9.64
price up icon1.47%   0.14
pre-market  Pre-market:  9.61   -0.03   -0.31%
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Karyopharm Therapeutics Inc stock is traded at $9.64, with a volume of 172.43K. It is up +1.47% in the last 24 hours and up +25.68% over the past month. Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
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Previous Close:
$9.50
Open:
$9.65
24h Volume:
172.43K
Relative Volume:
0.20
Market Cap:
$218.47M
Revenue:
$146.07M
Net Income/Loss:
$-196.04M
P/E Ratio:
-0.58
EPS:
-16.621
Net Cash Flow:
$-75.37M
1W Performance:
+13.41%
1M Performance:
+25.68%
6M Performance:
+43.67%
1Y Performance:
+119.59%
1-Day Range:
Value
$9.365
$9.795
1-Week Range:
Value
$8.43
$10.22
52-Week Range:
Value
$3.6503
$10.99

Karyopharm Therapeutics Inc Stock (KPTI) Company Profile

Name
Name
Karyopharm Therapeutics Inc
Name
Phone
617-658-0600
Name
Address
85 WELLS AVENUE, NEWTON, MA
Name
Employee
228
Name
Twitter
@Karyopharm
Name
Next Earnings Date
2026-05-14
Name
Latest SEC Filings
Name
KPTI's Discussions on Twitter

Compare KPTI vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
KPTI icon
KPTI
Karyopharm Therapeutics Inc
9.64 218.47M 146.07M -196.04M -75.37M -16.62
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
450.46 114.33B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
614.98 64.47B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
884.20 54.99B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
287.80 38.42B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
160.06 34.03B 742.00K -1.37B -1.07B -7.0731

Karyopharm Therapeutics Inc Stock (KPTI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-10-26 Initiated Rodman & Renshaw Buy
Feb-05-26 Initiated Cantor Fitzgerald Overweight
Oct-13-25 Upgrade H.C. Wainwright Neutral → Buy
Jul-16-25 Downgrade H.C. Wainwright Buy → Neutral
Jul-11-25 Resumed H.C. Wainwright Buy
Jan-19-23 Initiated Piper Sandler Overweight
Nov-04-22 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-09-22 Upgrade JP Morgan Underweight → Neutral
Nov-19-21 Resumed Morgan Stanley Equal-Weight
Aug-06-21 Downgrade JP Morgan Overweight → Neutral
Aug-06-21 Downgrade RBC Capital Mkts Outperform → Sector Perform
Aug-06-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-02-20 Initiated Morgan Stanley Overweight
Mar-04-20 Initiated Barclays Overweight
Jan-17-20 Downgrade Wedbush Outperform → Neutral
Jul-23-19 Upgrade JP Morgan Neutral → Overweight
Jul-05-19 Reiterated H.C. Wainwright Buy
Jul-05-19 Reiterated Robert W. Baird Outperform
Mar-01-19 Downgrade JP Morgan Overweight → Neutral
Feb-28-19 Reiterated BofA/Merrill Underperform
Feb-27-19 Downgrade BofA/Merrill Neutral → Underperform
Jan-03-19 Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18 Initiated B. Riley FBR Buy
Nov-09-18 Upgrade Wedbush Neutral → Outperform
May-24-18 Downgrade Wedbush Outperform → Neutral
Apr-02-18 Resumed Leerink Partners Outperform
Nov-15-17 Resumed H.C. Wainwright Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Sep-08-16 Reiterated H.C. Wainwright Buy
Aug-30-16 Upgrade Jefferies Hold → Buy
Aug-18-16 Initiated H.C. Wainwright Buy
Jun-28-16 Initiated Robert W. Baird Outperform
View All

Karyopharm Therapeutics Inc Stock (KPTI) Latest News

pulisher
Jun 14, 2026

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress - TradingView

Jun 14, 2026
pulisher
Jun 14, 2026

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor (NEXPOVIO®) Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress - GlobeNewswire Inc.

Jun 14, 2026
pulisher
Jun 13, 2026

Karyopharm Therapeutics secures EHA Congress acclaim for late-breaking SENTRY trial update - Traders Union

Jun 13, 2026
pulisher
Jun 09, 2026

Cantor Fitzgerald reiterates Overweight on Karyopharm stock - Investing.com UK

Jun 09, 2026
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Jun 09, 2026

Cantor Fitzgerald reiterates Overweight on Karyopharm stock By Investing.com - Investing.com South Africa

Jun 09, 2026
pulisher
Jun 07, 2026

How The Investment Story Is Evolving For Karyopharm Therapeutics (KPTI) - Yahoo Finance

Jun 07, 2026
pulisher
Jun 05, 2026

T. Rowe Price (KPTI) files Schedule 13G/A showing 6.6% position - Stock Titan

Jun 05, 2026
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Jun 03, 2026

Karyopharm to Participate in Webcast Featuring Endometrial Cancer Key Opinion Leader on June 8, 2026 - Karyopharm

Jun 03, 2026
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Jun 02, 2026

Karyopharm Therapeutics Inc. (KPTI) Discusses Phase III SENTRY Trial Results of Selinexor Plus Ruxolitinib in MyelofibrosisSlideshow (NASDAQ:KPTI) 2026-06-02 - Seeking Alpha

Jun 02, 2026
pulisher
Jun 02, 2026

KPTI: Karyopharm's Abstract Accepted for Presentation at Europea - GuruFocus

Jun 02, 2026
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Jun 02, 2026

KPTI: Karyopharm Announces Positive Phase 3 SENTRY Trial Results - GuruFocus

Jun 02, 2026
pulisher
Jun 02, 2026

KPTI: Selinexor plus ruxolitinib nearly doubled spleen response and improved survival in myelofibrosis - TradingView

Jun 02, 2026
pulisher
Jun 02, 2026

Karyopharm reports phase 3 myelofibrosis trial results at ASCO - Investing.com UK

Jun 02, 2026
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Jun 02, 2026

Karyopharm reports phase 3 myelofibrosis trial results at ASCO By Investing.com - Investing.com Nigeria

Jun 02, 2026
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Jun 02, 2026

Karyopharm to Report Data From Phase 3 Trial of Selinexor Plus Ruxolitinib in Myelofibrosis - marketscreener.com

Jun 02, 2026
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Jun 02, 2026

Karyopharm’s myelofibrosis trial selected for EHA presentation By Investing.com - Investing.com South Africa

Jun 02, 2026
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Jun 02, 2026

Karyopharm’s myelofibrosis trial selected for EHA presentation - Investing.com UK

Jun 02, 2026
pulisher
Jun 02, 2026

Karyopharm's Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis Selected for Late-Breaking Oral Presentation at EHA 2026 - Karyopharm

Jun 02, 2026
pulisher
Jun 02, 2026

Cancer trial suggests spleen shrinkage may predict survival in myelofibrosis - Stock Titan

Jun 02, 2026
pulisher
Jun 02, 2026

Karyopharm to Present Results from Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis in Late-Breaking Oral Presentation at ASCO 2026 with Simultaneous Publication in the Journal of Clinical Oncology - Karyopharm

Jun 02, 2026
pulisher
Jun 02, 2026

Karyopharm Therapeutics Presents Results from Phase 3 Sentry Trial of Selinexor Plus Ruxolitinib in Myelofibrosis - marketscreener.com

Jun 02, 2026
pulisher
Jun 01, 2026

Karyopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - Karyopharm

Jun 01, 2026
pulisher
Jun 01, 2026

Karyopharm Therapeutics (KPTI) to Discuss SENTRY Trial Results i - GuruFocus

Jun 01, 2026
pulisher
Jun 01, 2026

Karyopharm to host call on phase 3 myelofibrosis trial results By Investing.com - Investing.com Australia

Jun 01, 2026
pulisher
Jun 01, 2026

Karyopharm to host call on phase 3 myelofibrosis trial results - Investing.com

Jun 01, 2026
pulisher
Jun 01, 2026

Karyopharm to Host Investor Conference Call Featuring Expert Perspectives on the Phase 3 SENTRY Trial in Myelofibrosis Following 2026 ASCO Presentation - Karyopharm

Jun 01, 2026
pulisher
Jun 01, 2026

Myelofibrosis Phase 3 trial data to be detailed on June 2 call - Stock Titan

Jun 01, 2026
pulisher
May 31, 2026

KPTI Q1 2026 Earnings: EPS Beats Estimates Despite Revenue Absence, Stock DipsQuarterly Profit Report - newsline.com

May 31, 2026
pulisher
May 31, 2026

Karyopharm shares rise 10% after mixed Phase 3 SENTRY trial results - MSN

May 31, 2026
pulisher
May 30, 2026

Karyopharm Therapeutics (KPTI) Holds Near $9.10 Amid Low-Volume ConsolidationPercent Below MA - newsline.com

May 30, 2026
pulisher
May 29, 2026

KPTI News | KARYOPHARM THERAPEUTICS INC (NASDAQ:KPTI) - ChartMill

May 29, 2026
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May 28, 2026

Karyopharm (NASDAQ: KPTI) boosts share plans and grants CEO PSU awards - Stock Titan

May 28, 2026
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May 28, 2026

Karyopharm to Participate at the 2026 Jefferies Global Healthcare Conference - Karyopharm

May 28, 2026
pulisher
May 28, 2026

Karyopharm to Speak at 2026 Jefferies Global Healthcare Conference - Intellectia AI

May 28, 2026
pulisher
May 28, 2026

Cancer drug maker Karyopharm joins 2026 Jefferies healthcare summit - Stock Titan

May 28, 2026
pulisher
May 27, 2026

Wall Street Analysts Think Karyopharm Therapeutics (KPTI) Could Surge 70.46%: Read This Before Placing a Bet - Yahoo Finance

May 27, 2026
pulisher
May 26, 2026

Karyopharm (KPTI) director Christy Oliger receives 15,508 RSU equity award - Stock Titan

May 26, 2026
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May 26, 2026

Karyopharm (KPTI) director awarded 15,508 RSUs vesting in 2027 - Stock Titan

May 26, 2026
pulisher
May 26, 2026

Chen Schor of Karyopharm (KPTI) receives 15,508 RSU award - Stock Titan

May 26, 2026
pulisher
May 26, 2026

Karyopharm Therapeutics (KPTI) director receives 15,508 RSUs in equity award - Stock Titan

May 26, 2026
pulisher
May 26, 2026

Karyopharm (KPTI) director receives 15,508 RSU equity award vesting in 2027 - Stock Titan

May 26, 2026
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May 26, 2026

Karyopharm (NASDAQ: KPTI) director gets 15,508 RSUs vesting in 2027 - Stock Titan

May 26, 2026
pulisher
May 26, 2026

Karyopharm Therapeutics spotlights selinexor milestones, ASCO data and cancer trial readouts - MSN

May 26, 2026
pulisher
May 26, 2026

Karyopharm Therapeutics Spotlights Selinexor Milestones, ASCO Data and Cancer Trial Readouts - Barchart

May 26, 2026

Karyopharm Therapeutics Inc Stock (KPTI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$97.46
price down icon 0.40%
$30.03
price down icon 0.03%
$90.80
price up icon 0.29%
$54.27
price down icon 1.09%
ONC ONC
$268.20
price up icon 1.41%
$160.06
price up icon 4.02%
Cap:     |  Volume (24h):