44.50
price down icon1.42%   -0.64
 
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Septerna Inc stock is traded at $44.50, with a volume of 630.34K. It is down -1.42% in the last 24 hours and up +28.84% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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Previous Close:
$45.14
Open:
$45
24h Volume:
630.34K
Relative Volume:
1.44
Market Cap:
$2.08B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-39.99
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
+14.60%
1M Performance:
+28.84%
6M Performance:
+61.82%
1Y Performance:
+280.99%
1-Day Range:
Value
$43.64
$46.50
1-Week Range:
Value
$38.05
$51.10
52-Week Range:
Value
$10.74
$51.10

Septerna Inc Stock (SEPN) Company Profile

Name
Name
Septerna Inc
Name
Phone
650-338-3533
Name
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Name
Employee
130
Name
Twitter
Name
Next Earnings Date
2026-08-10
Name
Latest SEC Filings
Name
SEPN's Discussions on Twitter

Compare SEPN vs VRTX, REGN, ARGX, RVMD, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SEPN icon
SEPN
Septerna Inc
44.50 2.25B 45.95M -48.88M 109.67M -1.1129
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
505.75 133.25B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
803.48 82.16B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
851.29 54.80B 4.16B 1.29B 734.26M 19.58
RVMD icon
RVMD
Revolution Medicines Inc
203.71 43.99B 742.00K -1.37B -1.07B -7.0731
ONC icon
ONC
Beone Medicines Ltd Adr
347.48 40.62B 5.76B 514.49M 1.10B 4.4813

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-19-25 Initiated Raymond James Strong Buy
Dec-15-25 Initiated Truist Buy
Nov-14-25 Upgrade Wells Fargo Equal Weight → Overweight
Jun-23-25 Initiated H.C. Wainwright Buy
Feb-18-25 Downgrade Wells Fargo Overweight → Equal Weight
Nov-19-24 Initiated Cantor Fitzgerald Overweight
Nov-19-24 Initiated JP Morgan Overweight
Nov-19-24 Initiated TD Cowen Buy
Nov-19-24 Initiated Wells Fargo Overweight
View All

Septerna Inc Stock (SEPN) Latest News

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Aug 14, 2026

Ra Capital Management sells $63.45m in Septerna stock By Investing.com - Investing.com Nigeria

Aug 14, 2026
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Aug 14, 2026

Septerna(SEPN.US) 10% Shareholder Sells US$7.4 Million in Common Stock - Moomoo

Aug 14, 2026
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Aug 14, 2026

Third Rock Ventures V, L.P. director sells $7.4m Septerna shares - Investing.com South Africa

Aug 14, 2026
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Aug 14, 2026

RA Capital Management Offloads 1.49 Million Septerna Shares at $42.50 Each - Kalkine Media

Aug 14, 2026
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Aug 14, 2026

Septerna (SEPN): RA Capital funds disclose sale of 1.49M common shares - Stock Titan

Aug 14, 2026
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Aug 14, 2026

Form 4: Third Rock Ventures reports acquisition/exercise transactions in SEPN - Stock Titan

Aug 14, 2026
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Aug 14, 2026

RA Capital group (SEPN) discloses 11.8% Septerna stake and major block sales - Stock Titan

Aug 14, 2026
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Aug 14, 2026

HC Wainwright Predicts Septerna's Q3 Earnings (NASDAQ:SEPN) - MarketBeat

Aug 14, 2026
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Aug 14, 2026

Driehaus Capital Management (SEPN) discloses 4.43M-share Septerna stake in 13G/A - Stock Titan

Aug 14, 2026
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Aug 13, 2026

Septerna (NASDAQ:SEPN) COO Elizabeth Bhatt Sells 25,000 Shares of Stock - MarketBeat

Aug 13, 2026
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Aug 13, 2026

Septerna president & COO Elizabeth Bhatt disposes of $1.1m in stock - Investing.com Australia

Aug 13, 2026
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Aug 13, 2026

Septerna (SEPN) President & COO exercises 25,000 options and sells shares under 10b5-1 plan - Stock Titan

Aug 13, 2026
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Aug 13, 2026

Septerna (NASDAQ:SEPN) Trading Down 6.1%Here's Why - MarketBeat

Aug 13, 2026
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Aug 13, 2026

JonesTrading Forecasts Strong Price Appreciation for Septerna (NASDAQ:SEPN) Stock - MarketBeat

Aug 13, 2026
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Aug 13, 2026

Wall Street Analysts Are Bullish on Top NA Picks - The Globe and Mail

Aug 13, 2026
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Aug 12, 2026

Stifel Maintains Septerna(SEPN.US) With Buy Rating, Raises Target Price to $49 - Moomoo

Aug 12, 2026
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Aug 12, 2026

Septerna, Inc. SEC Filing (Aug 12, 2026) - Stock Titan

Aug 12, 2026
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Aug 12, 2026

SEPN (SEPN) plans NASDAQ sale of 746,500 shares worth $35.97M - Stock Titan

Aug 12, 2026
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Aug 12, 2026

Does Septerna (SEPN) Pair Narrowing Losses With A Cash Runway That Truly Supports Its Pipeline Strategy? - simplywall.st

Aug 12, 2026
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Aug 12, 2026

Septerna Inc stock hits all-time high at 50.0 USD By Investing.com - Investing.com Canada

Aug 12, 2026
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Aug 12, 2026

Septerna (NASDAQ:SEPN) Sees Unusually-High Trading Volume on Analyst Upgrade - MarketBeat

Aug 12, 2026
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Aug 12, 2026

SEPN Maintained by Wells Fargo -- Price Target Raised to $50 - GuruFocus

Aug 12, 2026
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Aug 12, 2026

H.C. Wainwright raises Septerna stock price target to $60 on SEP-479 progress - Investing.com

Aug 12, 2026
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Aug 12, 2026

A Quick Look at Today's Ratings for Septerna(SEPN.US), With a Forecast Between $49 to $60 - Moomoo

Aug 12, 2026
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Aug 12, 2026

Septerna (NASDAQ:SEPN) Price Target Raised to $50.00 at Wells Fargo & Company - MarketBeat

Aug 12, 2026
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Aug 12, 2026

Septerna (NASDAQ:SEPN) Price Target Raised to $60.00 - MarketBeat

Aug 12, 2026
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Aug 12, 2026

SEPN Maintained by HC Wainwright & Co. -- Price Target Raised to $60 - GuruFocus

Aug 12, 2026
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Aug 12, 2026

Septerna Shares (SEPN) Surge 23% Following Positive SEP-479 Signal, Exceeding Analyst Predictions - TechStock²

Aug 12, 2026
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Aug 11, 2026

Stifel raises Septerna stock price target to $49 on SEP-479 outlook - Investing.com UK

Aug 11, 2026
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Aug 11, 2026

Septerna, Inc. Stock 12‑Month Price Target Raised to $47, Implies 21% Upside - TradingView

Aug 11, 2026
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Aug 11, 2026

Seer (SEPN) insiders plan sale of 29,000 shares after option exercise - Stock Titan

Aug 11, 2026
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Aug 11, 2026

SEPN Maintains by Guggenheim -- Price Target Raised to $51.00 - GuruFocus

Aug 11, 2026
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Aug 11, 2026

Raymond James Maintains Septerna(SEPN.US) With Buy Rating, Cuts Target Price to $49 - Moomoo

Aug 11, 2026
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Aug 11, 2026

Septerna (NASDAQ:SEPN) Stock Price Up 9% Following Earnings Beat - MarketBeat

Aug 11, 2026
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Aug 11, 2026

Stifel raises Septerna stock price target to $49 on SEP-479 outlook By Investing.com - Investing.com India

Aug 11, 2026
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Aug 11, 2026

Guggenheim raises Septerna stock price target to $51 on pipeline progress - Investing.com

Aug 11, 2026
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Aug 11, 2026

SEPN SWOT Analysis: Key Insights from 10-Q Filing - GuruFocus

Aug 11, 2026
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Aug 10, 2026

Septerna, Inc. (SEPN) Reports Q2 Loss, Beats Revenue Estimates - Yahoo Finance

Aug 10, 2026
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Aug 10, 2026

Septerna (NASDAQ:SEPN) Releases Earnings Results, Beats Expectations By $0.14 EPS - MarketBeat

Aug 10, 2026
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Aug 10, 2026

Septerna Q2 2026 Results: Revenue Surges to $26.7M on Novo Nordisk Collaboration - scanx.trade

Aug 10, 2026
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Aug 10, 2026

Septerna Q2 Loss Narrows, Revenue Rises - marketscreener.com

Aug 10, 2026
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Aug 10, 2026

Earnings Flash (SEPN) Septerna Posts Q2 Loss Per Share $0.29, vs. FactSet Est of $0.43 Loss - marketscreener.com

Aug 10, 2026
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Aug 10, 2026

Septerna, Inc. reports results for the quarter ended June 30Earnings Summary - TradingView

Aug 10, 2026
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Aug 10, 2026

Earnings Flash (SEPN) Septerna, Inc. Reports Q2 Revenue $26.7M, vs. FactSet Est of $19.2M - marketscreener.com

Aug 10, 2026
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Aug 10, 2026

Septerna Highlights Business Progress and Reports Second Quarter 2026 Financial Results - The Manila Times

Aug 10, 2026
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Aug 10, 2026

Septerna Q2 revenue beats analyst estimates, driven by Novo Nordisk partnership - TradingView

Aug 10, 2026
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Aug 10, 2026

Septerna (SEPN) boosts collaboration revenue and extends cash runway into 2029 - Stock Titan

Aug 10, 2026
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Aug 10, 2026

Septerna, Inc. Reports Earnings Results for the Second Quarter and Six Months Ended June 30, 2026 - marketscreener.com

Aug 10, 2026
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Aug 10, 2026

Septerna (NASDAQ:SEPN) Hits New 1-Year HighStill a Buy? - MarketBeat

Aug 10, 2026
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Aug 09, 2026

Price to book forward of Septerna, Inc. – NASDAQ:SEPN - TradingView

Aug 09, 2026
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Aug 09, 2026

Septerna Inc (SEPN) Earnings Forecast: Future EPS & Revenue Growth Estimates - tradingkey.com

Aug 09, 2026

Septerna Inc Stock (SEPN) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$63.32
price down icon 0.52%
$58.60
price up icon 0.07%
$36.20
price down icon 0.22%
$123.74
price down icon 2.05%
$228.65
price up icon 0.67%
ONC ONC
$347.48
price down icon 2.40%
Cap:     |  Volume (24h):