2.64
price down icon5.04%   -0.14
after-market After Hours: 2.64
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Spero Therapeutics Inc stock is traded at $2.64, with a volume of 693.53K. It is down -5.04% in the last 24 hours and up +2.33% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.78
Open:
$2.78
24h Volume:
693.53K
Relative Volume:
2.00
Market Cap:
$152.83M
Revenue:
$59.62M
Net Income/Loss:
$8.57M
P/E Ratio:
22.18
EPS:
0.119
Net Cash Flow:
$-12.62M
1W Performance:
-2.94%
1M Performance:
+2.33%
6M Performance:
+6.02%
1Y Performance:
+254.65%
1-Day Range:
Value
$2.63
$2.80
1-Week Range:
Value
$2.625
$2.88
52-Week Range:
Value
$0.57
$3.22

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
25
Name
Twitter
@spero_tx
Name
Next Earnings Date
2026-03-26
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SPRO icon
SPRO
Spero Therapeutics Inc
2.64 160.94M 59.62M 8.57M -12.62M 0.119
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
441.70 113.01B 12.07B 3.95B 3.19B 15.33
REGN icon
REGN
Regeneron Pharmaceuticals Inc
753.93 79.87B 14.34B 4.50B 3.77B 41.56
ARGX icon
ARGX
Argen X Se Adr
840.87 51.51B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
333.39 45.29B 3.71B 313.75M 465.38M 2.2571
ONC icon
ONC
Beone Medicines Ltd Adr
319.94 34.41B 5.36B 287.73M 924.18M 2.5229

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
Apr 13, 2026

Spero Therapeutics (NASDAQ: SPRO) asks shareholders to double authorized shares to 240M - Stock Titan

Apr 13, 2026
pulisher
Apr 11, 2026

Portfolio Shifts: Is Spero Therapeutics Inc stock showing strong momentum2026 Rallies & AI Forecasted Entry/Exit Points - baoquankhu1.vn

Apr 11, 2026
pulisher
Apr 10, 2026

MACD Signal: Does Spero Therapeutics Inc have pricing power2026 Growth vs Value & Verified Swing Trading Watchlist - baoquankhu1.vn

Apr 10, 2026
pulisher
Apr 09, 2026

Non Tuberculous Mycobacterial Infections Market: High-Growth Opportunities for Investors to 2034 – DelveInsight | Insmed, AN2 Therapeutics, Mannkind Corp., Spero Therapeutics, Savara Pharmaceuticals - Barchart.com

Apr 09, 2026
pulisher
Apr 08, 2026

Spero Therapeutics (SPRO) price target decreased by 20.00% to 4.08 - MSN

Apr 08, 2026
pulisher
Apr 08, 2026

Market Overview: Will Spero Therapeutics Inc benefit from seasonality2026 Pullbacks & Capital Efficiency Focused Ideas - baoquankhu1.vn

Apr 08, 2026
pulisher
Apr 08, 2026

Market Review: What is the PEG ratio of Spero Therapeutics IncInflation Watch & Safe Capital Growth Stock Tips - baoquankhu1.vn

Apr 08, 2026
pulisher
Apr 07, 2026

Spero Therapeutics Stock Rises Above 50-Day Average - National Today

Apr 07, 2026
pulisher
Apr 07, 2026

Spero Therapeutics (NASDAQ:SPRO) Stock Price Passes Above 50-Day Moving AverageTime to Sell? - MarketBeat

Apr 07, 2026
pulisher
Apr 06, 2026

SPRO Forecast, Price Target & Analyst Ratings | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

Apr 06, 2026
pulisher
Apr 03, 2026

Spero Therapeutics Secures Financial Stability Through 2028 () - aktiencheck.de

Apr 03, 2026
pulisher
Mar 29, 2026

Spero Therapeutics (NASDAQ:SPRO) Upgraded by Wall Street Zen to "Strong-Buy" Rating - MarketBeat

Mar 29, 2026
pulisher
Mar 28, 2026

Spero Therapeutics (NASDAQ:SPRO) versus Mereo BioPharma Group (NASDAQ:MREO) Financial Contrast - Defense World

Mar 28, 2026
pulisher
Mar 27, 2026

Best Momentum Stock to Buy for October 10th - MSN

Mar 27, 2026
pulisher
Mar 27, 2026

Spero Therapeutics (SPRO) Earnings Turn Positive Challenging Bearish Profitability Narratives - Sahm

Mar 27, 2026
pulisher
Mar 26, 2026

Spero Therapeutics shares jump over 4% on better-than-expected Q4 print - Investing.com

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics Announces Fourth Quarter and Full Year 2025 Operating Results and Provides a Business Update - Bitget

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics earnings beat by $0.73, revenue topped estimates - Investing.com Canada

Mar 26, 2026
pulisher
Mar 26, 2026

SPERO THERAPEUTICS ($SPRO) Releases Q4 2025 Earnings - Quiver Quantitative

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics (NASDAQ:SPRO) Posts Earnings Results, Beats Estimates By $0.73 EPS - MarketBeat

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics Q4 revenue nearly triples, swings to profit - TradingView

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics 2025 10-K: $66.8M Revenue, $0.15 EPS - TradingView

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics (NASDAQ: SPRO) turns 2025 profit as tebipenem advances - Stock Titan

Mar 26, 2026
pulisher
Mar 26, 2026

BRIEF-Spero Therapeutics Q4 EPS USD 0.56 - TradingView

Mar 26, 2026
pulisher
Mar 26, 2026

[10-K] Spero Therapeutics, Inc. Files Annual Report - Stock Titan

Mar 26, 2026
pulisher
Mar 26, 2026

Can Spero Therapeutics Inc sustain earnings growth2026 Macro Impact & Risk Adjusted Buy and Sell Alerts - baoquankhu1.vn

Mar 26, 2026
pulisher
Mar 26, 2026

Spero Therapeutics shares jump over 4% on better-than-expected Q4 print By Investing.com - Investing.com South Africa

Mar 26, 2026
pulisher
Mar 24, 2026

Down 17.7% in 4 Weeks, Here's Why Spero Therapeutics (SPRO) Looks Ripe for a Turnaround - MSN

Mar 24, 2026
pulisher
Mar 23, 2026

Analyst Calls: Is Spero Therapeutics Inc stock showing strong momentumWeekly Gains Summary & Fast Moving Stock Watchlists - baoquankhu1.vn

Mar 23, 2026
pulisher
Mar 22, 2026

If You Invested $1,000 in Spero Therapeuti (SPRO) - Stock Titan

Mar 22, 2026
pulisher
Mar 21, 2026

Spero Therapeutics (NASDAQ:SPRO) Downgraded by Wall Street Zen to "Hold" - MarketBeat

Mar 21, 2026
pulisher
Mar 21, 2026

Spero Therapeutics (SPRO.US) will release its earnings report after the market closes on March 26. - 富途牛牛

Mar 21, 2026
pulisher
Mar 20, 2026

SPRO Stock Price, Quote & Chart | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

Mar 20, 2026
pulisher
Mar 19, 2026

Activity Recap: Is Spero Therapeutics Inc stock showing strong momentumPortfolio Gains Summary & Fast Gain Stock Tips - baoquankhu1.vn

Mar 19, 2026
pulisher
Mar 19, 2026

Spero Therapeutics (SPRO) Expected to Announce Earnings on Thursday - MarketBeat

Mar 19, 2026
pulisher
Mar 18, 2026

Spero Therapeutics Inc 預計每股虧損 55 美分財報前瞻 - TradingView

Mar 18, 2026
pulisher
Mar 18, 2026

Spero Therapeutics to Report Fourth Quarter and Full Year 2025 Financial Results and Provide Business Update on March 26, 2026 - marketscreener.com

Mar 18, 2026
pulisher
Mar 18, 2026

Spero Therapeutics to Report Fourth Quarter and Full Year - GlobeNewswire

Mar 18, 2026
pulisher
Mar 18, 2026

Spero Therapeutics to post Q4 and 2025 results on March 26 - Stock Titan

Mar 18, 2026
pulisher
Mar 16, 2026

Weekly Earnings: What are Spero Therapeutics Incs recent SEC filings showingQuarterly Trade Report & Capital Efficient Trading Techniques - baoquankhu1.vn

Mar 16, 2026
pulisher
Mar 15, 2026

Spero Therapeutics, Inc. (NASDAQ:SPRO) Sees Large Decline in Short Interest - MarketBeat

Mar 15, 2026
pulisher
Mar 12, 2026

Profit Recap: Is Spero Therapeutics Inc stock showing strong momentumStop Loss & Weekly High Conviction Trade Ideas - baoquankhu1.vn

Mar 12, 2026
pulisher
Mar 12, 2026

Spero Therapeutics Inc erwartet einen Verlust von 55 Cents pro AktieEarnings Preview - TradingView

Mar 12, 2026
pulisher
Mar 07, 2026

Dow Update: Can Spero Therapeutics Inc lead its sector in growth2025 Earnings Impact & Free High Return Stock Watch Alerts - baoquankhu1.vn

Mar 07, 2026
pulisher
Mar 07, 2026

Stock Recap: Can Spero Therapeutics Inc ride the EV waveMarket Movers & Daily Chart Pattern Signals - baoquankhu1.vn

Mar 07, 2026
pulisher
Mar 06, 2026

Big Picture: Will Spero Therapeutics Inc benefit from seasonalityWeekly Profit Summary & Weekly Market Pulse Alerts - baoquankhu1.vn

Mar 06, 2026
pulisher
Mar 04, 2026

SPRO SEC FilingsSpero Therapeuti 10-K, 10-Q, 8-K Forms - Stock Titan

Mar 04, 2026
pulisher
Mar 02, 2026

Short Interest in Spero Therapeutics, Inc. (NASDAQ:SPRO) Declines By 24.0% - MarketBeat

Mar 02, 2026
pulisher
Feb 27, 2026

SPRO Earning Date, Earning Analysis and Earning Prediction - Intellectia AI

Feb 27, 2026
pulisher
Feb 25, 2026

Spero Therapeutics (NASDAQ:SPRO) Shares Pass Above 200-Day Moving AverageShould You Sell? - MarketBeat

Feb 25, 2026
pulisher
Feb 21, 2026

Can Spero Therapeutics Inc. (2HA) stock sustain margin levels2025 Trading Recap & Fast Entry Momentum Trade Alerts - mfd.ru

Feb 21, 2026

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$54.26
price up icon 2.69%
$48.70
price down icon 0.25%
$99.47
price up icon 1.08%
$152.54
price up icon 3.76%
$146.74
price down icon 4.34%
ONC ONC
$319.94
price up icon 3.21%
Cap:     |  Volume (24h):