38.13
price down icon0.83%   -0.32
 
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Septerna Inc stock is traded at $38.13, with a volume of 293.04K. It is down -0.83% in the last 24 hours and down -5.90% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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Previous Close:
$38.45
Open:
$38.41
24h Volume:
293.04K
Relative Volume:
0.67
Market Cap:
$1.78B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-34.26
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
-3.47%
1M Performance:
-5.90%
6M Performance:
+62.67%
1Y Performance:
+125.49%
1-Day Range:
Value
$37.49
$38.80
1-Week Range:
Value
$36.98
$41.09
52-Week Range:
Value
$16.21
$51.10

Septerna Inc Stock (SEPN) Company Profile

Name
Name
Septerna Inc
Name
Phone
650-338-3533
Name
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Name
Employee
130
Name
Twitter
Name
Next Earnings Date
2026-11-09
Name
Latest SEC Filings
Name
SEPN's Discussions on Twitter

Compare SEPN vs VRTX, REGN, MRNA, ARGX, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SEPN icon
SEPN
Septerna Inc
38.13 1.78B 45.95M -48.88M 109.67M -1.1129
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
522.38 132.40B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
796.02 81.95B 14.92B 4.42B 3.79B 41.04
MRNA icon
MRNA
Moderna Inc
194.82 77.78B 2.23B -3.19B -1.60B -8.1462
ARGX icon
ARGX
Argen X Se Adr
962.22 60.20B 4.16B 1.29B 734.26M 19.58
RVMD icon
RVMD
Revolution Medicines Inc
199.86 42.84B 742.00K -1.37B -1.07B -7.0731

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-19-25 Initiated Raymond James Strong Buy
Dec-15-25 Initiated Truist Buy
Nov-14-25 Upgrade Wells Fargo Equal Weight → Overweight
Jun-23-25 Initiated H.C. Wainwright Buy
Feb-18-25 Downgrade Wells Fargo Overweight → Equal Weight
Nov-19-24 Initiated Cantor Fitzgerald Overweight
Nov-19-24 Initiated JP Morgan Overweight
Nov-19-24 Initiated TD Cowen Buy
Nov-19-24 Initiated Wells Fargo Overweight
View All

Septerna Inc Stock (SEPN) Latest News

pulisher
Sep 18, 2026

Septerna, Inc. (SEPN) Investor Outlook: Strong Buy Ratings Signal 37% Potential Upside - DirectorsTalk Interviews

Sep 18, 2026
pulisher
Sep 17, 2026

Septerna, Inc.Common Stock (NQ: SEPN - The Chronicle-Journal

Sep 17, 2026
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Sep 14, 2026

Septerna (SEPN) Heads To Healthcare Conferences, Is The Valuation Already Too Rich? - finance.yahoo.com

Sep 14, 2026
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Sep 11, 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - The Manila Times

Sep 11, 2026
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Sep 10, 2026

Septerna's CMO Rajiv Patni Granted 275,000 Stock Options with 10-Year Expiry - Kalkine Media

Sep 10, 2026
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Sep 10, 2026

Septerna (SEPN) awards CMO 275,000 options at $37.37 - Stock Titan

Sep 10, 2026
pulisher
Sep 10, 2026

Septerna Announces Inducement Grant Under Nasdaq Listing Rule - TradingView

Sep 10, 2026
pulisher
Sep 10, 2026

A new medical chief gets an option to buy up to 275,000 Septerna shares at $37.37 - Stock Titan

Sep 10, 2026
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Sep 10, 2026

Wells Fargo Sticks to Their Buy Rating for Septerna, Inc. (SEPN) - The Globe and Mail

Sep 10, 2026
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Sep 10, 2026

Septerna at Cantor Fitzgerald conference: pipeline broadens, cash holds By Investing.com - Investing.com Canada

Sep 10, 2026
pulisher
Sep 10, 2026

Septerna at Cantor Fitzgerald conference: pipeline broadens, cash holds - Investing.com India

Sep 10, 2026
pulisher
Sep 09, 2026

Septerna (SEPN) Q2 2026 Earnings: $0.29 Per-Share Loss Beats Estimates by 33.26% as Stock Gains 3.28%Performance Review - dars.gov.et

Sep 09, 2026
pulisher
Sep 08, 2026

Septerna at Wells Fargo conference: platform bets and pipeline catalysts By Investing.com - Investing.com Canada

Sep 08, 2026
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Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock By Investing.com - Investing.com South Africa

Sep 04, 2026
pulisher
Sep 04, 2026

Septerna SVP Daniel Long sells $126,077 in company stock - investing.com

Sep 04, 2026
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Sep 03, 2026

New Septerna (SEPN) chief medical officer reports zero share holdings - Stock Titan

Sep 03, 2026
pulisher
Sep 01, 2026

Septerna to Participate in Upcoming Investor Conferences - manilatimes.net

Sep 01, 2026
pulisher
Aug 31, 2026

Septerna (SEPN) Declines 1.95% to $38.15, Approaching Key Support at $36.24Parabolic SAR - vinanet.vn

Aug 31, 2026
pulisher
Aug 30, 2026

Septerna Inc Q2 Income From Operations USD -1 - moomoo.com

Aug 30, 2026
pulisher
Aug 28, 2026

Septerna (SEPN) Is Down 7.1% After Broad Russell Index Additions Has The Bull Case Changed? - sahmcapital.com

Aug 28, 2026
pulisher
Aug 28, 2026

Septerna stock soars 315% on Novo Nordisk deal and key drug milestones - Pluang

Aug 28, 2026
pulisher
Aug 25, 2026

Septerna appoints Rajiv Patni as chief medical officer By Investing.com - Investing.com Canada

Aug 25, 2026
pulisher
Aug 25, 2026

Septerna Appoints Rajiv Patni as Chief Medical Officer - TipRanks

Aug 25, 2026
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Aug 25, 2026

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer - The Manila Times

Aug 25, 2026
pulisher
Aug 25, 2026

Septerna (SEPN) Results at a Glance: The Bottom-Line Figure Outpaces Its Comparison in the Latest Reading; Market Response: The Share Price Adds 1.30% in the Latest SessionManagement Tone Analysis - dars.gov.et

Aug 25, 2026
pulisher
Aug 24, 2026

Septerna (SEPN) Shares: Finishes 2.10% Higher at $40.84 for the Current Session; Immediate View: Support at $38.80 and Resistance at $42.88 Frame the Range in Latest TradingStandard Deviation - vinanet.vn

Aug 24, 2026
pulisher
Aug 20, 2026

Driehaus Capital Management Expands Septerna Inc (SEPN) Stake in Second Quarter - GuruFocus

Aug 20, 2026
pulisher
Aug 20, 2026

Septerna (NASDAQ:SEPN) Stock Price Down 8%Time to Sell? - MarketBeat

Aug 20, 2026
pulisher
Aug 20, 2026

Analysts Offer Insights on NA Companies: Cerebras Systems, Inc. Class A (CBRS), Septerna, Inc. (SEPN) and TWFG, Inc. Class A (TWFG) - theglobeandmail.com

Aug 20, 2026
pulisher
Aug 19, 2026

SEPN Maintained by JP Morgan -- Price Target Raised to $48 - GuruFocus

Aug 19, 2026
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Aug 19, 2026

Septerna (NASDAQ:SEPN) Price Target Raised to $48.00 - MarketBeat

Aug 19, 2026
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Aug 19, 2026

J.P. Morgan Maintains Septerna(SEPN.US) With Buy Rating, Raises Target Price to $48 - Moomoo

Aug 19, 2026
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Aug 19, 2026

SEPTERNA, INC. : JP MORGAN RAISES TARGET PRICE TO $48 FROM $38 - Bitget

Aug 19, 2026
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Aug 19, 2026

4,211,659 Shares in Septerna, Inc. $SEPN Acquired by Trv Gp Vi LLC - MarketBeat

Aug 19, 2026
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Aug 19, 2026

Trv Gp V LLC Takes Position in Septerna, Inc. $SEPN - MarketBeat

Aug 19, 2026
pulisher
Aug 17, 2026

Septerna, Inc. (SEPN) Receives a Rating Update from a Top Analyst - The Globe and Mail

Aug 17, 2026
pulisher
Aug 15, 2026

37,700 Shares in Septerna, Inc. $SEPN Purchased by Renaissance Technologies LLC - MarketBeat

Aug 15, 2026
pulisher
Aug 15, 2026

Ra Capital Management sells $63.45m in Septerna stock By Investing.com - Investing.com Australia

Aug 15, 2026
pulisher
Aug 14, 2026

Ra Capital Management sells $63.45m in Septerna stock - Investing.com

Aug 14, 2026
pulisher
Aug 14, 2026

Septerna(SEPN.US) 10% Shareholder Sells US$7.4 Million in Common Stock - Moomoo

Aug 14, 2026
pulisher
Aug 14, 2026

Third Rock Ventures V, L.P. director sells $7.4m Septerna shares - Investing.com South Africa

Aug 14, 2026
pulisher
Aug 14, 2026

RA Capital Management Offloads 1.49 Million Septerna Shares at $42.50 Each - Kalkine Media

Aug 14, 2026
pulisher
Aug 14, 2026

Septerna (SEPN): RA Capital funds disclose sale of 1.49M common shares - Stock Titan

Aug 14, 2026
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Aug 14, 2026

Form 4: Third Rock Ventures reports acquisition/exercise transactions in SEPN - Stock Titan

Aug 14, 2026
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Aug 14, 2026

RA Capital group (SEPN) discloses 11.8% Septerna stake and major block sales - Stock Titan

Aug 14, 2026
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Aug 14, 2026

HC Wainwright Predicts Septerna's Q3 Earnings (NASDAQ:SEPN) - MarketBeat

Aug 14, 2026
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Aug 14, 2026

Driehaus Capital Management (SEPN) discloses 4.43M-share Septerna stake in 13G/A - Stock Titan

Aug 14, 2026
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Aug 13, 2026

Septerna (NASDAQ:SEPN) COO Elizabeth Bhatt Sells 25,000 Shares of Stock - MarketBeat

Aug 13, 2026
pulisher
Aug 13, 2026

Septerna president & COO Elizabeth Bhatt disposes of $1.1m in stock - Investing.com Nigeria

Aug 13, 2026

Septerna Inc Stock (SEPN) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$58.29
price up icon 1.11%
$36.13
price down icon 1.87%
$121.55
price up icon 2.71%
$249.59
price up icon 1.25%
ONC ONC
$359.97
price down icon 1.38%
$199.86
price up icon 4.78%
Cap:     |  Volume (24h):