42.98
price down icon0.90%   -0.39
after-market After Hours: 42.98
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Ionis Pharmaceuticals Inc stock is traded at $42.98, with a volume of 3.54M. It is down -0.90% in the last 24 hours and up +8.78% over the past month. Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.
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Previous Close:
$43.37
Open:
$44.37
24h Volume:
3.54M
Relative Volume:
2.02
Market Cap:
$6.84B
Revenue:
$705.14M
Net Income/Loss:
$-453.90M
P/E Ratio:
-14.14
EPS:
-3.04
Net Cash Flow:
$-551.29M
1W Performance:
+1.97%
1M Performance:
+8.78%
6M Performance:
+34.73%
1Y Performance:
-13.10%
1-Day Range:
Value
$42.33
$44.98
1-Week Range:
Value
$40.81
$45.66
52-Week Range:
Value
$23.95
$51.62

Ionis Pharmaceuticals Inc Stock (IONS) Company Profile

Name
Name
Ionis Pharmaceuticals Inc
Name
Phone
(760) 931-9200
Name
Address
2855 GAZELLE COURT, CARLSBAD, CA
Name
Employee
927
Name
Twitter
@ionispharma
Name
Next Earnings Date
2024-11-06
Name
Latest SEC Filings
Name
IONS's Discussions on Twitter

Compare IONS with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
IONS
Ionis Pharmaceuticals Inc
42.98 6.90B 705.14M -453.90M -551.29M -3.04
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
456.87 120.48B 11.10B -988.90M -1.26B -3.92
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REGN
Regeneron Pharmaceuticals Inc
545.46 59.88B 14.09B 4.50B 2.96B 39.28
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ALNY
Alnylam Pharmaceuticals Inc
392.24 44.31B 2.35B -269.70M -75.39M -2.09
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ARGX
Argen X Se Adr
670.33 36.65B 2.58B 1.06B -1.28B 16.33
Biotechnology icon
ONC
Beone Medicines Ltd Adr
301.13 32.46B 3.81B -644.79M -669.77M -6.24

Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades

Date Action Analyst Rating Change
Jul-01-25 Upgrade Barclays Equal Weight → Overweight
Apr-07-25 Initiated H.C. Wainwright Buy
Mar-31-25 Initiated Redburn Atlantic Neutral
Aug-02-24 Downgrade BMO Capital Markets Outperform → Market Perform
Jul-24-24 Upgrade Leerink Partners Market Perform → Outperform
Jul-16-24 Resumed Jefferies Buy
Jun-14-24 Upgrade Bernstein Underperform → Mkt Perform
Apr-10-24 Upgrade Wolfe Research Peer Perform → Outperform
Jan-02-24 Upgrade BofA Securities Neutral → Buy
Oct-23-23 Upgrade BofA Securities Underperform → Neutral
Sep-29-23 Initiated Raymond James Strong Buy
Jul-31-23 Upgrade Citigroup Neutral → Buy
Jun-07-23 Resumed Piper Sandler Overweight
May-04-23 Upgrade Citigroup Sell → Neutral
Mar-21-23 Initiated Bernstein Underperform
Dec-21-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Sep-09-22 Resumed Morgan Stanley Overweight
Jul-18-22 Resumed Oppenheimer Outperform
Mar-31-22 Resumed Piper Sandler Overweight
Mar-01-22 Initiated Citigroup Sell
Mar-01-22 Initiated Guggenheim Buy
Feb-01-22 Downgrade BofA Securities Buy → Underperform
Dec-14-21 Upgrade William Blair Mkt Perform → Outperform
May-07-21 Upgrade UBS Sell → Neutral
Mar-01-21 Upgrade Barclays Underweight → Equal Weight
Dec-16-20 Initiated UBS Sell
Dec-15-20 Upgrade Cowen Market Perform → Outperform
Sep-14-20 Resumed JP Morgan Neutral
Sep-02-20 Initiated The Benchmark Company Hold
Jun-01-20 Resumed Oppenheimer Outperform
May-13-20 Initiated RBC Capital Mkts Outperform
Mar-05-20 Initiated Citigroup Buy
Dec-13-19 Initiated Oppenheimer Outperform
Nov-13-19 Initiated BofA/Merrill Buy
Nov-07-19 Downgrade Morgan Stanley Equal-Weight → Underweight
Sep-10-19 Upgrade Bernstein Mkt Perform → Outperform
Aug-08-18 Reiterated Stifel Hold
Aug-07-18 Reiterated Stifel Hold
May-08-18 Downgrade Evercore ISI Outperform → In-line
Oct-06-17 Resumed Goldman Sell
Aug-17-17 Initiated Evercore ISI Outperform
Aug-09-17 Reiterated Stifel Hold
Mar-10-17 Downgrade Goldman Neutral → Sell
Dec-28-16 Reiterated BMO Capital Markets Outperform
Dec-27-16 Reiterated Leerink Partners Mkt Perform
View All

Ionis Pharmaceuticals Inc Stock (IONS) Latest News

pulisher
Jul 31, 2025

Ionis Pharmaceuticals Reports Strong Earnings and Growth - TipRanks

Jul 31, 2025
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Jul 31, 2025

Ionis raises 2025 revenue guidance to $850M with Tryngolza momentum and Donidalorsen launch on track - MSN

Jul 31, 2025
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Jul 31, 2025

How does Ionis Pharmaceuticals Inc. compare to its industry peersAI Powered Tips With High Returns - jammulinksnews.com

Jul 31, 2025
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Jul 31, 2025

Ionis (IONS) Q2 Revenue Soars 101% - The Globe and Mail

Jul 31, 2025
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Jul 31, 2025

UK Approves Biogen’s Qalsody After England Revises Reimbursement Approach - insights.citeline.com

Jul 31, 2025
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Jul 31, 2025

Ionis Beats on Q2 Earnings & Sales, Stock Up 5% on Raised '25 Outlook - TradingView

Jul 31, 2025
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Jul 31, 2025

Ionis Pharmaceuticals stock price target raised to $65 from $50 at H.C. Wainwright - Investing.com Canada

Jul 31, 2025
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Jul 31, 2025

Ionis reports second quarter 2025 financial results and highlights progress on key programs - BioSpace

Jul 31, 2025
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Jul 31, 2025

Ionis Pharmaceuticals Inc (IONS) Q2 2025 Earnings Call Highlights: Revenue Surge and Strategic ... - Yahoo Finance

Jul 31, 2025
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Jul 31, 2025

Ionis Pharmaceuticals Reports Strong Q2 2025 Results - TipRanks

Jul 31, 2025
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Jul 30, 2025

Morgan Stanley upgrades Ionis Pharmaceuticals stock rating on strong Tryngolza launch - Investing.com India

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals' 2025 Q2 Earnings: A Launch-Driven Growth Story with Multi-Billion-Dollar Potential - AInvest

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals, Inc. 2025 Q2ResultsEarnings Call Presentation (NASDAQ:IONS) - Seeking Alpha

Jul 30, 2025
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Jul 30, 2025

Earnings call transcript: Ionis Pharmaceuticals Q2 2025 Surpasses Revenue Expectations - Investing.com Australia

Jul 30, 2025
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Jul 30, 2025

Ionis (IONS) Q2 2025 Earnings Call Transcript - AOL.com

Jul 30, 2025
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Jul 30, 2025

Why Ionis Pharmaceuticals Shares Are Up After Q2 ReportIonis Pharmaceuticals (NASDAQ:IONS) - Benzinga

Jul 30, 2025
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Jul 30, 2025

Ionis Q2 2025 slides: TRYNGOLZA sales surge as pipeline advances By Investing.com - Investing.com Canada

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals Reports Strong Q2 2025 Financial Results - TradingView

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals' Q2 Outperformance and Strategic Pipeline Catalysts: A High-Conviction Buy Before Earnings Release? - AInvest

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals Inc reports results for the quarter ended June 30Earnings Summary - TradingView

Jul 30, 2025
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Jul 30, 2025

Here's What Key Metrics Tell Us About Ionis Pharmaceuticals (IONS) Q2 Earnings - Yahoo Finance

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals: Q2 Earnings Snapshot - The Washington Post

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals Inc. May Be Forming Higher Low — Chartwatchers AlertStock Market Entry Timing Signals Revealed - metal.it

Jul 30, 2025
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Jul 30, 2025

Ionis Pharmaceuticals (IONS) Q2 Earnings and Revenues Beat Estimates - Yahoo Finance

Jul 30, 2025
pulisher
Jul 30, 2025

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Too Much Debt? - simplywall.st

Jul 30, 2025
pulisher
Jul 29, 2025

Ionis Pharmaceuticals (IONS) Received Positive Opinion from European Medicines Agency - Insider Monkey

Jul 29, 2025
pulisher
Jul 28, 2025

What is the dividend policy of Ionis Pharmaceuticals Inc. stockTop Growth Entry Points To Watch Now - jammulinksnews.com

Jul 28, 2025
pulisher
Jul 28, 2025

What makes Ionis Pharmaceuticals Inc. stock price move sharplyDiscover stocks with superior performance - jammulinksnews.com

Jul 28, 2025
pulisher
Jul 28, 2025

Has Ionis Pharmaceuticals Inc. Stock Ever Crashed Historical Volatility Review Free Weekly Return Pick Forecast Reports - metal.it

Jul 28, 2025
pulisher
Jul 28, 2025

Is it the right time to buy Ionis Pharmaceuticals Inc. stockOutstanding trading profits - jammulinksnews.com

Jul 28, 2025
pulisher
Jul 28, 2025

Ionis Pharmaceuticals IONS 2025Q2 Earnings Preview Upside Potential on Revenue Growth - AInvest

Jul 28, 2025
pulisher
Jul 28, 2025

Why is Ionis Pharmaceuticals Inc. stock attracting strong analyst attentionGet timely alerts on market opportunities - jammulinksnews.com

Jul 28, 2025
pulisher
Jul 28, 2025

What is the risk reward ratio of investing in Ionis Pharmaceuticals Inc. stockAchieve consistent double-digit returns - jammulinksnews.com

Jul 28, 2025
pulisher
Jul 27, 2025

What are analysts’ price targets for Ionis Pharmaceuticals Inc. in the next 12 monthsStay ahead with daily expert stock picks - jammulinksnews.com

Jul 27, 2025
pulisher
Jul 27, 2025

Does Ionis Pharmaceuticals Inc. stock perform well during market downturnsSuperior return velocity - jammulinksnews.com

Jul 27, 2025
pulisher
Jul 27, 2025

What institutional investors are buying Ionis Pharmaceuticals Inc. stockInvest in stocks with strong fundamentals - jammulinksnews.com

Jul 27, 2025
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Jul 27, 2025

When is Ionis Pharmaceuticals Inc. stock expected to show significant growthConsistently outstanding ROI - jammulinksnews.com

Jul 27, 2025
pulisher
Jul 26, 2025

Ionis Pharmaceuticals Announces Positive Donidalorsen Results for Hereditary Angioedema Published in JACI In Practice - MSN

Jul 26, 2025
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Jul 25, 2025

Is Ionis Pharmaceuticals (NASDAQ:IONS) Using Debt Sensibly? - 富途牛牛

Jul 25, 2025
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Jul 25, 2025

Ionis Pharmaceuticals Gains CHMP Approval for Tryngolza: Analysts Project 36.63% Upside - AInvest

Jul 25, 2025
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Jul 25, 2025

Ionis Pharmaceuticals Inc. Stock Analysis and ForecastFree Stock Market Real-Time Monitoring - PrintWeekIndia

Jul 25, 2025
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Jul 25, 2025

KalVista, Biogen, Ionis get EU positive opinions for key drugs (KALV:NASDAQ) - Seeking Alpha

Jul 25, 2025
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Jul 25, 2025

Gene Therapy Partnerships: Sobi and Ionis Pharmaceuticals' Olezarsen and the EU Market Opportunity - AInvest

Jul 25, 2025
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Jul 25, 2025

Is Ionis Pharmaceuticals Inc. a good long term investmentBreakthrough capital growth - Autocar Professional

Jul 25, 2025
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Jul 25, 2025

TRYNGOLZA® (olezarsen) recommended for EU approval by CHMP for familial chylomicronemia syndrome (FCS) - Yahoo Finance

Jul 25, 2025
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Jul 25, 2025

TRYNGOLZA® (olezarsen) recommended for approval in the EU by CHMP for familial chylomicronemia syndrome (FCS) - Business Wire

Jul 25, 2025
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Jul 23, 2025

10 Best Mid Cap Pharma Stocks to Buy - Insider Monkey

Jul 23, 2025
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Jul 23, 2025

Ionis Pharmaceuticals (IONS) Earnings Expected to Grow: Should You Buy? - Yahoo.co

Jul 23, 2025
pulisher
Jul 23, 2025

Ionis Pharmaceuticals founder Stanley Crooke on the fight against rare diseases - MSN

Jul 23, 2025
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Jul 23, 2025

What analysts say about Ionis Pharmaceuticals Inc. stockRapid portfolio appreciation - Autocar Professional

Jul 23, 2025

Ionis Pharmaceuticals Inc Stock (IONS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$74.89
price down icon 3.43%
$36.80
price down icon 0.86%
$107.28
price up icon 2.00%
$26.37
price down icon 1.09%
$107.50
price down icon 2.32%
biotechnology ONC
$301.13
price up icon 0.40%
Cap:     |  Volume (24h):