37.38
price up icon2.92%   1.06
 
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Septerna Inc stock is traded at $37.38, with a volume of 109.79K. It is up +2.92% in the last 24 hours and down -3.81% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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Previous Close:
$36.32
Open:
$36.78
24h Volume:
109.79K
Relative Volume:
0.22
Market Cap:
$1.74B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-33.59
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
+1.30%
1M Performance:
-3.81%
6M Performance:
+44.16%
1Y Performance:
+60.22%
1-Day Range:
Value
$36.22
$38.36
1-Week Range:
Value
$34.36
$38.73
52-Week Range:
Value
$17.55
$51.10

Septerna Inc Stock (SEPN) Company Profile

Name
Name
Septerna Inc
Name
Phone
650-338-3533
Name
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Name
Employee
130
Name
Twitter
Name
Next Earnings Date
2026-11-09
Name
Latest SEC Filings
Name
SEPN's Discussions on Twitter

Compare SEPN vs VRTX, MRNA, REGN, ARGX, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SEPN icon
SEPN
Septerna Inc
37.38 1.74B 45.95M -48.88M 109.67M -1.1129
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
509.74 129.20B 12.34B 4.34B 3.71B 16.87
MRNA icon
MRNA
Moderna Inc
238.40 95.18B 2.23B -3.19B -1.60B -8.1462
REGN icon
REGN
Regeneron Pharmaceuticals Inc
801.26 82.49B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
849.01 53.39B 4.16B 1.29B 734.26M 19.58
ONC icon
ONC
Beone Medicines Ltd Adr
371.37 42.01B 5.76B 514.49M 1.10B 4.4813

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date Action Analyst Rating Change
Jun-11-26 Initiated Guggenheim Buy
May-01-26 Initiated Stifel Buy
Dec-19-25 Initiated Raymond James Strong Buy
Dec-15-25 Initiated Truist Buy
Nov-14-25 Upgrade Wells Fargo Equal Weight → Overweight
Jun-23-25 Initiated H.C. Wainwright Buy
Feb-18-25 Downgrade Wells Fargo Overweight → Equal Weight
Nov-19-24 Initiated Cantor Fitzgerald Overweight
Nov-19-24 Initiated JP Morgan Overweight
Nov-19-24 Initiated TD Cowen Buy
Nov-19-24 Initiated Wells Fargo Overweight
View All

Septerna Inc Stock (SEPN) Latest News

pulisher
Oct 01, 2026

Septerna Officer Samira Shaikhly Files Form 144 to Sell 12,592 Common Shares - Kalkine Media

Oct 01, 2026
pulisher
Oct 01, 2026

Officer Daniel Long proposes selling 10,001 Septerna (SEPN) common shares. - Stock Titan

Oct 01, 2026
pulisher
Oct 01, 2026

An officer proposes selling 12,592 Septerna (SEPN) shares acquired by exercising stock options. - Stock Titan

Oct 01, 2026
pulisher
Sep 17, 2026

Septerna, Inc.Common Stock (NQ: SEPN - The Chronicle-Journal

Sep 17, 2026
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Sep 10, 2026

Septerna's CMO Rajiv Patni Granted 275,000 Stock Options with 10-Year Expiry - Kalkine Media

Sep 10, 2026
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Sep 10, 2026

Septerna (SEPN) awards CMO 275,000 options at $37.37 - Stock Titan

Sep 10, 2026
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Sep 10, 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - manilatimes.net

Sep 10, 2026
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Sep 10, 2026

Septerna Announces Inducement Grant Under Nasdaq Listing Rule - TradingView

Sep 10, 2026
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Sep 10, 2026

A new medical chief gets an option to buy up to 275,000 Septerna shares at $37.37 - Stock Titan

Sep 10, 2026
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Sep 10, 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - lincolnjournal.com

Sep 10, 2026
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Sep 10, 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - Carroll County Mirror-Democrat

Sep 10, 2026
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Sep 10, 2026

Septerna at Cantor Fitzgerald conference: pipeline broadens, cash holds By Investing.com - Investing.com Canada

Sep 10, 2026
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Sep 10, 2026

Septerna at Cantor Fitzgerald conference: pipeline broadens, cash holds - Investing.com India

Sep 10, 2026
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Sep 08, 2026

Septerna at Wells Fargo conference: platform bets and pipeline catalysts By Investing.com - Investing.com Canada

Sep 08, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock By Investing.com - Investing.com South Africa

Sep 04, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock By Investing.com - Investing.com Nigeria

Sep 04, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock By Investing.com - Investing.com Canada

Sep 04, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock - Investing.com

Sep 04, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock By Investing.com - Investing.com India

Sep 04, 2026
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Sep 03, 2026

New Septerna (SEPN) chief medical officer reports zero share holdings - Stock Titan

Sep 03, 2026
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Sep 03, 2026

Septerna SVP Drug Discovery Daniel D. Long disposes of common shares worth $126,081.52 - Bitget

Sep 03, 2026
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Sep 01, 2026

Septerna to Participate in Upcoming Investor Conferences - manilatimes.net

Sep 01, 2026
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Sep 01, 2026

Septerna to Participate in Upcoming Investor Conferences - marketscreener.com

Sep 01, 2026
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Aug 31, 2026

Septerna (SEPN) Declines 1.95% to $38.15, Approaching Key Support at $36.24Parabolic SAR - vinanet.vn

Aug 31, 2026
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Aug 31, 2026

Septerna (SEPN) Declines 1.95% to $38.15, Approaching Key Support at $36.24Momentum Factor - dars.gov.et

Aug 31, 2026
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Aug 30, 2026

Septerna Inc Q2 Income From Operations USD -1 - moomoo.com

Aug 30, 2026
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Aug 28, 2026

Septerna (SEPN) Is Down 7.1% After Broad Russell Index Additions Has The Bull Case Changed? - sahmcapital.com

Aug 28, 2026
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Aug 28, 2026

Septerna stock soars 315% on Novo Nordisk deal and key drug milestones - Pluang

Aug 28, 2026
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Aug 25, 2026

Septerna appoints Rajiv Patni as chief medical officer By Investing.com - Investing.com Canada

Aug 25, 2026
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Aug 25, 2026

Septerna Appoints Rajiv Patni as Chief Medical Officer - TipRanks

Aug 25, 2026
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Aug 25, 2026

Septerna appoints Rajiv Patni as chief medical officer By Investing.com - Investing.com India

Aug 25, 2026
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Aug 25, 2026

Septerna appoints Rajiv Patni as chief medical officer By Investing.com - Investing.com Nigeria

Aug 25, 2026
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Aug 25, 2026

Septerna appoints Rajiv Patni as chief medical officer By Investing.com - Investing.com UK

Aug 25, 2026
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Aug 25, 2026

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer - The Manila Times

Aug 25, 2026
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Aug 25, 2026

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer - Barchart.com

Aug 25, 2026
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Aug 25, 2026

Septerna (SEPN) Results at a Glance: The Bottom-Line Figure Outpaces Its Comparison in the Latest Reading; Market Response: The Share Price Adds 1.30% in the Latest SessionEarnings Beat Streak - siam.in

Aug 25, 2026
pulisher
Aug 25, 2026

Septerna (SEPN) Results at a Glance: The Bottom-Line Figure Outpaces Its Comparison in the Latest Reading; Market Response: The Share Price Adds 1.30% in the Latest SessionMargin Guidance - dars.gov.et

Aug 25, 2026
pulisher
Aug 25, 2026

Septerna (SEPN) Results at a Glance: The Bottom-Line Figure Outpaces Its Comparison in the Latest Reading; Market Response: The Share Price Adds 1.30% in the Latest SessionGuidance Revision Trend - vinanet.vn

Aug 25, 2026
pulisher
Aug 24, 2026

Septerna (SEPN) Shares: Finishes 2.10% Higher at $40.84 for the Current Session; Immediate View: Support at $38.80 and Resistance at $42.88 Frame the Range in Latest TradingStandard Deviation - vinanet.vn

Aug 24, 2026
pulisher
Aug 24, 2026

Septerna (SEPN) Shares: Finishes 2.10% Higher at $40.84 for the Current Session; Immediate View: Support at $38.80 and Resistance at $42.88 Frame the Range in Latest TradingSector ETF Flow - siam.in

Aug 24, 2026
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Aug 20, 2026

Driehaus Capital Management Expands Septerna Inc (SEPN) Stake in Second Quarter - GuruFocus

Aug 20, 2026
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Aug 20, 2026

Septerna (NASDAQ:SEPN) Stock Price Down 8%Time to Sell? - MarketBeat

Aug 20, 2026
pulisher
Aug 20, 2026

Analysts Offer Insights on NA Companies: Cerebras Systems, Inc. Class A (CBRS), Septerna, Inc. (SEPN) and TWFG, Inc. Class A (TWFG) - theglobeandmail.com

Aug 20, 2026
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Aug 19, 2026

SEPN Maintained by JP Morgan -- Price Target Raised to $48 - GuruFocus

Aug 19, 2026
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Aug 19, 2026

Septerna (NASDAQ:SEPN) Price Target Raised to $48.00 - MarketBeat

Aug 19, 2026
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Aug 19, 2026

J.P. Morgan Maintains Septerna(SEPN.US) With Buy Rating, Raises Target Price to $48 - Moomoo

Aug 19, 2026
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Aug 19, 2026

SEPTERNA, INC. : JP MORGAN RAISES TARGET PRICE TO $48 FROM $38 - Bitget

Aug 19, 2026
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Aug 19, 2026

4,211,659 Shares in Septerna, Inc. $SEPN Acquired by Trv Gp Vi LLC - MarketBeat

Aug 19, 2026
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Aug 19, 2026

Trv Gp V LLC Takes Position in Septerna, Inc. $SEPN - MarketBeat

Aug 19, 2026
pulisher
Aug 17, 2026

Septerna, Inc. (SEPN) Receives a Rating Update from a Top Analyst - The Globe and Mail

Aug 17, 2026

Septerna Inc Stock (SEPN) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Septerna Inc Stock (SEPN) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
SAMIRA SHAIKHLY
Officer
Oct 01 '26
Proposed Sale
39.13
12,592
492,725
0
Long Daniel D.
SVP, Drug Discovery
Sep 01 '26
Option Exercise
2.76
3,333
9,199
99,745
Long Daniel D.
SVP, Drug Discovery
Sep 01 '26
Sale
37.83
3,333
126,078
96,412
RA CAPITAL MANAGEMENT, L.P.
Director
Aug 12 '26
Sale
42.50
1,493,000
63,452,500
725,443
Third Rock Ventures V, L.P.
10% Owner
Aug 12 '26
Proposed Sale
51.00
147,200
7,507,200
0
RA Capital Nexus Fund III, L.P
Affiliate
Aug 12 '26
Proposed Sale
48.19
746,500
35,973,835
0
RA Capital Healthcare Fund LP
affiliate
Aug 12 '26
Proposed Sale
48.19
746,500
35,973,835
0
Bhatt Elizabeth
President and COO
Aug 11 '26
Option Exercise
5.79
25,000
144,658
199,209
Bhatt Elizabeth
President and COO
Aug 11 '26
Sale
44.00
25,000
1,100,000
174,209
ELIZABETH P. BHATT
Officer
Aug 11 '26
Proposed Sale
38.85
29,000
1,126,650
0
$19.34
price up icon 0.05%
$11.41
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$12.09
price up icon 0.25%
VIR VIR
$10.49
price up icon 0.77%
$24.07
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$13.87
price up icon 0.58%
Cap:     |  Volume (24h):