8.94
price up icon21.30%   1.57
after-market After Hours: 9.13 0.19 +2.13%
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Karyopharm Therapeutics Inc stock is traded at $8.94, with a volume of 2.75M. It is up +21.30% in the last 24 hours and up +9.09% over the past month. Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company pioneering novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. XPOVIO (selinexor), is approved in the U.S. in multiple hematologic malignancy indications, including in combination with Velcade (bortezomib) and dexamethasone for the treatment of adult patients with multiple myeloma after at least one prior therapy, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma and as a monotherapy for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company derives its revenue from United States.
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Previous Close:
$7.37
Open:
$6.72
24h Volume:
2.75M
Relative Volume:
8.26
Market Cap:
$163.69M
Revenue:
$137.27M
Net Income/Loss:
$-123.57M
P/E Ratio:
-0.8115
EPS:
-11.016
Net Cash Flow:
$-102.89M
1W Performance:
+46.80%
1M Performance:
+9.09%
6M Performance:
+122.39%
1Y Performance:
+1.74%
1-Day Range:
Value
$6.72
$9.9399
1-Week Range:
Value
$5.90
$9.9399
52-Week Range:
Value
$3.51
$10.38

Karyopharm Therapeutics Inc Stock (KPTI) Company Profile

Name
Name
Karyopharm Therapeutics Inc
Name
Phone
617-658-0600
Name
Address
85 WELLS AVENUE, NEWTON, MA
Name
Employee
279
Name
Twitter
@Karyopharm
Name
Next Earnings Date
2024-11-05
Name
Latest SEC Filings
Name
KPTI's Discussions on Twitter

Compare KPTI vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
KPTI
Karyopharm Therapeutics Inc
8.94 134.95M 137.27M -123.57M -102.89M -11.02
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
465.02 117.03B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
783.65 82.35B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
833.54 51.64B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
308.48 42.58B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
346.42 38.87B 4.98B 69.60M 525.67M 0.5198

Karyopharm Therapeutics Inc Stock (KPTI) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-05-26 Initiated Cantor Fitzgerald Overweight
Oct-13-25 Upgrade H.C. Wainwright Neutral → Buy
Jul-16-25 Downgrade H.C. Wainwright Buy → Neutral
Jul-11-25 Resumed H.C. Wainwright Buy
Jan-19-23 Initiated Piper Sandler Overweight
Nov-04-22 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-09-22 Upgrade JP Morgan Underweight → Neutral
Nov-19-21 Resumed Morgan Stanley Equal-Weight
Aug-06-21 Downgrade JP Morgan Overweight → Neutral
Aug-06-21 Downgrade RBC Capital Mkts Outperform → Sector Perform
Aug-06-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-02-20 Initiated Morgan Stanley Overweight
Mar-04-20 Initiated Barclays Overweight
Jan-17-20 Downgrade Wedbush Outperform → Neutral
Jul-23-19 Upgrade JP Morgan Neutral → Overweight
Jul-05-19 Reiterated H.C. Wainwright Buy
Jul-05-19 Reiterated Robert W. Baird Outperform
Mar-01-19 Downgrade JP Morgan Overweight → Neutral
Feb-28-19 Reiterated BofA/Merrill Underperform
Feb-27-19 Downgrade BofA/Merrill Neutral → Underperform
Jan-03-19 Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18 Initiated B. Riley FBR Buy
Nov-09-18 Upgrade Wedbush Neutral → Outperform
May-24-18 Downgrade Wedbush Outperform → Neutral
Apr-02-18 Resumed Leerink Partners Outperform
Nov-15-17 Resumed H.C. Wainwright Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Sep-08-16 Reiterated H.C. Wainwright Buy
Aug-30-16 Upgrade Jefferies Hold → Buy
Aug-18-16 Initiated H.C. Wainwright Buy
Jun-28-16 Initiated Robert W. Baird Outperform
View All

Karyopharm Therapeutics Inc Stock (KPTI) Latest News

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05:20 AM

Karyopharm Therapeutics Inc Shares Rise After Q4 2025 Results - AlphaStreet News

05:20 AM
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03:48 AM

Karyopharm Therapeutics Inc (KPTI) Q4 2025 Earnings Call Highlights: Revenue Growth Amidst Financial Challenges - GuruFocus

03:48 AM
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02:48 AM

Karyopharm reports fourth quarter and full year 2025 financial results and highlights recent company progress - marketscreener.com

02:48 AM
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02:37 AM

Karyopharm Q4 2025 slides: Revenue growth amid pivotal myelofibrosis readout preparations - Investing.com

02:37 AM
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02:12 AM

Karyopharm Therapeutics Inc (KPTI) Q4 2025 Earnings Call Highlig - GuruFocus

02:12 AM
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01:22 AM

Karyopharm Therapeutics (NASDAQ:KPTI) Announces Earnings Results, Misses Expectations By $3.45 EPS - MarketBeat

01:22 AM
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01:13 AM

Page not foundAirwhon - MarketBeat

01:13 AM
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10:02 AM

Earnings call transcript: Karyopharm sees 11.8% revenue rise in Q4 2025 - Investing.com India

10:02 AM
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09:51 AM

Karyopharm Q4 2025 slides: Revenue growth amid pivotal myelofibrosis readout preparations By Investing.com - Investing.com India

09:51 AM
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09:39 AM

KPTI: Q4 revenue up, operating loss improved, pivotal phase 3 data in myelofibrosis due soon - TradingView

09:39 AM
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09:07 AM

Karyopharm Therapeutics: Fourth Quarter Earnings Overview - Bitget

09:07 AM
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08:45 AM

Karyopharm Therapeutics (KPTI) Reports Q4 Loss, Tops Revenue Estimates - Yahoo Finance

08:45 AM
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08:36 AM

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Receives Average Rating of "Moderate Buy" from Analysts - MarketBeat

08:36 AM
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08:31 AM

Karyopharm Therapeutics Inc (NASDAQ:KPTI) Reports Q4 Revenue Miss and Wider Loss, Stock Falls in Pre-Market - ChartMill

08:31 AM
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07:55 AM

KARYOPHARM THERAPEUTICS ($KPTI) Releases Q4 2025 Earnings - Quiver Quantitative

07:55 AM
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07:53 AM

Karyopharm Therapeutics: Q4 Earnings Snapshot - wwltv.com

07:53 AM
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07:30 AM

Karyopharm Reports Fourth Quarter and Full Year 2025 Financial Results and Highlights Recent Company Progress - PR Newswire

07:30 AM
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Feb 11, 2026

Karyopharm Reports 2025 Financials and 2026 Outlook - Intellectia AI

Feb 11, 2026
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Feb 11, 2026

Uncovering Potential: Karyopharm Therapeutics's Earnings Preview - Benzinga

Feb 11, 2026
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Feb 09, 2026

Investment Report: Can Karyopharm Therapeutics Inc disrupt its industry2025 Earnings Surprises & Low Risk High Reward Ideas - baoquankhu1.vn

Feb 09, 2026
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Feb 09, 2026

Stock Market Recap: Can Karyopharm Therapeutics Inc disrupt its industryTrade Performance Summary & Risk Managed Investment Entry Signals - baoquankhu1.vn

Feb 09, 2026
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Feb 07, 2026

Karyopharm Therapeutics (KPTI) Expected to Announce Earnings on Thursday - MarketBeat

Feb 07, 2026
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Feb 06, 2026

Karyopharm Therapeutics (KPRX): Tiny Cancer Stock, Massive Drama – Is It Worth Your Money? - AD HOC NEWS

Feb 06, 2026
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Feb 05, 2026

Cantor Fitzgerald Initiates Coverage on KPTI with Overweight Rat - GuruFocus

Feb 05, 2026
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Feb 05, 2026

Cantor Fitzgerald initiates Karyopharm stock with Overweight rating By Investing.com - Investing.com South Africa

Feb 05, 2026
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Feb 05, 2026

Karyopharm to Report Fourth Quarter and Full Year 2025 Financial Results on February 12, 2026 - Karyopharm

Feb 05, 2026
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Feb 05, 2026

Cancer drug maker Karyopharm to detail 2025 results in Feb. 12 call - Stock Titan

Feb 05, 2026
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Feb 05, 2026

Cantor Fitzgerald Initiates Coverage on Karyopharm Therapeutics (NASDAQ:KPTI) - MarketBeat

Feb 05, 2026
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Feb 05, 2026

Cantor Fitzgerald initiates Karyopharm stock with Overweight rating - Investing.com India

Feb 05, 2026
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Feb 02, 2026

Karyopharm Therapeutics reports inducement grants under Nasdaq Listing Rule - marketscreener.com

Feb 02, 2026
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Feb 02, 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule - TradingView

Feb 02, 2026
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Feb 02, 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) - 富途牛牛

Feb 02, 2026
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Feb 01, 2026

FOMO Trade: How sensitive is Karyopharm Therapeutics Inc to inflationJuly 2025 Highlights & High Accuracy Investment Signals - baoquankhu1.vn

Feb 01, 2026
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Feb 01, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Short Interest Up 110.2% in January - Defense World

Feb 01, 2026
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Jan 30, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Short Interest Update - MarketBeat

Jan 30, 2026
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Jan 30, 2026

Abate, Karyopharm Therapeutics CAO, sells $351 in stock By Investing.com - Investing.com UK

Jan 30, 2026
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Jan 29, 2026

Abate, Karyopharm Therapeutics CAO, sells $351 in stock - Investing.com

Jan 29, 2026
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Jan 29, 2026

Myelofibrosis Clinical Trials Outlook: Competitive Intelligence, Regulatory Progress, Emerging Therapies, Mechanisms of Action, and Administration Pathways – DelveInsight - Barchart.com

Jan 29, 2026
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Jan 27, 2026

Portfolio Update: mơ công an bắt xeQuarterly Earnings Report & Proven Capital Preservation Methods - baoquankhu1.vn

Jan 27, 2026
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Jan 27, 2026

Karyopharm Therapeutics (NASDAQ:KPTI) Shares Pass Below 50-Day Moving AverageHere's What Happened - MarketBeat

Jan 27, 2026
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Jan 26, 2026

Can Karyopharm Unlock Xpovio's Growth In 2026 With Pivotal Myelofibrosis Data Ahead? - RTTNews

Jan 26, 2026
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Jan 23, 2026

How New Price Targets Are Shaping The Story For Karyopharm Therapeutics (KPTI) - Yahoo Finance

Jan 23, 2026
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Jan 23, 2026

Abate, Karyopharm Therapeutics CAO, sells $1.6k in stock By Investing.com - Investing.com UK

Jan 23, 2026
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Jan 23, 2026

Abate, Karyopharm Therapeutics CAO, sells $1.6k in stock - Investing.com

Jan 23, 2026
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Jan 20, 2026

RBC Raises Price Target on Karyopharm Therapeutics to $23 From $19, Keeps Outperform Rating - marketscreener.com

Jan 20, 2026
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Jan 18, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Receives Consensus Recommendation of "Moderate Buy" from Brokerages - MarketBeat

Jan 18, 2026
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Jan 18, 2026

Aug Spikes: Can Karyopharm Therapeutics Inc disrupt its industryDividend Hike & Verified Entry Point Signals - baoquankhu1.vn

Jan 18, 2026
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Jan 16, 2026

Chart Watch: Will Karyopharm Therapeutics Inc outperform its industry peersJuly 2025 Intraday Action & Technical Pattern Alert System - baoquankhu1.vn

Jan 16, 2026
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Jan 13, 2026

Options Flow: Will Karyopharm Therapeutics Inc 25K0 stock rise with strong economyWeekly Risk Summary & Safe Entry Zone Tips - Bộ Nội Vụ

Jan 13, 2026
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Jan 13, 2026

Layoff Watch: What margin trends mean for Karyopharm Therapeutics Inc stockWeekly Stock Analysis & Accurate Intraday Trading Signals - Bộ Nội Vụ

Jan 13, 2026
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Jan 13, 2026

Analysts Are Bullish on Top Healthcare Stocks: Karyopharm Therapeutics (KPTI), Establishment Labs Holdings (ESTA) - The Globe and Mail

Jan 13, 2026

Karyopharm Therapeutics Inc Stock (KPTI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$44.80
price up icon 1.24%
$26.75
price down icon 0.19%
$100.75
price up icon 1.93%
$105.76
price down icon 3.31%
$146.17
price down icon 1.52%
biotechnology ONC
$346.42
price down icon 1.38%
Cap:     |  Volume (24h):