2.38
price up icon0.42%   0.010
after-market After Hours: 2.38
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Spero Therapeutics Inc stock is traded at $2.38, with a volume of 104.19K. It is up +0.42% in the last 24 hours and down -5.18% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. Besides, it is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.37
Open:
$2.37
24h Volume:
104.19K
Relative Volume:
0.31
Market Cap:
$134.09M
Revenue:
$76.19M
Net Income/Loss:
$-1.61M
P/E Ratio:
238.00
EPS:
0.01
Net Cash Flow:
$28.98M
1W Performance:
+3.48%
1M Performance:
-5.18%
6M Performance:
+0.85%
1Y Performance:
+195.14%
1-Day Range:
Value
$2.315
$2.41
1-Week Range:
Value
$2.275
$2.43
52-Week Range:
Value
$0.5052
$3.22

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
32
Name
Twitter
@spero_tx
Name
Next Earnings Date
2025-03-19
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRO
Spero Therapeutics Inc
2.38 133.52M 76.19M -1.61M 28.98M 0.01
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
465.02 117.03B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
783.65 82.35B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
833.54 51.64B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
308.48 42.58B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
346.42 38.87B 4.98B 69.60M 525.67M 0.5198

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
Feb 11, 2026

Spero Therapeutics: Tebipenem’s FDA Path Supports A Speculative Buy (NASDAQ:SPRO) - Seeking Alpha

Feb 11, 2026
pulisher
Feb 09, 2026

Esther Rajavelu Sells 87,917 Shares of Spero Therapeutics (NASDAQ:SPRO) Stock - MarketBeat

Feb 09, 2026
pulisher
Feb 09, 2026

Keutzer, Spero Therapeutics COO, sells $44k in shares - Investing.com

Feb 09, 2026
pulisher
Feb 09, 2026

Spero Therapeutics CEO sells $207k in stock By Investing.com - Investing.com Canada

Feb 09, 2026
pulisher
Feb 09, 2026

Keutzer, Spero Therapeutics COO, sells $44k in shares By Investing.com - Investing.com Canada

Feb 09, 2026
pulisher
Feb 09, 2026

Spero Therapeutics CEO sells $207k in stock - Investing.com

Feb 09, 2026
pulisher
Feb 06, 2026

Aug Breakouts: What drives Spero Therapeutics Incs stock priceEarnings Summary Report & Safe Entry Zone Tips - baoquankhu1.vn

Feb 06, 2026
pulisher
Feb 05, 2026

Spero Therapeutics (NASDAQ:SPRO) Insider Sells 18,442 Shares - MarketBeat

Feb 05, 2026
pulisher
Feb 05, 2026

Spero Therapeutics (NASDAQ:SPRO) Stock Price Crosses Below 200 Day Moving AverageWhat's Next? - MarketBeat

Feb 05, 2026
pulisher
Feb 04, 2026

Spero therapeutics exec Rajavelu sells $40k in shares By Investing.com - Investing.com Australia

Feb 04, 2026
pulisher
Feb 04, 2026

Spero therapeutics exec Rajavelu sells $40k in shares - Investing.com

Feb 04, 2026
pulisher
Jan 31, 2026

Spero Therapeutics announces board resignation and SEC investigation closure By Investing.com - Investing.com Nigeria

Jan 31, 2026
pulisher
Jan 30, 2026

Spero Therapeutics Co-Founder Resigns From Board Roles - TipRanks

Jan 30, 2026
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Jan 30, 2026

SEC ends Spero Therapeutics (NASDAQ: SPRO) probe as director steps down - Stock Titan

Jan 30, 2026
pulisher
Jan 30, 2026

SEC Enforcement Action Against Former Spero Executives: Individual Liability For Misleading FDA-Related Disclosures - marketscreener.com

Jan 30, 2026
pulisher
Jan 20, 2026

SEC Settlement Resolves Past Disclosure Issues for Spero Therapeutics - AD HOC NEWS

Jan 20, 2026
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Jan 19, 2026

Spero Therapeutics announces inducement grant under Nasdaq listing rule - MSN

Jan 19, 2026
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Jan 14, 2026

Momentum Shift: What is Spero Therapeutics Incs valuation compared to sector2025 Performance Recap & Daily Profit Maximizing Tips - baoquankhu1.vn

Jan 14, 2026
pulisher
Jan 13, 2026

Insider Buy: Is Spero Therapeutics Inc stock overvalued by current metricsJuly 2025 EndofMonth & Low Drawdown Investment Ideas - Bộ Nội Vụ

Jan 13, 2026
pulisher
Jan 13, 2026

Stock Market Recap: Will Spero Therapeutics Inc. stock reach all time highs in 20252025 Trading Volume Trends & Stock Portfolio Risk Management - Bộ Nội Vụ

Jan 13, 2026
pulisher
Jan 11, 2026

Spero Therapeutics (NASDAQ:SPRO) Raised to "Buy" at Wall Street Zen - MarketBeat

Jan 11, 2026
pulisher
Jan 08, 2026

Will Spero Therapeutics Inc. (2HA) stock sustain bullish trend into 2025 - ulpravda.ru

Jan 08, 2026
pulisher
Jan 08, 2026

Is Spero Therapeutics Inc. (2HA) stock protected from inflationJuly 2025 Levels & Fast Gain Swing Trade Alerts - ulpravda.ru

Jan 08, 2026
pulisher
Jan 08, 2026

Will Spero Therapeutics Inc. stock benefit from upcoming earnings reports2025 Trade Ideas & Free Expert Verified Stock Movement Alerts - Улправда

Jan 08, 2026
pulisher
Jan 07, 2026

3 Promising Penny Stocks With Market Caps Up To $300M - simplywall.st

Jan 07, 2026
pulisher
Jan 03, 2026

Spero Therapeutics (NASDAQ:SPRO) Downgraded by Wall Street Zen to Hold - MarketBeat

Jan 03, 2026
pulisher
Jan 02, 2026

What analysts say about Spero Therapeutics Inc stockLong-Term Growth Stocks & Free Unmatched Market Gains - earlytimes.in

Jan 02, 2026
pulisher
Dec 31, 2025

Spero Therapeutics (NASDAQ:SPRO) Stock Crosses Below 200-Day Moving Average – Here’s What Happened - Defense World

Dec 31, 2025
pulisher
Dec 31, 2025

Spero Therapeutics (NASDAQ:SPRO) Stock Crosses Below 200-Day Moving AverageHere's What Happened - MarketBeat

Dec 31, 2025
pulisher
Dec 31, 2025

Spero Therapeutics, Inc. (NASDAQ:SPRO) Sees Large Growth in Short Interest - MarketBeat

Dec 31, 2025
pulisher
Dec 28, 2025

Book value per share of Spero Therapeutics, Inc. – BER:2HA - TradingView — Track All Markets

Dec 28, 2025
pulisher
Dec 23, 2025

Spero Therapeutics (STU:2HA) EV-to-OCF : -2.75 (As of Dec. 24, 2025) - GuruFocus

Dec 23, 2025
pulisher
Dec 23, 2025

Spero Therapeutics (NASDAQ:SPRO) Stock Price Crosses Below 200 Day Moving Average – Time to Sell? - Defense World

Dec 23, 2025
pulisher
Dec 20, 2025

Will Spero Therapeutics Inc. stock reach all time highs in 2025Inflation Watch & Growth Oriented Trade Recommendations - Улправда

Dec 20, 2025
pulisher
Dec 20, 2025

Stop Loss: Will Spero Therapeutics Inc. stock reach all time highs in 2025Inflation Watch & Reliable Price Breakout Signals - ulpravda.ru

Dec 20, 2025
pulisher
Dec 19, 2025

GSK, Spero Therapeutics resubmits NDA for tebipenem HBr as oral option for complicated urinary tract infections - Contemporary OB/GYN

Dec 19, 2025
pulisher
Dec 19, 2025

GSK Resubmits NDA, Triggering Milestone for Spero Therapeutics - TipRanks

Dec 19, 2025
pulisher
Dec 19, 2025

Spero Therapeutics Announces NDA Resubmission for Tebipenem HBr - TradingView — Track All Markets

Dec 19, 2025
pulisher
Dec 19, 2025

Spero Therapeutics Announces GSK's NDA Resubmission for Tebipenem HBr, Triggering $25 Million Milestone Payment - Quiver Quantitative

Dec 19, 2025
pulisher
Dec 19, 2025

Spero Announces NDA Resubmission of Tebipenem HBr by GSK to - GlobeNewswire

Dec 19, 2025
pulisher
Dec 19, 2025

How geopolitical risks impact Spero Therapeutics Inc. (2HA) stockMarket Performance Report & Short-Term Trading Opportunity Alerts - DonanımHaber

Dec 19, 2025
pulisher
Dec 15, 2025

Total debt per share of Spero Therapeutics, Inc. – FWB:2HA - TradingView — Track All Markets

Dec 15, 2025
pulisher
Dec 15, 2025

Is Spero Therapeutics (NASDAQ:SPRO) In A Good Position To Deliver On Growth Plans? - Yahoo Finance

Dec 15, 2025
pulisher
Dec 14, 2025

Spero Therapeutics (SPRO) price target decreased by 20.00% to 4.08 - MSN

Dec 14, 2025
pulisher
Dec 14, 2025

Spero Therapeutics (NASDAQ:SPRO) Upgraded to "Buy" at Wall Street Zen - MarketBeat

Dec 14, 2025
pulisher
Dec 06, 2025

Spero Therapeutics, Inc. (SPRO) Reports Q1 Loss, Misses Revenue Estimates - sharewise.com

Dec 06, 2025
pulisher
Dec 06, 2025

Spero Therapeutics (NASDAQ:SPRO) Stock Rating Lowered by Wall Street Zen - MarketBeat

Dec 06, 2025
pulisher
Dec 04, 2025

Can Spero Therapeutics Inc. (2HA) stock test all time highsMarket Risk Report & Free Low Drawdown Momentum Trade Ideas - Newser

Dec 04, 2025
pulisher
Dec 04, 2025

Will Spero Therapeutics Inc. (2HA) stock benefit from sector leadership2025 Top Gainers & Free Weekly Watchlist of Top Performers - Newser

Dec 04, 2025
pulisher
Dec 04, 2025

Why Spero Therapeutics Inc. stock is popular among millennials2025 Market Overview & Community Consensus Picks - Newser

Dec 04, 2025

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$44.80
price up icon 1.24%
$26.75
price down icon 0.19%
$100.75
price up icon 1.93%
$105.76
price down icon 3.31%
$146.17
price down icon 1.52%
biotechnology ONC
$346.42
price down icon 1.38%
Cap:     |  Volume (24h):