9.02
price down icon4.14%   -0.39
after-market After Hours: 9.02
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Karyopharm Therapeutics Inc stock is traded at $9.02, with a volume of 180.40K. It is down -4.14% in the last 24 hours and up +42.72% over the past month. Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
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Previous Close:
$9.41
Open:
$9.61
24h Volume:
180.40K
Relative Volume:
0.19
Market Cap:
$203.41M
Revenue:
$146.07M
Net Income/Loss:
$-196.04M
P/E Ratio:
-0.5427
EPS:
-16.621
Net Cash Flow:
$-75.37M
1W Performance:
+7.38%
1M Performance:
+42.72%
6M Performance:
+72.80%
1Y Performance:
+43.86%
1-Day Range:
Value
$9.02
$9.61
1-Week Range:
Value
$8.1728
$9.61
52-Week Range:
Value
$3.6503
$10.99

Karyopharm Therapeutics Inc Stock (KPTI) Company Profile

Name
Name
Karyopharm Therapeutics Inc
Name
Phone
617-658-0600
Name
Address
85 WELLS AVENUE, NEWTON, MA
Name
Employee
228
Name
Twitter
@Karyopharm
Name
Next Earnings Date
2026-05-11
Name
Latest SEC Filings
Name
KPTI's Discussions on Twitter

Compare KPTI vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
KPTI icon
KPTI
Karyopharm Therapeutics Inc
9.02 212.21M 146.07M -196.04M -75.37M -16.62
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
427.65 107.87B 12.32B 4.34B 3.19B 16.86
REGN icon
REGN
Regeneron Pharmaceuticals Inc
721.05 73.63B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
807.55 49.42B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
303.00 40.20B 3.71B 313.75M 465.38M 2.2571
ONC icon
ONC
Beone Medicines Ltd Adr
313.32 33.06B 5.36B 287.73M 924.18M 2.5229

Karyopharm Therapeutics Inc Stock (KPTI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-10-26 Initiated Rodman & Renshaw Buy
Feb-05-26 Initiated Cantor Fitzgerald Overweight
Oct-13-25 Upgrade H.C. Wainwright Neutral → Buy
Jul-16-25 Downgrade H.C. Wainwright Buy → Neutral
Jul-11-25 Resumed H.C. Wainwright Buy
Jan-19-23 Initiated Piper Sandler Overweight
Nov-04-22 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-09-22 Upgrade JP Morgan Underweight → Neutral
Nov-19-21 Resumed Morgan Stanley Equal-Weight
Aug-06-21 Downgrade JP Morgan Overweight → Neutral
Aug-06-21 Downgrade RBC Capital Mkts Outperform → Sector Perform
Aug-06-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-02-20 Initiated Morgan Stanley Overweight
Mar-04-20 Initiated Barclays Overweight
Jan-17-20 Downgrade Wedbush Outperform → Neutral
Jul-23-19 Upgrade JP Morgan Neutral → Overweight
Jul-05-19 Reiterated H.C. Wainwright Buy
Jul-05-19 Reiterated Robert W. Baird Outperform
Mar-01-19 Downgrade JP Morgan Overweight → Neutral
Feb-28-19 Reiterated BofA/Merrill Underperform
Feb-27-19 Downgrade BofA/Merrill Neutral → Underperform
Jan-03-19 Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18 Initiated B. Riley FBR Buy
Nov-09-18 Upgrade Wedbush Neutral → Outperform
May-24-18 Downgrade Wedbush Outperform → Neutral
Apr-02-18 Resumed Leerink Partners Outperform
Nov-15-17 Resumed H.C. Wainwright Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Sep-08-16 Reiterated H.C. Wainwright Buy
Aug-30-16 Upgrade Jefferies Hold → Buy
Aug-18-16 Initiated H.C. Wainwright Buy
Jun-28-16 Initiated Robert W. Baird Outperform
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Karyopharm Therapeutics Inc Stock (KPTI) Latest News

pulisher
10:50 AM

Karyopharm Therapeutics (KPTI) price target increased by 13.33% to 13.87 - MSN

10:50 AM
pulisher
May 04, 2026

Karyopharm (NASDAQ: KPTI) registers resale of 8.843M shares from private placement - Stock Titan

May 04, 2026
pulisher
May 04, 2026

Karyopharm Therapeutics: Selling stockholder may resell up to 8,843,036 shares of Karyopharm common stockSEC filing - marketscreener.com

May 04, 2026
pulisher
May 04, 2026

Karyopharm Therapeutics: Selling Stockholder May Resell Up To 8,843,036 Shares Of Karyopharm Common StockSEC Filing - TradingView

May 04, 2026
pulisher
May 04, 2026

Karyopharm Therapeutics may offer up to $400 million in securitiesSEC filing - marketscreener.com

May 04, 2026
pulisher
May 04, 2026

Karyopharm Therapeutics (NASDAQ: KPTI) files $400M shelf, $100M ATM with Jefferies - Stock Titan

May 04, 2026
pulisher
May 04, 2026

Karyopharm (KPTI) Q1 2025 Earnings Transcript - AOL.com

May 04, 2026
pulisher
Apr 29, 2026

Karyopharm to seek label expansion for Xpovio in myelofibrosis after late-stage trial win - MSN

Apr 29, 2026
pulisher
Apr 29, 2026

KPTI stock down on mixed phase III myelofibrosis combo study data - MSN

Apr 29, 2026
pulisher
Apr 29, 2026

KPTI stock slumps pre-market even as Karyopharm’s myelofibrosis treatment meets primary endpoint — retail doubtful about FDA approval - MSN

Apr 29, 2026
pulisher
Apr 28, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Receives Consensus Rating of "Moderate Buy" from Analysts - MarketBeat

Apr 28, 2026
pulisher
Apr 27, 2026

Piper Sandler Reiterates Overweight Rating for Karyopharm Therapeutics (NASDAQ:KPTI) - MarketBeat

Apr 27, 2026
pulisher
Apr 27, 2026

KPTI Upgraded by Piper Sandler -- Price Target Raised to $16.00 - GuruFocus

Apr 27, 2026
pulisher
Apr 27, 2026

Piper Sandler Maintains Karyopharm Therapeutics(KPTI.US) With Buy Rating, Raises Target Price to $16 - Moomoo

Apr 27, 2026
pulisher
Apr 26, 2026

Karyopharm Therapeutics jumps 18%, raises $30M privately - MSN

Apr 26, 2026
pulisher
Apr 24, 2026

Karyopharm Therapeutics (KPTI) price target decreased by 22.08% to 12.24 - MSN

Apr 24, 2026
pulisher
Apr 22, 2026

Is Karyopharm Therapeutics (KPTI) stock considered a safe play | Q4 2025: Below ExpectationsPricing Power - Cổng thông tin điện tử tỉnh Lào Cai

Apr 22, 2026
pulisher
Apr 22, 2026

Karyopharm (KPTI) CMO logs pre-planned tax-related sale of 449 shares - Stock Titan

Apr 22, 2026
pulisher
Apr 21, 2026

Karyopharm’s myelofibrosis trial selected for ASCO presentation By Investing.com - Investing.com Australia

Apr 21, 2026
pulisher
Apr 21, 2026

Karyopharm’s myelofibrosis trial selected for ASCO presentation - Investing.com

Apr 21, 2026
pulisher
Apr 21, 2026

Karyopharm's Phase 3 SENTRY Trial in Myelofibrosis Selected for Late-Breaking Oral Presentation at ASCO 2026 Annual Meeting - Karyopharm

Apr 21, 2026
pulisher
Apr 21, 2026

Karyopharm Therapeutics (NASDAQ:KPTI) Share Price Passes Above 50 Day Moving AverageWhat's Next? - MarketBeat

Apr 21, 2026
pulisher
Apr 20, 2026

Is Karyopharm Therapeutics (KPTI) stock a smart investment today (Bullish Sentiment) 2026-04-20Risk Reward Ratio - Cổng thông tin điện tử tỉnh Lào Cai

Apr 20, 2026
pulisher
Apr 17, 2026

RBC Flags Seasonal Pressures Impacting Karyopharm Therapeutics Inc. (KPTI) Short-Term Performance - Insider Monkey

Apr 17, 2026
pulisher
Apr 16, 2026

KPTI SEC FilingsKaryopharm Therapeutics Inc 10-K, 10-Q, 8-K Forms - Stock Titan

Apr 16, 2026
pulisher
Apr 16, 2026

Karyopharm Therapeutics : Corporate Presentation - marketscreener.com

Apr 16, 2026

Karyopharm Therapeutics Inc Stock (KPTI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$28.82
price up icon 1.77%
$50.72
price up icon 0.56%
$95.26
price down icon 0.25%
$137.09
price down icon 1.69%
$151.07
price up icon 2.62%
ONC ONC
$313.32
price up icon 5.32%
Cap:     |  Volume (24h):