27.14
price down icon1.20%   -0.33
 
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Upstream Bio Inc stock is traded at $27.14, with a volume of 305.42K. It is down -1.20% in the last 24 hours and up +14.42% over the past month. Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.
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Previous Close:
$27.47
Open:
$28
24h Volume:
305.42K
Relative Volume:
0.70
Market Cap:
$1.47B
Revenue:
$2.22M
Net Income/Loss:
$-40.51M
P/E Ratio:
-21.13
EPS:
-1.2847
Net Cash Flow:
$-46.53M
1W Performance:
-2.20%
1M Performance:
+14.42%
6M Performance:
+134.78%
1Y Performance:
+32.97%
1-Day Range:
Value
$26.78
$28.25
1-Week Range:
Value
$26.78
$29.55
52-Week Range:
Value
$5.14
$33.00

Upstream Bio Inc Stock (UPB) Company Profile

Name
Name
Upstream Bio Inc
Name
Phone
781-208-2466
Name
Address
890 WINTER STREET, SUITE 200, WALTHAM
Name
Employee
0
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
UPB's Discussions on Twitter

Compare UPB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
UPB
Upstream Bio Inc
27.14 1.48B 2.22M -40.51M -46.53M -1.2847
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
452.04 113.14B 11.74B 3.68B 3.34B 14.19
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REGN
Regeneron Pharmaceuticals Inc
741.29 78.49B 14.25B 4.58B 3.88B 41.77
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ARGX
Argen X Se Adr
877.94 54.76B 3.06B 1.28B 447.35M 19.67
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ALNY
Alnylam Pharmaceuticals Inc
397.55 54.51B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
INSM
Insmed Inc
197.01 41.64B 447.02M -1.18B -906.14M -6.1812

Upstream Bio Inc Stock (UPB) Upgrades & Downgrades

Date Action Analyst Rating Change
Nov-18-25 Initiated Evercore ISI Outperform
Oct-14-25 Initiated Truist Buy
Nov-05-24 Initiated JP Morgan Overweight
Nov-05-24 Initiated Piper Sandler Overweight
Nov-05-24 Initiated TD Cowen Buy
Nov-05-24 Initiated William Blair Outperform
View All

Upstream Bio Inc Stock (UPB) Latest News

pulisher
01:43 AM

Financial Analysis: Precision BioSciences (NASDAQ:DTIL) & Upstream Bio (NASDAQ:UPB) - Defense World

01:43 AM
pulisher
Dec 13, 2025

Bain Capital Life Sciences Investors LLC Raises Holdings in Upstream Bio, Inc. $UPB - MarketBeat

Dec 13, 2025
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Dec 10, 2025

Norges Bank Acquires New Position in Upstream Bio, Inc. $UPB - MarketBeat

Dec 10, 2025
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Dec 08, 2025

Can Upstream Bio Stock Hold Up When Markets Turn? - Trefis

Dec 08, 2025
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Dec 07, 2025

Contrasting Upstream Bio (UPB) & The Competition - Defense World

Dec 07, 2025
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Dec 06, 2025

Geode Capital Management LLC Buys 235,958 Shares of Upstream Bio, Inc. $UPB - MarketBeat

Dec 06, 2025
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Dec 05, 2025

Lifesci Capital Predicts Upstream Bio FY2025 Earnings - Defense World

Dec 05, 2025
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Dec 05, 2025

Upstream Bio: Maintaining Buy Rating On Verekitug Success In Phase 2 CRSwNP Study (UPB) - Seeking Alpha

Dec 05, 2025
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Dec 04, 2025

UPB: Virectib's robust phase 2 results and unique mechanism set the stage for pivotal trials in 2026 - TradingView

Dec 04, 2025
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Dec 04, 2025

Lifesci Capital Forecasts Upstream Bio FY2025 Earnings - MarketBeat

Dec 04, 2025
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Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Shares Down 8%Here's What Happened - MarketBeat

Dec 03, 2025
pulisher
Dec 03, 2025

Stocks of Upstream Bio Inc (UPB) are poised to climb above their peers - setenews.com

Dec 03, 2025
pulisher
Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Coverage Initiated by Analysts at Lifesci Capital - MarketBeat

Dec 03, 2025
pulisher
Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Now Covered by Analysts at Lifesci Capital - Defense World

Dec 03, 2025
pulisher
Dec 02, 2025

LifeSci Capital Initiates Coverage of Upstream Bio (UPB) with Outperform Recommendation - Nasdaq

Dec 02, 2025
pulisher
Dec 02, 2025

Upstream Bio initiated with an Outperform at LifeSci Capital - TipRanks

Dec 02, 2025
pulisher
Dec 02, 2025

Is Upstream Bio Inc. stock attractive for ETFsJuly 2025 Snapshot & Fast Moving Stock Watchlists - Newser

Dec 02, 2025
pulisher
Nov 30, 2025

What analysts say about Upstream Bio Inc stockEarnings Miss Alerts & Free High Yield Market Plays - earlytimes.in

Nov 30, 2025
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Nov 30, 2025

Why retail investors favor Upstream Bio Inc. stockJuly 2025 Highlights & Detailed Earnings Play Alerts - BỘ NỘI VỤ

Nov 30, 2025
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Nov 28, 2025

Severe Asthma Clinical Pipeline 2025: A Comprehensive Review of 50+ Emerging Therapies from 40+ Innovators, says DelveInsight - Barchart.com

Nov 28, 2025
pulisher
Nov 26, 2025

You might want to take a look at Upstream Bio Inc (UPB) now - Setenews

Nov 26, 2025
pulisher
Nov 26, 2025

Upstream Bio (NASDAQ:UPB) Shares Up 8.5%Should You Buy? - MarketBeat

Nov 26, 2025
pulisher
Nov 25, 2025

Upstream Bio (UPB): Evaluating Valuation After 10% Share Price Surge - Yahoo Finance

Nov 25, 2025
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Nov 25, 2025

Promising Outlook for Upstream Bio, Inc. Driven by Verekitug’s Clinical Advancements - TipRanks

Nov 25, 2025
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Nov 25, 2025

Upstream Bio to Participate in Upcoming December Investor Conferences - The Manila Times

Nov 25, 2025
pulisher
Nov 24, 2025

Upstream Bio stock reaches 52-week high at 26.99 USD By Investing.com - Investing.com Canada

Nov 24, 2025
pulisher
Nov 24, 2025

Upstream Bio stock reaches 52-week high at 26.99 USD - Investing.com India

Nov 24, 2025
pulisher
Nov 21, 2025

Commit To Buy Upstream Bio At $20, Earn 80.2% Annualized Using Options - Nasdaq

Nov 21, 2025
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Nov 20, 2025

Why Upstream Bio Inc. stock is popular among millennialsEarnings Trend Report & Free Low Drawdown Momentum Trade Ideas - newser.com

Nov 20, 2025
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Nov 19, 2025

How strong is Upstream Bio Inc. stock revenue growthEarnings Miss & Stock Portfolio Risk Management - newser.com

Nov 19, 2025
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Nov 19, 2025

What risks investors should watch in Upstream Bio Inc. stock2025 Volatility Report & Growth-Oriented Investment Plans - newser.com

Nov 19, 2025
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Nov 19, 2025

Using data filters to optimize entry into Upstream Bio Inc.Earnings Recap Summary & Daily Stock Momentum Reports - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Top investors say Upstream Bio Inc (UPB) ticks everything they need - Setenews

Nov 19, 2025
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Nov 19, 2025

Evercore ISI Begins Coverage on Upstream Bio (NASDAQ:UPB) - MarketBeat

Nov 19, 2025
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Nov 19, 2025

Upstream Bio (NASDAQ:UPB) Now Covered by Evercore ISI - Defense World

Nov 19, 2025
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Nov 19, 2025

Upstream Bioprocessing Market on Track for Strong Growth, Estimated to Grow at 12.4% CAGR Through 2029 - openPR.com

Nov 19, 2025
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Nov 18, 2025

Analyzing Upstream Bio Inc. with multi timeframe chartsTrade Entry Report & Risk Adjusted Swing Trade Ideas - newser.com

Nov 18, 2025
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Nov 18, 2025

Upstream Bio, Inc.Common Stock (NQ: UPB - FinancialContent

Nov 18, 2025
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Nov 18, 2025

Evercore ISI Group Initiates Coverage of Upstream Bio (UPB) with Outperform Recommendation - Nasdaq

Nov 18, 2025
pulisher
Nov 18, 2025

Upstream Bio initiated with an Outperform at Evercore ISI - MSN

Nov 18, 2025
pulisher
Nov 18, 2025

Upstream Bio, Inc.’s Verekitug: A Promising Buy with Blockbuster Potential in Asthma and COPD Markets - TipRanks

Nov 18, 2025
pulisher
Nov 18, 2025

Why hedge funds are buying Upstream Bio Inc. stockTrade Analysis Summary & Verified Entry Point Detection - newser.com

Nov 18, 2025
pulisher
Nov 16, 2025

What earnings revisions data tells us about Upstream Bio Inc.2025 Price Momentum & Community Driven Trade Alerts - newser.com

Nov 16, 2025
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Nov 16, 2025

Ranking Upstream Bio Inc. among high performing stocks via toolsJuly 2025 Rallies & Daily Price Action Insights - newser.com

Nov 16, 2025
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Nov 16, 2025

Can momentum traders help lift Upstream Bio Inc.Earnings Risk Summary & Smart Investment Allocation Insights - newser.com

Nov 16, 2025
pulisher
Nov 16, 2025

Is Upstream Bio Inc. stock trading at a premium valuationEarnings Risk Summary & Smart Swing Trading Alerts - newser.com

Nov 16, 2025
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Nov 16, 2025

Can Upstream Bio Inc. stock resist sector downturnsShort Setup & Real-Time Volume Triggers - newser.com

Nov 16, 2025
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Nov 16, 2025

Candlestick signals on Upstream Bio Inc. stock todayPortfolio Gains Summary & Fast Exit Strategy with Risk Control - newser.com

Nov 16, 2025
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Nov 15, 2025

Is Upstream Bio Inc. stock dividend yield sustainable2025 Breakouts & Breakdowns & AI Forecast for Swing Trade Picks - newser.com

Nov 15, 2025

Upstream Bio Inc Stock (UPB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$38.39
price down icon 1.08%
$95.41
price down icon 0.72%
$31.31
price down icon 3.07%
$94.81
price down icon 1.24%
biotechnology ONC
$319.06
price down icon 0.55%
$197.01
price up icon 0.91%
Cap:     |  Volume (24h):