33.10
price down icon1.11%   -0.37
 
loading
Septerna Inc stock is traded at $33.10, with a volume of 242.03K. It is down -1.11% in the last 24 hours and down -8.18% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
See More
Previous Close:
$33.47
Open:
$33.88
24h Volume:
242.03K
Relative Volume:
0.60
Market Cap:
$1.49B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-29.74
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
-0.90%
1M Performance:
-8.18%
6M Performance:
+28.47%
1Y Performance:
+144.10%
1-Day Range:
Value
$32.48
$34.97
1-Week Range:
Value
$31.85
$35.11
52-Week Range:
Value
$10.62
$38.04

Septerna Inc Stock (SEPN) Company Profile

Name
Name
Septerna Inc
Name
Phone
650-338-3533
Name
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Name
Employee
130
Name
Twitter
Name
Next Earnings Date
2026-08-10
Name
Latest SEC Filings
Name
SEPN's Discussions on Twitter

Compare SEPN vs VRTX, REGN, ARGX, RVMD, ALNY

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SEPN icon
SEPN
Septerna Inc
33.10 1.49B 45.95M -48.88M 109.67M -1.1129
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
477.36 121.16B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
656.01 68.78B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
918.22 57.44B 4.16B 1.29B 734.26M 19.58
RVMD icon
RVMD
Revolution Medicines Inc
189.23 40.23B 742.00K -1.37B -1.07B -7.0731
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
271.77 36.28B 4.29B 577.22M 641.34M 4.2086

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-19-25 Initiated Raymond James Strong Buy
Dec-15-25 Initiated Truist Buy
Nov-14-25 Upgrade Wells Fargo Equal Weight → Overweight
Jun-23-25 Initiated H.C. Wainwright Buy
Feb-18-25 Downgrade Wells Fargo Overweight → Equal Weight
Nov-19-24 Initiated Cantor Fitzgerald Overweight
Nov-19-24 Initiated JP Morgan Overweight
Nov-19-24 Initiated TD Cowen Buy
Nov-19-24 Initiated Wells Fargo Overweight
View All

Septerna Inc Stock (SEPN) Latest News

pulisher
Jul 20, 2026

3 Small-Cap Stocks with ‘Strong Buy’ Ratings and 40%+ Upside, According to Analysts - TipRanks

Jul 20, 2026
pulisher
Jul 17, 2026

Septerna President and COO Elizabeth Bhatt sells 4,000 shares for $135,974 - Bitget

Jul 17, 2026
pulisher
Jul 17, 2026

Septerna president & COO Elizabeth Bhatt sells $135,974 in stock - Investing.com

Jul 17, 2026
pulisher
Jul 17, 2026

Form 4 Septerna Inc For: 17 July By Investing.com - Investing.com Nigeria

Jul 17, 2026
pulisher
Jul 17, 2026

Septerna (SEPN) president sells 4,000 shares and exercises 4,000 options under plan - Stock Titan

Jul 17, 2026
pulisher
Jul 17, 2026

Septerna (SEPN) 10K Form and Latest SEC Filings 2026 - MarketBeat

Jul 17, 2026
pulisher
Jul 17, 2026

Septerna, Inc. (SEPN) Reports Q3 Loss, Misses Revenue Estimates - MSN

Jul 17, 2026
pulisher
Jul 15, 2026

Septerna, Inc. SEC Filing (Jul 15, 2026) - Stock Titan

Jul 15, 2026
pulisher
Jul 15, 2026

Septerna Inc. (SEPN) Declines 1.33%, Approaching Key Support at $32.38Relative Volume - dars.gov.et

Jul 15, 2026
pulisher
Jul 11, 2026

Is Septerna (SEPN) Fully Valued Following Its Russell Index Inclusions? - simplywall.st

Jul 11, 2026
pulisher
Jul 10, 2026

Septerna (SEPN) Is Up 7.1% After Broad Russell Growth Index Additions Has The Bull Case Changed? - Sahm

Jul 10, 2026
pulisher
Jul 09, 2026

Septerna Inc stock hits all-time high at 38.01 USD - Investing.com UK

Jul 09, 2026
pulisher
Jul 09, 2026

Septerna Inc stock hits all-time high at 38.01 USD By Investing.com - Investing.com Australia

Jul 09, 2026
pulisher
Jul 08, 2026

Septerna (SEPN) 43rd Annual J.P. Morgan Healthcare Conference 2025 Summary - Quartr

Jul 08, 2026
pulisher
Jul 07, 2026

SEPN Q1 2026 Earnings: Smaller-than-expected loss as clinical-stage biotech advancesEarnings Yield Spread - dars.gov.et

Jul 07, 2026
pulisher
Jul 05, 2026

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors? - Yahoo Finance

Jul 05, 2026
pulisher
Jul 05, 2026

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors? - The Motley Fool

Jul 05, 2026
pulisher
Jul 02, 2026

Septerna Inc. (SEPN) Q1 2026 Earnings: Narrower-Than-Expected Loss Signals Steady Pipeline ProgressRevenue Surprise History - dars.gov.et

Jul 02, 2026
pulisher
Jul 02, 2026

Septerna (SEPN) SVP Long exercises options and sells 3,333 shares in Rule 10b5-1 trades - Stock Titan

Jul 02, 2026
pulisher
Jul 02, 2026

Is Septerna, Inc. (SEPN) Stock a Biotech Opportunity With a Potential First-in-Class Hypoparathyroidism Treatment? - Yahoo Finance

Jul 02, 2026
pulisher
Jul 02, 2026

Septerna Inc. (SEPN) Slides 2.63% as Stock Tests Key Support Near $32Max Pain Level - dars.gov.et

Jul 02, 2026
pulisher
Jul 02, 2026

Analysts Offer Insights on Technology Companies: Septerna, Inc. (SEPN) and Strategy (MSTR) - The Globe and Mail

Jul 02, 2026
pulisher
Jul 02, 2026

Septerna Inc. (SEPN) Slips 1.79% as Stock Tests Key Support LevelsInitial Balance - dars.gov.et

Jul 02, 2026
pulisher
Jul 01, 2026

Guggenheim cuts Septerna stock price target to $45 on CSU study risk By Investing.com - Investing.com India

Jul 01, 2026
pulisher
Jul 01, 2026

SEPN Maintained by Guggenheim -- Price Target Lowered to $45.00 - GuruFocus

Jul 01, 2026
pulisher
Jul 01, 2026

Truist Securities Adjusts Septerna Price Target to $43 From $35, Maintains Buy Rating - marketscreener.com

Jul 01, 2026
pulisher
Jul 01, 2026

SEPN Maintains Buy RatingPrice Target Raised to $43.00 by Tru - GuruFocus

Jul 01, 2026
pulisher
Jul 01, 2026

SEPN Reiterated by HC Wainwright & Co. -- Price Target Maintained at $40 - GuruFocus

Jul 01, 2026
pulisher
Jul 01, 2026

Septerna (SEPN) Is Down 7.1% After Broad Russell Index Additions Has The Bull Case Changed? - simplywall.st

Jul 01, 2026
pulisher
Jul 01, 2026

Guggenheim cuts Septerna stock price target to $45 on CSU study risk - Investing.com South Africa

Jul 01, 2026
pulisher
Jul 01, 2026

Analysts Are Bullish on Top Technology Stocks: Akamai (AKAM), Procore Technologies (PCOR) - The Globe and Mail

Jul 01, 2026
pulisher
Jul 01, 2026

Septerna stock maintained at Buy by H.C. Wainwright after rival setback - Investing.com

Jul 01, 2026
pulisher
Jul 01, 2026

H.C. Wainwright Maintains Septerna(SEPN.US) With Buy Rating, Maintains Target Price $40 - Moomoo

Jul 01, 2026
pulisher
Jul 01, 2026

Truist raises Septerna stock price target to $43 on hypoparathyroidism outlook - Investing.com

Jul 01, 2026
pulisher
Jul 01, 2026

5 Best Up and Coming Pharmaceutical Stocks to Buy Now - Insider Monkey

Jul 01, 2026
pulisher
Jun 30, 2026

Septerna, Inc. Files 8-K Detailing Annual Meeting Results and Company Information – June 2026 - Minichart

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna chief people officer Samira Shaikhly sells $76,622 in stock - Investing.com UK

Jun 30, 2026
pulisher
Jun 30, 2026

Form 4 Septerna Inc For: 30 June By Investing.com - Investing.com UK

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (NASDAQ: SEPN) director-linked funds get 15,000-share option - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna chief people officer Samira Shaikhly sells $76,622 in stock By Investing.com - Investing.com South Africa

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (SEPN) CPO exercises options and sells 2,178 shares - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (SEPN) director Bernard Coulie receives 15,000 stock options - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (SEPN) director Abraham Bassan receives grant of 15,000 stock options - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (SEPN) director granted 15,000 options for RA Capital funds - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna (NASDAQ: SEPN) 2026 meeting elects directors and backs EY as auditor - Stock Titan

Jun 30, 2026
pulisher
Jun 30, 2026

SEPN Q1 2026 Earnings: EPS Beat of 55.3% Overshadowed by Pre-Revenue StatusSurprise Factor Analysis - dars.gov.et

Jun 30, 2026
pulisher
Jun 30, 2026

Cantor Fitzgerald Maintains Septerna(SEPN.US) With Buy Rating, Raises Target Price to $60 - Moomoo

Jun 30, 2026
pulisher
Jun 30, 2026

Septerna Inc. (SEPN) Q1 2026 Earnings: Smaller-Than-Expected Loss as Biotech Advances PipelineEarnings Manipulation Risk - dars.gov.et

Jun 30, 2026
pulisher
Jun 29, 2026

Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares? - Yahoo Finance

Jun 29, 2026

Septerna Inc Stock (SEPN) Financials Data

Revenue

loading

Net Income

loading

Cash Flow

loading

EPS

loading
$106.92
price down icon 0.46%
$117.67
price up icon 0.84%
$35.01
price down icon 0.26%
$58.83
price down icon 0.32%
ONC ONC
$325.90
price down icon 0.27%
$271.77
price up icon 1.13%
Cap:     |  Volume (24h):