2.37
price down icon1.66%   -0.04
after-market After Hours: 2.47 0.10 +4.22%
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Spero Therapeutics Inc stock is traded at $2.37, with a volume of 479.43K. It is down -1.66% in the last 24 hours and up +7.24% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. Besides, it is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.41
Open:
$2.39
24h Volume:
479.43K
Relative Volume:
1.62
Market Cap:
$133.52M
Revenue:
$29.32M
Net Income/Loss:
$-43.84M
P/E Ratio:
-2.9815
EPS:
-0.7949
Net Cash Flow:
$-27.67M
1W Performance:
-4.05%
1M Performance:
+7.24%
6M Performance:
+25.40%
1Y Performance:
+166.29%
1-Day Range:
Value
$2.34
$2.48
1-Week Range:
Value
$2.2901
$2.48
52-Week Range:
Value
$0.5052
$3.22

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
32
Name
Twitter
@spero_tx
Name
Next Earnings Date
2026-03-26
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO vs VRTX, REGN, ALNY, ARGX, INSM

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SPRO icon
SPRO
Spero Therapeutics Inc
2.37 135.78M 29.32M -43.84M -27.67M -0.7949
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
453.74 115.58B 12.07B 3.95B 3.19B 15.33
REGN icon
REGN
Regeneron Pharmaceuticals Inc
756.73 79.23B 14.34B 4.50B 3.77B 41.56
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
328.16 43.59B 3.71B 313.75M 465.38M 2.2571
ARGX icon
ARGX
Argen X Se Adr
692.83 43.26B 4.16B 1.29B 734.26M 19.58
INSM icon
INSM
Insmed Inc
147.60 31.97B 606.42M -1.28B -997.58M -6.403

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
04:42 AM

Spero Therapeutics earnings beat by $0.73, revenue topped estimates - Investing.com

04:42 AM
pulisher
04:37 AM

Spero Therapeutics shares jump over 4% on better-than-expected Q4 print - Investing.com Canada

04:37 AM
pulisher
04:25 AM

Spero Therapeutics Announces Fourth Quarter and Full Year 2025 Operating Results and Provides a Business Update - The Manila Times

04:25 AM
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04:22 AM

Spero Therapeutics Q4 revenue nearly triples, swings to profit - TradingView

04:22 AM
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04:15 AM

Spero Therapeutics 2025 10-K: $66.8M Revenue, $0.15 EPS - TradingView

04:15 AM
pulisher
04:10 AM

Spero Therapeutics (NASDAQ: SPRO) turns 2025 profit as tebipenem advances - Stock Titan

04:10 AM
pulisher
04:05 AM

[10-K] Spero Therapeutics, Inc. Fi... - Stock Titan

04:05 AM
pulisher
04:05 AM

Spero’s oral UTI antibiotic faces FDA decision on June 18 - Stock Titan

04:05 AM
pulisher
04:41 AM

Can Spero Therapeutics Inc sustain earnings growth2026 Macro Impact & Risk Adjusted Buy and Sell Alerts - baoquankhu1.vn

04:41 AM
pulisher
Mar 24, 2026

Down 17.7% in 4 Weeks, Here's Why Spero Therapeutics (SPRO) Looks Ripe for a Turnaround - MSN

Mar 24, 2026
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Mar 23, 2026

Analyst Calls: Is Spero Therapeutics Inc stock showing strong momentumWeekly Gains Summary & Fast Moving Stock Watchlists - baoquankhu1.vn

Mar 23, 2026
pulisher
Mar 21, 2026

Spero Therapeutics (NASDAQ:SPRO) Downgraded by Wall Street Zen to "Hold" - MarketBeat

Mar 21, 2026
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Mar 20, 2026

SPRO Stock Price, Quote & Chart | SPERO THERAPEUTICS INC (NASDAQ:SPRO) - ChartMill

Mar 20, 2026
pulisher
Mar 19, 2026

Activity Recap: Is Spero Therapeutics Inc stock showing strong momentumPortfolio Gains Summary & Fast Gain Stock Tips - baoquankhu1.vn

Mar 19, 2026
pulisher
Mar 19, 2026

Spero Therapeutics (SPRO) Expected to Announce Earnings on Thursday - MarketBeat

Mar 19, 2026
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Mar 18, 2026

Spero Therapeutics Inc 預計每股虧損 55 美分財報前瞻 - TradingView

Mar 18, 2026
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Mar 18, 2026

Spero Therapeutics to Report Fourth Quarter and Full Year 2025 Financial Results and Provide Business Update on March 26, 2026 - marketscreener.com

Mar 18, 2026
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Mar 18, 2026

Spero Therapeutics to post Q4 and 2025 results on March 26 - Stock Titan

Mar 18, 2026
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Mar 18, 2026

Spero Therapeutics to Report Fourth Quarter and Full Year - GlobeNewswire

Mar 18, 2026
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Mar 16, 2026

Weekly Earnings: What are Spero Therapeutics Incs recent SEC filings showingQuarterly Trade Report & Capital Efficient Trading Techniques - baoquankhu1.vn

Mar 16, 2026
pulisher
Mar 15, 2026

Spero Therapeutics, Inc. (NASDAQ:SPRO) Sees Large Decline in Short Interest - MarketBeat

Mar 15, 2026
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Mar 12, 2026

Profit Recap: Is Spero Therapeutics Inc stock showing strong momentumStop Loss & Weekly High Conviction Trade Ideas - baoquankhu1.vn

Mar 12, 2026
pulisher
Mar 12, 2026

Spero Therapeutics Inc erwartet einen Verlust von 55 Cents pro AktieEarnings Preview - TradingView

Mar 12, 2026
pulisher
Mar 10, 2026

Spero Therapeutics (NASDAQ:SPRO) Stock Price Passes Above 50-Day Moving AverageHere's What Happened - MarketBeat

Mar 10, 2026
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Mar 07, 2026

Dow Update: Can Spero Therapeutics Inc lead its sector in growth2025 Earnings Impact & Free High Return Stock Watch Alerts - baoquankhu1.vn

Mar 07, 2026
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Mar 07, 2026

Stock Recap: Can Spero Therapeutics Inc ride the EV waveMarket Movers & Daily Chart Pattern Signals - baoquankhu1.vn

Mar 07, 2026
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Mar 06, 2026

Big Picture: Will Spero Therapeutics Inc benefit from seasonalityWeekly Profit Summary & Weekly Market Pulse Alerts - baoquankhu1.vn

Mar 06, 2026
pulisher
Mar 04, 2026

SPRO SEC FilingsSpero Therapeuti 10-K, 10-Q, 8-K Forms - Stock Titan

Mar 04, 2026
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Mar 02, 2026

Short Interest in Spero Therapeutics, Inc. (NASDAQ:SPRO) Declines By 24.0% - MarketBeat

Mar 02, 2026
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Feb 27, 2026

SPRO Earning Date, Earning Analysis and Earning Prediction - Intellectia AI

Feb 27, 2026
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Feb 25, 2026

Spero Therapeutics (NASDAQ:SPRO) Shares Pass Above 200-Day Moving AverageShould You Sell? - MarketBeat

Feb 25, 2026
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Feb 21, 2026

Can Spero Therapeutics Inc. (2HA) stock sustain margin levels2025 Trading Recap & Fast Entry Momentum Trade Alerts - mfd.ru

Feb 21, 2026
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Feb 16, 2026

Aug PostEarnings: Can Spero Therapeutics Inc sustain earnings growth2025 Retail Activity & Low Drawdown Trading Strategies - baoquankhu1.vn

Feb 16, 2026
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Feb 14, 2026

Valuation Update: Is Spero Therapeutics Inc stock showing strong momentum2025 Market Overview & Daily Volume Surge Signals - baoquankhu1.vn

Feb 14, 2026
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Feb 14, 2026

Trade Alert: CEO, CFO Of Spero Therapeutics Esther Rajavelu Has Sold Stock - simplywall.st

Feb 14, 2026
pulisher
Feb 13, 2026

Is Spero Therapeutics Inc. a good stock for dollar cost averaging2025 Price Targets & Weekly High Potential Stock Alerts - mfd.ru

Feb 13, 2026
pulisher
Feb 11, 2026

Spero Therapeutics: Tebipenem’s FDA Path Supports A Speculative Buy (NASDAQ:SPRO) - Seeking Alpha

Feb 11, 2026
pulisher
Feb 09, 2026

Esther Rajavelu Sells 87,917 Shares of Spero Therapeutics (NASDAQ:SPRO) Stock - MarketBeat

Feb 09, 2026
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Feb 09, 2026

Keutzer, Spero Therapeutics COO, sells $44k in shares - Investing.com

Feb 09, 2026
pulisher
Feb 09, 2026

Spero Therapeutics CEO sells $207k in stock By Investing.com - Investing.com Canada

Feb 09, 2026
pulisher
Feb 09, 2026

Keutzer, Spero Therapeutics COO, sells $44k in shares By Investing.com - Investing.com Canada

Feb 09, 2026
pulisher
Feb 09, 2026

Spero Therapeutics CEO sells $207k in stock - Investing.com

Feb 09, 2026
pulisher
Feb 06, 2026

Aug Breakouts: What drives Spero Therapeutics Incs stock priceEarnings Summary Report & Safe Entry Zone Tips - baoquankhu1.vn

Feb 06, 2026
pulisher
Feb 05, 2026

Spero Therapeutics (NASDAQ:SPRO) Insider Sells 18,442 Shares - MarketBeat

Feb 05, 2026
pulisher
Feb 05, 2026

Spero Therapeutics (NASDAQ:SPRO) Stock Price Crosses Below 200 Day Moving AverageWhat's Next? - MarketBeat

Feb 05, 2026
pulisher
Feb 04, 2026

Spero therapeutics exec Rajavelu sells $40k in shares By Investing.com - Investing.com Australia

Feb 04, 2026
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Feb 04, 2026

Spero therapeutics exec Rajavelu sells $40k in shares - Investing.com

Feb 04, 2026
pulisher
Jan 31, 2026

Spero Therapeutics announces board resignation and SEC investigation closure By Investing.com - Investing.com South Africa

Jan 31, 2026
pulisher
Jan 30, 2026

Spero Therapeutics Co-Founder Resigns From Board Roles - TipRanks

Jan 30, 2026
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Jan 30, 2026

SEC ends Spero Therapeutics (NASDAQ: SPRO) probe as director steps down - Stock Titan

Jan 30, 2026
pulisher
Jan 30, 2026

SEC Enforcement Action Against Former Spero Executives: Individual Liability For Misleading FDA-Related Disclosures - marketscreener.com

Jan 30, 2026

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$27.35
price down icon 0.04%
$46.94
price down icon 0.19%
$53.57
price up icon 0.06%
$87.46
price down icon 1.48%
ONC ONC
$276.95
price down icon 2.29%
$147.60
price down icon 0.48%
Cap:     |  Volume (24h):