22.05
price down icon1.17%   -0.26
after-market After Hours: 22.05
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Apellis Pharmaceuticals Inc stock is traded at $22.05, with a volume of 1.34M. It is down -1.17% in the last 24 hours and down -4.96% over the past month. Apellis Pharmaceuticals Inc is a commercial-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system, which is an integral component of the immune system, at the level of C3, the central protein in the complement cascade.
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Previous Close:
$22.31
Open:
$22.23
24h Volume:
1.34M
Relative Volume:
0.47
Market Cap:
$2.79B
Revenue:
$715.22M
Net Income/Loss:
$-250.10M
P/E Ratio:
-10.86
EPS:
-2.03
Net Cash Flow:
$-205.58M
1W Performance:
-2.26%
1M Performance:
-4.96%
6M Performance:
-7.74%
1Y Performance:
-22.66%
1-Day Range:
Value
$21.72
$22.38
1-Week Range:
Value
$21.71
$23.69
52-Week Range:
Value
$16.10
$30.48

Apellis Pharmaceuticals Inc Stock (APLS) Company Profile

Name
Name
Apellis Pharmaceuticals Inc
Name
Phone
617-977-5700
Name
Address
100 FIFTH AVENUE, WALTHAM, KY
Name
Employee
710
Name
Twitter
@ApellisPharma
Name
Next Earnings Date
2024-12-05
Name
Latest SEC Filings
Name
APLS's Discussions on Twitter

Compare APLS vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
APLS
Apellis Pharmaceuticals Inc
22.05 2.82B 715.22M -250.10M -205.58M -2.03
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
465.02 117.03B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
783.65 82.35B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
833.54 51.64B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
308.48 42.58B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
346.42 38.87B 4.98B 69.60M 525.67M 0.5198

Apellis Pharmaceuticals Inc Stock (APLS) Upgrades & Downgrades

Date Action Analyst Rating Change
Jan-28-26 Initiated Barclays Equal Weight
Jan-21-26 Upgrade BofA Securities Neutral → Buy
Nov-06-25 Initiated Wolfe Research Peer Perform
Oct-15-25 Initiated Wells Fargo Overweight
Sep-26-25 Downgrade Goldman Neutral → Sell
May-09-25 Downgrade BofA Securities Buy → Neutral
May-09-25 Downgrade Raymond James Strong Buy → Outperform
Apr-29-25 Initiated Cantor Fitzgerald Overweight
Dec-17-24 Downgrade Goldman Buy → Neutral
Nov-21-24 Initiated Morgan Stanley Equal-Weight
Oct-25-24 Initiated RBC Capital Mkts Sector Perform
Oct-16-24 Initiated Scotiabank Sector Outperform
Oct-16-24 Initiated William Blair Outperform
May-31-24 Initiated Piper Sandler Neutral
Feb-05-24 Upgrade Jefferies Hold → Buy
Dec-14-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-09-23 Initiated Goldman Buy
Nov-02-23 Initiated Mizuho Neutral
Oct-06-23 Upgrade JP Morgan Neutral → Overweight
Sep-15-23 Upgrade Wells Fargo Equal Weight → Overweight
Aug-29-23 Reiterated Citigroup Buy
Aug-03-23 Downgrade JP Morgan Overweight → Neutral
Aug-01-23 Downgrade BofA Securities Buy → Neutral
Jan-03-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-10-22 Downgrade Jefferies Buy → Hold
Jul-19-22 Initiated H.C. Wainwright Buy
Jun-17-22 Resumed Stifel Buy
Apr-14-22 Downgrade ROTH Capital Neutral → Sell
Dec-08-21 Initiated Wells Fargo Overweight
Nov-29-21 Downgrade ROTH Capital Buy → Neutral
Sep-10-21 Reiterated BMO Capital Markets Outperform
Sep-10-21 Reiterated Credit Suisse Neutral
Sep-10-21 Reiterated Needham Buy
Sep-10-21 Reiterated Oppenheimer Outperform
Sep-10-21 Downgrade Wedbush Outperform → Neutral
Aug-19-21 Initiated Jefferies Buy
Aug-19-21 Upgrade Wedbush Neutral → Outperform
May-21-21 Initiated UBS Buy
Apr-16-21 Initiated Goldman Buy
Nov-19-20 Initiated Needham Buy
Sep-01-20 Initiated Stifel Buy
Jul-20-20 Initiated ROTH Capital Buy
Jun-17-20 Initiated BTIG Research Neutral
Apr-01-20 Initiated Raymond James Strong Buy
Mar-31-20 Initiated BMO Capital Markets Outperform
Mar-11-20 Upgrade Wedbush Underperform → Neutral
Jan-07-20 Initiated SVB Leerink Mkt Perform
Dec-19-19 Initiated BofA/Merrill Buy
Nov-22-19 Initiated Wedbush Underperform
Nov-05-19 Initiated Credit Suisse Neutral
Aug-01-19 Reiterated Cantor Fitzgerald Overweight
Jul-12-19 Upgrade JP Morgan Neutral → Overweight
Mar-29-19 Initiated Robert W. Baird Outperform
Jan-23-19 Downgrade JP Morgan Overweight → Neutral
Jul-30-18 Upgrade B. Riley FBR Neutral → Buy
May-24-18 Initiated Cantor Fitzgerald Overweight
Apr-12-18 Downgrade B. Riley FBR, Inc. Buy → Neutral
Feb-08-18 Initiated B. Riley FBR, Inc. Buy
View All

Apellis Pharmaceuticals Inc Stock (APLS) Latest News

pulisher
Feb 11, 2026

(APLS) Risk Channels and Responsive Allocation - Stock Traders Daily

Feb 11, 2026
pulisher
Feb 11, 2026

Apellis Pharmaceuticals (APLS) Valuation Check After Recent S&P 1000 Index Inclusion - Yahoo Finance

Feb 11, 2026
pulisher
Feb 11, 2026

Apellis Pharmaceuticals, Inc. $APLS Shares Sold by Savant Capital LLC - MarketBeat

Feb 11, 2026
pulisher
Feb 11, 2026

ING Groep NV Acquires 866,200 Shares of Apellis Pharmaceuticals, Inc. $APLS - MarketBeat

Feb 11, 2026
pulisher
Feb 10, 2026

Apellis Pharmaceuticals to Host Conference Call on February 24, 2026, to Discuss Fourth Quarter and Full Year 2025 Financial Results - The Manila Times

Feb 10, 2026
pulisher
Feb 08, 2026

Market Overview: Will Apellis Pharmaceuticals Inc outperform the market in YEARWeekly Trade Recap & Free Risk Controlled Daily Trade Plans - baoquankhu1.vn

Feb 08, 2026
pulisher
Feb 07, 2026

Broad S&P Index Inclusion Might Change The Case For Investing In Apellis Pharmaceuticals (APLS) - simplywall.st

Feb 07, 2026
pulisher
Feb 05, 2026

A Look At Apellis Pharmaceuticals (APLS) Valuation After Recent S&P Index Additions - Sahm

Feb 05, 2026
pulisher
Feb 03, 2026

5 Drug/Biotech Stocks Likely to Outperform Q4 Earnings Estimates - TradingView

Feb 03, 2026
pulisher
Feb 01, 2026

How Empaveli’s Rapid Uptake and Q4 2025 Revenue Momentum Will Impact Apellis Pharmaceuticals (APLS) Investors - Sahm

Feb 01, 2026
pulisher
Jan 31, 2026

(APLS) Movement as an Input in Quant Signal Sets - Stock Traders Daily

Jan 31, 2026
pulisher
Jan 30, 2026

BofA Upgrades Apellis (APLS) to Buy Citing Rapid Empaveli Adoption and Underappreciated Kidney Disease Market Potential - Finviz

Jan 30, 2026
pulisher
Jan 29, 2026

Will Apellis Pharmaceuticals Inc. benefit from geopolitical trendsShort Setup & Reliable Intraday Trade Alerts - mfd.ru

Jan 29, 2026
pulisher
Jan 29, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Upgraded to Hold at Barclays - MarketBeat

Jan 29, 2026
pulisher
Jan 29, 2026

Apellis Pharmaceuticals (APLS) Surges 5.8%: Is This an Indication of Further Gains? - Yahoo Finance

Jan 29, 2026
pulisher
Jan 29, 2026

J. Safra Sarasin Holding AG Sells 45,184 Shares of Apellis Pharmaceuticals, Inc. $APLS - MarketBeat

Jan 29, 2026
pulisher
Jan 28, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Stock Price Up 7.5%Still a Buy? - MarketBeat

Jan 28, 2026
pulisher
Jan 28, 2026

Apellis Pharmaceuticals (APLS) Receives Equal-Weight Rating from Barclays | APLS Stock News - GuruFocus

Jan 28, 2026
pulisher
Jan 28, 2026

This Oklo Analyst Begins Coverage On A Bullish Note; Here Are Top 4 Initiations For Wednesday - Benzinga

Jan 28, 2026
pulisher
Jan 28, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Coverage Initiated at Barclays - MarketBeat

Jan 28, 2026
pulisher
Jan 28, 2026

Apellis Pharmaceuticals, Inc. (APLS) Stock Analysis: Exploring A 56.89% Upside Potential - DirectorsTalk Interviews

Jan 28, 2026
pulisher
Jan 28, 2026

TTM Technologies, Dutch Bros to join S&P 400 Index; Amneal, Apellis to be part of S&P SmallCap 600 (CIVI:NYSE) - Seeking Alpha

Jan 28, 2026
pulisher
Jan 27, 2026

TTM Technologies, Dutch Bros, Advanced Energy Industries, and American Healthcare REIT Set to Join S&P MidCap 400; Others to Join S&P SmallCap 600 - Benzinga

Jan 27, 2026
pulisher
Jan 27, 2026

Analysts Offer Insights on Healthcare Companies: Apellis Pharmaceuticals (APLS), Ascendis Pharma (ASND) and Abivax SA Sponsored ADR (ABVX) - The Globe and Mail

Jan 27, 2026
pulisher
Jan 27, 2026

A Look At Apellis Pharmaceuticals (APLS) Valuation As GAAP Profitability And Syfovre Commercialization Gain Traction - Yahoo Finance

Jan 27, 2026
pulisher
Jan 27, 2026

Apellis Turns GAAP Profitable As Syfovre Sales Shift Story To Execution - Sahm

Jan 27, 2026
pulisher
Jan 27, 2026

Apellis Pharmaceuticals, Inc. $APLS Shares Bought by EFG Asset Management North America Corp. - MarketBeat

Jan 27, 2026
pulisher
Jan 26, 2026

Value Recap: Is BAFN a strong growth stockGap Up & Reliable Breakout Stock Forecasts - baoquankhu1.vn

Jan 26, 2026
pulisher
Jan 26, 2026

Buybacks Report: Will Apellis Pharmaceuticals Inc. benefit from geopolitical trendsQuarterly Portfolio Summary & High Accuracy Swing Trade Signals - baoquankhu1.vn

Jan 26, 2026
pulisher
Jan 25, 2026

Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) Receives Average Recommendation of "Moderate Buy" from Brokerages - MarketBeat

Jan 25, 2026
pulisher
Jan 25, 2026

Apellis upgraded at BofA on launch trajectory for kidney disease therapy - MSN

Jan 25, 2026
pulisher
Jan 24, 2026

Apellis, Olema, Exicure, Immunovant, LivePerson Insider Shake-Up - TipRanks

Jan 24, 2026
pulisher
Jan 24, 2026

Apellis Pharma CEO Francois sells $592k in shares By Investing.com - Investing.com Canada

Jan 24, 2026
pulisher
Jan 23, 2026

Caroline Baumal Sells 2,797 Shares of Apellis Pharmaceuticals (NASDAQ:APLS) Stock - MarketBeat

Jan 23, 2026
pulisher
Jan 23, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) General Counsel David Watson Sells 7,832 Shares - MarketBeat

Jan 23, 2026
pulisher
Jan 23, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) CAO Sells 2,064 Shares of Stock - MarketBeat

Jan 23, 2026
pulisher
Jan 23, 2026

Timothy Eugene Sullivan Sells 10,287 Shares of Apellis Pharmaceuticals (NASDAQ:APLS) Stock - MarketBeat

Jan 23, 2026
pulisher
Jan 23, 2026

Apellis stock surges after Sobi $300 million royalty deal - MSN

Jan 23, 2026
pulisher
Jan 23, 2026

Aug Retail: Does Apellis Pharmaceuticals Inc stock have upside surprise potentialSell Signal & Real-Time Chart Pattern Alerts - baoquankhu1.vn

Jan 23, 2026
pulisher
Jan 22, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Fits the 'Affordable Growth' Investment Strategy - ChartMill

Jan 22, 2026
pulisher
Jan 22, 2026

Nicholson nur, Apellis Pharmaceuticals CTO, sells $43k in APLS stock - Investing.com Nigeria

Jan 22, 2026
pulisher
Jan 22, 2026

Apellis Pharma CMO Baumal sells $37k in shares By Investing.com - Investing.com India

Jan 22, 2026
pulisher
Jan 22, 2026

Nicholson nur, Apellis Pharmaceuticals CTO, sells $43k in APLS stock By Investing.com - Investing.com South Africa

Jan 22, 2026
pulisher
Jan 22, 2026

Apellis Pharma VP Chopas sells $14k in shares By Investing.com - Investing.com Canada

Jan 22, 2026
pulisher
Jan 21, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) CEO Sells 8,182 Shares of Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Insider Sells $26,399.86 in Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) Insider Sells 909 Shares of Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) Insider Sells 1,882 Shares of Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) General Counsel Sells 2,475 Shares of Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Insider Selling: Apellis Pharmaceuticals (NASDAQ:APLS) CFO Sells 2,892 Shares of Stock - MarketBeat

Jan 21, 2026
pulisher
Jan 21, 2026

Apellis Pharmaceuticals' Empaveli Approved, Projected $508 Million Sales by 2033 - Intellectia AI

Jan 21, 2026

Apellis Pharmaceuticals Inc Stock (APLS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$44.80
price up icon 1.24%
$26.75
price down icon 0.19%
$100.75
price up icon 1.93%
$105.76
price down icon 3.31%
$146.17
price down icon 1.52%
biotechnology ONC
$346.42
price down icon 1.38%
Cap:     |  Volume (24h):