRO Forecast, Price Target & Analyst Ratings | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

Apr 17, 2026
pulisher
Apr 16, 2026

Spero Therapeutics Stock Rises Above 50-Day Moving Average - National Today

Apr 16, 2026
pulisher
Apr 16, 2026

Spero Therapeutics (NASDAQ:SPRO) Share Price Passes Above 50 Day Moving AverageWhat's Next? - MarketBeat

Apr 16, 2026

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$97.46
price down icon 0.40%
$30.03
price down icon 0.03%
$90.80
price up icon 0.29%
$54.27
price down icon 1.09%
ONC ONC
$268.20
price up icon 1.41%
$160.06
price up icon 4.02%
Cap:     |  Volume (24h):