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Oruka Therapeutics Inc stock is traded at $73.86, with a volume of 433.24K. It is down -3.67% in the last 24 hours and down -19.89% over the past month. Oruka Therapeutics Inc a clinical-stage biopharmaceutical company focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications. Its programs are to treat and potentially modify disease by targeting mechanisms with efficacy and safety involved in disease pathology and the activity of pathogenic tissue-resident memory T cells (TRMs). Its program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, hidradenitis suppurativa (HS), psoriatic arthritis (PsA), and other conditions.
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Previous Close:
$76.68
Open:
$75.53
24h Volume:
433.24K
Relative Volume:
0.53
Market Cap:
$4.89B
Revenue:
Net Income/Loss:
$-116.25M
P/E Ratio:
-30.89
EPS:
-2.3912
Net Cash Flow:
$-91.19M
1W Performance:
-4.42%
1M Performance:
-19.89%
6M Performance:
+12.68%
1Y Performance:
+164.65%
1-Day Range:
Value
$73.86
$77.89
1-Week Range:
Value
$75.41
$82.95
52-Week Range:
Value
$24.88
$115.52

Oruka Therapeutics Inc Stock (ORKA) Company Profile

Name
Name
Oruka Therapeutics Inc
Name
Phone
650-606-7910
Name
Address
855 OAK GROVE AVE., MENLO PARK
Name
Employee
68
Name
Twitter
Name
Next Earnings Date
2026-11-11
Name
Latest SEC Filings
Name
ORKA's Discussions on Twitter

Compare ORKA vs VRTX, MRNA, REGN, ARGX, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
ORKA icon
ORKA
Oruka Therapeutics Inc
73.86 4.89B 0 -116.25M -91.19M -2.3912
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
509.86 129.23B 12.34B 4.34B 3.71B 16.87
MRNA icon
MRNA
Moderna Inc
237.75 94.92B 2.23B -3.19B -1.60B -8.1462
REGN icon
REGN
Regeneron Pharmaceuticals Inc
800.00 82.36B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
848.32 53.35B 4.16B 1.29B 734.26M 19.58
ONC icon
ONC
Beone Medicines Ltd Adr
371.60 42.04B 5.76B 514.49M 1.10B 4.4813

Oruka Therapeutics Inc Stock (ORKA) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-18-25 Initiated Piper Sandler Overweight
Nov-13-25 Initiated Jefferies Buy
Oct-27-25 Initiated Guggenheim Buy
Oct-13-25 Initiated Barclays Overweight
May-22-25 Initiated BTIG Research Buy
Feb-04-25 Initiated Wolfe Research Outperform
Oct-11-24 Initiated Stifel Buy
Oct-07-24 Initiated H.C. Wainwright Buy
Sep-17-24 Initiated Leerink Partners Outperform
Sep-16-24 Initiated TD Cowen Buy
Sep-13-24 Initiated Jefferies Buy
Feb-27-18 Initiated Ascendiant Capital Markets Buy
Oct-09-13 Initiated Dawson James Buy
View All

Oruka Therapeutics Inc Stock (ORKA) Latest News

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Oct 14, 2026

Oruka Therapeutics senior vice president Arjun Agarwal sells $805,888 in stock - Investing.com

Oct 14, 2026
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Oct 14, 2026

Form 4 Oruka Therapeutics Inc: Arjun Agarwal (Senior Vice President, Finance) For: 12 October - Investing.com India

Oct 14, 2026
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Oct 14, 2026

Form 4 Oruka Therapeutics Inc: Arjun Agarwal (Senior Vice President, Finance) For: 12 October - Investing.com UK

Oct 14, 2026
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Oct 13, 2026

Oruka Therapeutics' Arjun Agarwal Executes Option Exercises and Sells Nearly 10,000 Shares - Kalkine Media

Oct 13, 2026
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Oct 13, 2026

An officer proposes selling 9,999 Oruka Therapeutics (ORKA) shares acquired through stock options. - Stock Titan

Oct 13, 2026
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Oct 03, 2026

Form 4 Oruka Therapeutics Inc For: 2 October By Investing.com - Investing.com South Africa

Oct 03, 2026
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Oct 02, 2026

Oruka Therapeutics (ORKA) CEO Lawrence Klein Sells 25,000 Shares - GuruFocus

Oct 02, 2026
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Oct 02, 2026

Oruka Therapeutics CEO Klein sells $2.09m in stock - Investing.com

Oct 02, 2026
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Oct 02, 2026

Form 4 Oruka Therapeutics Inc For: 2 October By Investing.com - Investing.com Nigeria

Oct 02, 2026
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Oct 01, 2026

25,000 shares from a stock-option exercise are proposed for sale at Oruka Therapeutics (NASDAQ: ORKA). - Stock Titan

Oct 01, 2026
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Sep 23, 2026

Oruka Therapeutics Announces Positive Week 28 Data for ORKA-001 from the Ongoing EVERLAST-A Trial Showing Deepening of Responses Without Additional Dosing - GlobeNewswire Inc.

Sep 23, 2026
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Sep 22, 2026

Oruka Therapeutics general counsel Paul Quinlan sells $936k in stock - Investing.com Nigeria

Sep 22, 2026
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Sep 22, 2026

Form 4 Oruka Therapeutics Inc For: 22 September By Investing.com - Investing.com Nigeria

Sep 22, 2026
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Sep 22, 2026

Form 4 Oruka Therapeutics Inc For: 22 September By Investing.com - Investing.com Canada

Sep 22, 2026
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Sep 22, 2026

Oruka Therapeutics general counsel Paul Quinlan sells $936k in stock - Investing.com Canada

Sep 22, 2026
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Sep 22, 2026

Form 4 Oruka Therapeutics Inc For: 22 September - Investing.com India

Sep 22, 2026
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Sep 22, 2026

Oruka Therapeutics general counsel Paul Quinlan sells $936k in stock - Investing.com

Sep 22, 2026
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Sep 21, 2026

Details on Warrant Exercise and Subsequent Share Sales by Oruka Therapeutics' General Counsel - Kalkine Media

Sep 21, 2026
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Sep 21, 2026

Oruka Therapeutics SVP Arjun Agarwal Sells 533 Shares Under Rule 10b5-1 Plan - Kalkine Media

Sep 21, 2026
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Sep 21, 2026

Oruka Therapeutics SVP Arjun Agarwal sells $51,034 in ORKA stock - Investing.com

Sep 21, 2026
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Sep 21, 2026

Oruka Therapeutics SVP Arjun Agarwal sells $51,034 in ORKA stock By Investing.com - Investing.com South Africa

Sep 21, 2026
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Sep 21, 2026

Oruka Therapeutics SVP Arjun Agarwal sells $51,034 in ORKA stock By Investing.com - Investing.com Nigeria

Sep 21, 2026
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Sep 21, 2026

Oruka Therapeutics (NASDAQ: ORKA) insider plans new share sale after recent 10b5-1 trades - Stock Titan

Sep 21, 2026
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Sep 16, 2026

Oruka Therapeutics SVP Agarwal sells over $926k in common stock By Investing.com - Investing.com South Africa

Sep 16, 2026
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Sep 15, 2026

Oruka Therapeutics SVP Agarwal sells over $926k in common stock - Investing.com India

Sep 15, 2026
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Sep 15, 2026

Oruka Therapeutics general counsel Paul Quinlan sells $99,442 in stock - Investing.com

Sep 15, 2026
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Sep 15, 2026

Oruka Therapeutics CEO Lawrence Klein sells $234,680 in ORKA stock - Investing.com

Sep 15, 2026
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Sep 15, 2026

Oruka Therapeutics general counsel Paul Quinlan sells $99,442 in stock By Investing.com - Investing.com Canada

Sep 15, 2026
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Sep 15, 2026

Oruka Therapeutics COO Sandler sells $86,713 in common stock - Investing.com

Sep 15, 2026
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Sep 15, 2026

Oruka (ORKA) legal chief sells shares to cover RSU taxes - Stock Titan

Sep 15, 2026
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Sep 15, 2026

Oruka (ORKA) finance SVP sells 10K shares after option exercises - Stock Titan

Sep 15, 2026
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Sep 10, 2026

Oruka Therapeutics to Attend Morgan Stanley Global Healthcare Conference - Bitget

Sep 10, 2026
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Sep 09, 2026

Morgan Stanley's New York healthcare conference includes Oruka - Stock Titan

Sep 09, 2026
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Sep 09, 2026

Oruka Therapeutics to Attend the 2026 Morgan Stanley Global Healthcare Conference - GlobeNewswire

Sep 09, 2026
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Sep 05, 2026

About Oruka Therapeutics Inc aStock - Coinbase

Sep 05, 2026
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Sep 03, 2026

H.C. Wainwright reiterates Oruka Therapeutics stock rating at buy By Investing.com - Investing.com Canada

Sep 03, 2026
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Sep 03, 2026

H.C. Wainwright reiterates Oruka Therapeutics stock rating at buy - Investing.com UK

Sep 03, 2026
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Sep 02, 2026

UBS Maintains Oruka Therapeutics(ORKA.US) With Buy Rating, Maintains Target Price $130 - Moomoo

Sep 02, 2026
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Sep 02, 2026

Oruka Therapeutics CEO Klein sells $6.8m in stock By Investing.com - Investing.com South Africa

Sep 02, 2026
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Sep 02, 2026

Oruka Therapeutics COO Laura Sandler sells $459,101 in stock By Investing.com - Investing.com South Africa

Sep 02, 2026
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Sep 02, 2026

Oruka Therapeutics(ORKA.US) Officer Sells US$6.89 Million in Common Stock - Moomoo

Sep 02, 2026
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Sep 01, 2026

Oruka Therapeutics COO Laura Sandler sells $459,101 in stock By Investing.com - Investing.com Nigeria

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics CEO Klein sells $6.8m in stock By Investing.com - Investing.com Nigeria

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics COO Laura Sandler sells $459,101 in stock - Investing.com

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics CEO Klein sells $6.8m in stock - Investing.com

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics COO Laura Sandler sells $459,101 in stock - Investing.com India

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics COO Laura Sandler sells $459,101 in stock By Investing.com - Investing.com Canada

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics CEO Klein sells $6.8m in stock - Investing.com UK

Sep 01, 2026
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Sep 01, 2026

Insider at Oruka Therapeutics (ORKA) plans stock sale from option exercise - Stock Titan

Sep 01, 2026
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Sep 01, 2026

Oruka Therapeutics (NASDAQ: ORKA) officer lines up another stock sale after two summer trades - stocktitan.net

Sep 01, 2026

Oruka Therapeutics Inc Stock (ORKA) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Oruka Therapeutics Inc Stock (ORKA) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Arjun Agarwal
Officer
Oct 12 '26
Proposed Sale
82.11
9,999
821,018
0
Agarwal Arjun
Senior Vice President, Finance
Oct 12 '26
Sale
80.60
9,999
805,889
14,219
Klein Lawrence Otto
Chief Executive Officer
Oct 01 '26
Option Exercise
7.80
25,000
195,000
948,128
Klein Lawrence Otto
Chief Executive Officer
Oct 01 '26
Sale
83.62
25,000
2,090,593
923,128
LAWRENCE KLEIN
Director
Oct 01 '26
Proposed Sale
83.29
25,000
2,082,250
0
Arjun Agarwal
Officer
Sep 21 '26
Proposed Sale
94.96
533
50,614
0
Quinlan Paul T
General Counsel
Sep 21 '26
Option Exercise
7.80
10,000
78,000
39,995
Agarwal Arjun
Senior Vice President, Finance
Sep 21 '26
Sale
95.75
533
51,035
14,219
Quinlan Paul T
General Counsel
Sep 21 '26
Sale
93.64
10,000
936,417
29,995
Quinlan Paul T
General Counsel
Sep 15 '26
Sale
95.71
1,039
99,443
29,995
$40.68
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$51.45
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$114.37
price up icon 0.79%
$53.09
price down icon 0.34%
$29.23
price up icon 3.84%
$61.09
price up icon 2.37%
Cap:     |  Volume (24h):