2.29
price up icon1.78%   0.04
after-market After Hours: 2.24 -0.05 -2.18%
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Spero Therapeutics Inc stock is traded at $2.29, with a volume of 551.71K. It is up +1.78% in the last 24 hours and up +20.53% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. Besides, it is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.25
Open:
$2.35
24h Volume:
551.71K
Relative Volume:
1.02
Market Cap:
$128.87M
Revenue:
$76.19M
Net Income/Loss:
$-1.61M
P/E Ratio:
229.00
EPS:
0.01
Net Cash Flow:
$28.98M
1W Performance:
+9.57%
1M Performance:
+20.53%
6M Performance:
+281.67%
1Y Performance:
+83.20%
1-Day Range:
Value
$2.24
$2.41
1-Week Range:
Value
$2.0614
$2.42
52-Week Range:
Value
$0.5052
$3.22

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
32
Name
Twitter
@spero_tx
Name
Next Earnings Date
2025-03-19
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRO
Spero Therapeutics Inc
2.29 126.62M 76.19M -1.61M 28.98M 0.01
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
407.37 104.55B 11.39B 3.64B 3.50B 13.99
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ALNY
Alnylam Pharmaceuticals Inc
464.95 60.36B 2.46B -319.09M -52.09M -2.4669
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REGN
Regeneron Pharmaceuticals Inc
557.73 59.84B 14.21B 4.46B 3.56B 39.69
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ARGX
Argen X Se Adr
799.56 49.07B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ONC
Beone Medicines Ltd Adr
327.03 35.16B 4.56B -176.77M 225.30M -1.7177

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
08:29 AM

Forecasting Spero Therapeutics Inc. price range with options dataWeekly Trend Report & Entry Point Strategy Guides - newser.com

08:29 AM
pulisher
01:20 AM

Is Spero Therapeutics Inc a good long term investmentProtective Put Strategies & Amplify Gains With Picks - earlytimes.in

01:20 AM
pulisher
Oct 12, 2025

Is Spero Therapeutics Inc. (2HA) stock positioned for digital growth eraMarket Risk Analysis & Weekly High Potential Stock Alerts - newser.com

Oct 12, 2025
pulisher
Oct 10, 2025

Key resistance and support levels for Spero Therapeutics Inc.Portfolio Gains Report & Stock Timing and Entry Methods - newser.com

Oct 10, 2025
pulisher
Oct 10, 2025

Sector ETF performance correlation with Spero Therapeutics Inc.July 2025 Reactions & Consistent Income Trade Recommendations - newser.com

Oct 10, 2025
pulisher
Oct 10, 2025

Best Momentum Stock to Buy for October 10th - sharewise.com

Oct 10, 2025
pulisher
Oct 09, 2025

Spero Therapeutics' (SPRO) Sell (D-) Rating Reaffirmed at Weiss Ratings - MarketBeat

Oct 09, 2025
pulisher
Oct 08, 2025

What analysts say about Spero Therapeutics Inc stockSell Signals and Alerts & Breakthrough Investment Results - earlytimes.in

Oct 08, 2025
pulisher
Oct 08, 2025

Spero Therapeutics (NASDAQ:SPRO) Rating Increased to Strong-Buy at Zacks Research - MarketBeat

Oct 08, 2025
pulisher
Oct 06, 2025

October 2025's Promising Penny Stocks To Consider - simplywall.st

Oct 06, 2025
pulisher
Oct 06, 2025

Key metrics from Spero Therapeutics Inc.’s quarterly dataWall Street Watch & Low Risk High Reward Ideas - newser.com

Oct 06, 2025
pulisher
Oct 06, 2025

How strong is Spero Therapeutics Inc. stock revenue growth2025 Biggest Moves & AI Driven Stock Reports - newser.com

Oct 06, 2025
pulisher
Oct 05, 2025

Heatmap analysis for Spero Therapeutics Inc. and competitors2025 Institutional Moves & Weekly Breakout Watchlists - newser.com

Oct 05, 2025
pulisher
Oct 05, 2025

Is Spero Therapeutics Inc. (2HA) stock safe for risk averse investors2025 Short Interest & Risk Adjusted Swing Trade Ideas - newser.com

Oct 05, 2025
pulisher
Oct 03, 2025

Spero Therapeutics, Inc. (NASDAQ:SPRO) Receives Consensus Rating of "Hold" from Brokerages - MarketBeat

Oct 03, 2025
pulisher
Oct 03, 2025

Will Spero Therapeutics Inc. see short term momentumTrade Analysis Report & Daily Volume Surge Signals - newser.com

Oct 03, 2025
pulisher
Sep 30, 2025

Spero Therapeutics CEO sells shares worth $121,159 - MSN

Sep 30, 2025
pulisher
Sep 29, 2025

Spero Therapeutics Inc. stock trend forecastJuly 2025 Levels & Real-Time Chart Breakout Alerts - newser.com

Sep 29, 2025

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Spero Therapeutics Inc Stock (SPRO) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Keutzer Timothy
Chief Operating Officer
Aug 28 '25
Sale
1.97
1,695
3,339
739,744
Keutzer Timothy
Chief Operating Officer
Feb 05 '25
Sale
0.78
56,537
44,099
741,439
Rajavelu Esther
CFO & CBO
Feb 05 '25
Sale
0.78
20,689
16,137
724,720
Shukla Sath
CEO & President
Feb 05 '25
Sale
0.78
155,333
121,160
1,736,883
Mahadevia Ankit
Director
Feb 05 '25
Sale
0.78
69,219
53,991
689,866
Rajavelu Esther
CFO & CBO
Nov 07 '24
Sale
1.31
23,351
30,590
396,515
Rajavelu Esther
CFO & CBO
Nov 08 '24
Sale
1.30
17,245
22,418
379,270
$84.73
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biotechnology ONC
$327.03
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Cap:     |  Volume (24h):