28.36
price up icon1.58%   0.44
after-market After Hours: 28.36
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Septerna Inc stock is traded at $28.36, with a volume of 346.80K. It is up +1.58% in the last 24 hours and up +9.67% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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Previous Close:
$27.92
Open:
$27.93
24h Volume:
346.80K
Relative Volume:
1.08
Market Cap:
$1.28B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-25.48
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
+5.23%
1M Performance:
+9.67%
6M Performance:
+10.95%
1Y Performance:
+199.16%
1-Day Range:
Value
$27.93
$29.89
1-Week Range:
Value
$25.79
$29.89
52-Week Range:
Value
$9.045
$32.63

Septerna Inc Stock (SEPN) Company Profile

Name
Name
Septerna Inc
Name
Phone
650-338-3533
Name
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Name
Employee
130
Name
Twitter
Name
Next Earnings Date
2026-05-21
Name
Latest SEC Filings
Name
SEPN's Discussions on Twitter

Compare SEPN vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SEPN icon
SEPN
Septerna Inc
28.36 1.26B 45.95M -48.88M 109.67M -1.1129
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
434.52 110.03B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
638.88 67.37B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
806.46 50.76B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
297.45 40.12B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
151.56 32.68B 742.00K -1.37B -1.07B -7.0731

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-19-25 Initiated Raymond James Strong Buy
Dec-15-25 Initiated Truist Buy
Nov-14-25 Upgrade Wells Fargo Equal Weight → Overweight
Jun-23-25 Initiated H.C. Wainwright Buy
Feb-18-25 Downgrade Wells Fargo Overweight → Equal Weight
Nov-19-24 Initiated Cantor Fitzgerald Overweight
Nov-19-24 Initiated JP Morgan Overweight
Nov-19-24 Initiated TD Cowen Buy
Nov-19-24 Initiated Wells Fargo Overweight
View All

Septerna Inc Stock (SEPN) Latest News

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May 24, 2026

SEPN Q1 2026 Earnings: Smaller-Than-Expected Loss Amidst Pipeline ProgressEarnings Revision Downgrade - Newser

May 24, 2026
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May 23, 2026

SEPN Q1 2026 Earnings: Narrower-Than-Expected Loss Highlights Cost DisciplineExpert Momentum Signals - Newser

May 23, 2026
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May 23, 2026

Septerna Inc. (SEPN) Q1 2026 Earnings: Smaller-than-Expected Loss Drives Positive Market ResponseCommunity Pattern Alerts - Newser

May 23, 2026
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May 23, 2026

Septerna Inc. (SEPN) Q1 2026 Earnings: Narrower-Than-Expected Loss Highlights Cost DisciplineROA Comparison - Newser

May 23, 2026
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May 22, 2026

New Forecasts: Here's What Analysts Think The Future Holds For Septerna, Inc. (NASDAQ:SEPN) - Sahm

May 22, 2026
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May 22, 2026

Septerna, Inc. (SEPN) Competitors - Meyka

May 22, 2026
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May 21, 2026

Septerna (SEPN) Q1 2026 Crushes Forecasts — EPS $-0.19 vs $-0.42Free Stock Community - Newser

May 21, 2026
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May 19, 2026

Why Septerna (SEPN) Is Up 11.6% After Q1 Revenue Surge And Narrowed Losses - simplywall.st

May 19, 2026
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May 17, 2026

Party Time: Brokers Just Made Major Increases To Their Septerna, Inc. (NASDAQ:SEPN) Earnings Forecasts - Yahoo Finance

May 17, 2026
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May 15, 2026

Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported And Analysts Are Boosting Their Estimates - Yahoo Finance

May 15, 2026
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May 15, 2026

Q2 Earnings Forecast for Septerna Issued By HC Wainwright - MarketBeat

May 15, 2026
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May 14, 2026

TradingKey - TradingKey

May 14, 2026
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May 14, 2026

Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported Its First-Quarter Results And Analysts Are Updating Their Forecasts - simplywall.st

May 14, 2026
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May 13, 2026

Septerna Inc. (SEPN) Stock Price | Live Quotes & Charts | NASDAQ - StocksToTrade

May 13, 2026
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May 13, 2026

Septerna, Inc. (SEPN) reports Q1 loss, tops revenue estimates - MSN

May 13, 2026
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May 13, 2026

H.C. Wainwright reiterates Septerna stock rating at buy, $40 target By Investing.com - Investing.com South Africa

May 13, 2026
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May 13, 2026

H.C. Wainwright reiterates Septerna stock rating at buy, $40 target - Investing.com

May 13, 2026
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May 13, 2026

Septerna (SEPN) Q1 Loss Narrows To US$8.6 Million Challenging Bearish Earnings Narratives - Sahm

May 13, 2026
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May 12, 2026

Wells Fargo Maintains Septerna(SEPN.US) With Buy Rating, Maintains Target Price $48 - Moomoo

May 12, 2026
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May 12, 2026

TD Cowen Maintains Septerna(SEPN.US) With Buy Rating - Moomoo

May 12, 2026
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May 12, 2026

Septerna Highlights Business Progress and Reports First Quarter 2026 Financial Results - The Manila Times

May 12, 2026
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May 11, 2026

Wells Fargo Upgrades Septerna (SEPN) - MSN

May 11, 2026
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May 11, 2026

Septerna, Inc. (SEPN) Reports Q1 Loss, Tops Revenue Estimates - sharewise.com

May 11, 2026
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May 11, 2026

Septerna Q1 revenue rises sharply helped by Novo Nordisk collaboration - TradingView

May 11, 2026
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May 11, 2026

Septerna (NASDAQ: SEPN) grows Q1 revenue to $26.5M, trims loss - Stock Titan

May 11, 2026
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May 11, 2026

Septerna, Inc. 1Q 2026: Revenue $26.5M, EPS $(0.19) — 10-Q Summary - TradingView

May 11, 2026
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May 11, 2026

Septerna, Inc. Reports Earnings Results for the First Quarter Ended March 31, 2026 - marketscreener.com

May 11, 2026
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May 11, 2026

Earnings Flash (SEPN) Septerna, Inc. Reports Q1 Revenue $26.5M, vs. FactSet Est of $17.0M - marketscreener.com

May 11, 2026
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May 11, 2026

Septerna (SEPN) Q1 2026 revenue jumps on Novo Nordisk deal, loss narrows - Stock Titan

May 11, 2026
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May 11, 2026

Septerna moves chronic hives pill toward Phase 2 after Phase 1 study - Stock Titan

May 11, 2026
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May 09, 2026

HC Wainwright & Co. Maintains Septerna (SEPN) Buy Recommendation - MSN

May 09, 2026
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May 08, 2026

How Analyst Upgrade and Conference Spotlight Will Impact Septerna (SEPN) Investors - Yahoo Finance

May 08, 2026
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May 08, 2026

Septerna, Inc. (SEPN) Stock Analysis: Unpacking a Potential 84% Upside in the Healthcare Biotech Arena - DirectorsTalk Interviews

May 08, 2026
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May 08, 2026

Should you add Septerna (SEPN) to your watchlist today? (Weakens) 2026-05-07Continuation Pattern - newser.com

May 08, 2026
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May 05, 2026

Septerna to Present at Bank of America Securities Health Care Conference - The Manila Times

May 05, 2026
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May 05, 2026

Septerna CEO to give webcast presentation from Las Vegas on May 12 - Stock Titan

May 05, 2026
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May 01, 2026

Septerna, Inc. ($SEPN) CEO 2025 Pay Revealed - Quiver Quantitative

May 01, 2026
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May 01, 2026

Stifel Maintains Septerna(SEPN.US) With Buy Rating, Maintains Target Price $43 - Moomoo

May 01, 2026
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May 01, 2026

Septerna (NASDAQ:SEPN) Now Covered by Stifel Nicolaus - MarketBeat

May 01, 2026
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May 01, 2026

Septerna, Inc. (NASDAQ:SEPN) Sees Significant Growth in Short Interest - MarketBeat

May 01, 2026
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Apr 30, 2026

Stifel Initiates Septerna(SEPN.US) With Buy Rating, Announces Target Price $43 - Moomoo

Apr 30, 2026
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Apr 30, 2026

Septerna | DEF 14A: Definitive information statements - Moomoo

Apr 30, 2026
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Apr 30, 2026

Septerna (NASDAQ: SEPN) details 2026 vote on directors and auditor - Stock Titan

Apr 30, 2026
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Apr 30, 2026

Septerna, Inc. (SEPN) reports Q4 loss, tops revenue estimates - MSN

Apr 30, 2026
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Apr 30, 2026

[ARS] Septerna, Inc. SEC Filing - Stock Titan

Apr 30, 2026
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Apr 26, 2026

Septerna (SEPN) price target increased by 34.39% to 46.41 - MSN

Apr 26, 2026

Septerna Inc Stock (SEPN) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$29.96
price down icon 2.98%
$106.24
price down icon 3.00%
$92.14
price up icon 1.33%
$54.50
price up icon 1.77%
ONC ONC
$310.25
price up icon 0.20%
$151.56
price down icon 1.41%
Cap:     |  Volume (24h):