24.21

3.28% 0.77

After Hours: 24.21

Septerna Inc (SEPN)

Overview News Price History Discussions Forecast

Septerna Inc stock is traded at $24.21, with a volume of 134.21K. It is up +3.28% in the last 24 hours and down -19.27% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.

Previous Close:

$23.44

Open:

$23.69

24h Volume:

134.21K

Relative Volume:

0.45

Market Cap:

$1.09B

Revenue:

$45.95M

Net Income/Loss:

$-48.88M

P/E Ratio:

-21.75

EPS:

-1.1129

Net Cash Flow:

$109.67M

1W Performance:

+0.41%

1M Performance:

-19.27%

6M Performance:

+44.54%

1Y Performance:

+296.89%

1-Day Range:

$23.50

$25.07

1-Week Range:

$22.97

$25.33

52-Week Range:

$4.66

$32.63

Septerna Inc Stock (SEPN) Company Profile

Name

Septerna Inc

Sector

Healthcare (1114)

Industry

Biotechnology (623)

Phone

650-338-3533

Address

250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO

Employee

130

Twitter

Next Earnings Date

2026-03-26

Latest SEC Filings

SEPN's Discussions on Twitter

Compare SEPN vs VRTX, REGN, ALNY, ARGX, INSM

Stocks	Price	Market Cap	Revenue	Net Income	Cash Flow	EPS
SEPN Septerna Inc	24.21	1.05B	45.95M	-48.88M	109.67M	-1.1129
VRTX Vertex Pharmaceuticals Inc	454.97	113.96B	12.07B	3.95B	3.19B	15.33
REGN Regeneron Pharmaceuticals Inc	749.47	78.41B	14.34B	4.50B	3.77B	41.56
ALNY Alnylam Pharmaceuticals Inc	328.70	40.85B	3.71B	313.75M	465.38M	2.2571
ARGX Argen X Se Adr	697.05	42.05B	4.16B	1.29B	734.26M	19.58
INSM Insmed Inc	148.31	29.99B	606.42M	-1.28B	-997.58M	-6.403

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date	Action	Analyst	Rating Change
Dec-19-25	Initiated	Raymond James	Strong Buy
Dec-15-25	Initiated	Truist	Buy
Nov-14-25	Upgrade	Wells Fargo	Equal Weight → Overweight
Jun-23-25	Initiated	H.C. Wainwright	Buy
Feb-18-25	Downgrade	Wells Fargo	Overweight → Equal Weight
Nov-19-24	Initiated	Cantor Fitzgerald	Overweight
Nov-19-24	Initiated	JP Morgan	Overweight
Nov-19-24	Initiated	TD Cowen	Buy
Nov-19-24	Initiated	Wells Fargo	Overweight

View All

Septerna Inc Stock (SEPN) Latest News

Mar 25, 2026

Septerna, Inc. (NASDAQ:SEPN) Receives Average Recommendation of "Moderate Buy" from Analysts - MarketBeat

Mar 25, 2026

Mar 24, 2026

Septerna tops Q4 loss expectations as collaboration revenue lifts results - MSN

Mar 24, 2026

J.P. Morgan Maintains Septerna(SEPN.US) With Buy Rating, Announces Target Price $38 - Moomoo

Mar 24, 2026

Septerna (NASDAQ:SEPN) Given New $38.00 Price Target at JPMorgan Chase & Co. - MarketBeat

Mar 24, 2026

JP Morgan Raises Price Target for Septerna (SEPN) to $38 | SEPN Stock News - GuruFocus

Mar 24, 2026

Septerna price target raised to $38 from $34 at JPMorgan - TipRanks

Mar 24, 2026

Mar 23, 2026

Should Septerna’s New ATM and Shelf Offering Strategy Require Action From Septerna (SEPN) Investors? - simplywall.st

Mar 23, 2026

Mar 21, 2026

Big Picture: How volatile is Septerna Inc stock2026 WrapUp & Free Low Drawdown Momentum Trade Ideas - baoquankhu1.vn

Mar 21, 2026

Mar 19, 2026

Septerna (SEPN) Expected to Announce Earnings on Thursday - MarketBeat

Mar 19, 2026

Mar 17, 2026

Layoff Watch: Will Septerna Inc outperform the market in YEARTrade Entry Report & Long-Term Safe Investment Ideas - baoquankhu1.vn

Mar 17, 2026

Mar 16, 2026

Septerna (SEPN) Is Down 13.5% After Launching US$150 Million ATM Equity Program and Filing Shelves - simplywall.st

Mar 16, 2026

Mar 15, 2026

Checkpoint Capital L.P. Trims Stock Position in Septerna, Inc. $SEPN - MarketBeat

Mar 15, 2026

Mar 14, 2026

Avoro Capital Advisors LLC Grows Stock Holdings in Septerna, Inc. $SEPN - MarketBeat

Mar 14, 2026

Analysts Conflicted on These Technology Names: Fortinet (FTNT), Septerna, Inc. (SEPN) and Oracle (ORCL) - The Globe and Mail

Mar 12, 2026

Mar 11, 2026

Truist Financial Forecasts Strong Price Appreciation for Septerna (NASDAQ:SEPN) Stock - MarketBeat

Mar 11, 2026

Septerna (SEPN) Q4 Loss Despite Revenue Surge Reinforces Bearish Profitability Narrative - simplywall.st

Mar 11, 2026

Wells Fargo Reaffirms Their Buy Rating on Septerna, Inc. (SEPN) - The Globe and Mail

Mar 11, 2026

Truist Lifts Price Target on Septerna to $35 From $34, Keeps Buy Rating - marketscreener.com

Mar 11, 2026

Cantor Fitzgerald Maintains Overweight on Septerna, Inc. (SEPN) March 2026 - Meyka

Mar 11, 2026

Mar 10, 2026

Truist raises Septerna stock price target to $35 on trial progress - Investing.com

Mar 10, 2026

Cantor Fitzgerald reiterates Septerna stock rating on platform value By Investing.com - Investing.com Australia

Mar 10, 2026

Cantor Fitzgerald reiterates Septerna stock rating on platform value - Investing.com

Mar 10, 2026

Septerna (SEPN) Reports Narrower Q4 Loss of $0.24/Share as Revenue Climbs to $24.1M - AlphaStreet

Mar 10, 2026

Septerna beats fourth quarter loss estimates on collaboration revenue By Investing.com - Investing.com Canada

Mar 10, 2026

Septerna beats fourth quarter loss estimates on collaboration revenue - Investing.com

Mar 10, 2026

Decoding Septerna Inc (SEPN): A Strategic SWOT Insight - GuruFocus

Mar 10, 2026

Mar 09, 2026