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43.81
0.27%
-0.12
Pre-market:
44.00
0.19
+0.43%
Ionis Pharmaceuticals Inc stock is traded at $43.81, with a volume of 5.49M.
It is down -0.27% in the last 24 hours and down -29.38% over the past month.
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
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Previous Close:
$43.93
Open:
$43.77
24h Volume:
5.49M
Relative Volume:
1.54
Market Cap:
$7.28B
Revenue:
$1.06B
Net Income/Loss:
$-326.58M
P/E Ratio:
-20.84
EPS:
-2.1022
Net Cash Flow:
$-977.73M
1W Performance:
-6.29%
1M Performance:
-29.38%
6M Performance:
-37.13%
1Y Performance:
-31.48%
1-Day Range:
$43.25
$44.60
1-Week Range:
$43.01
$46.75
52-Week Range:
$43.01
$86.74
Ionis Pharmaceuticals Inc Stock (IONS) Company Profile
Name
Ionis Pharmaceuticals Inc
Sector
Industry
Phone
(760) 931-9200
Address
2855 GAZELLE COURT, CARLSBAD, CA
Compare IONS vs VRTX, REGN, MRNA, ARGX, RVMD
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
IONS
Ionis Pharmaceuticals Inc
|
43.81 | 7.28B | 1.06B | -326.58M | -977.73M | -2.1022 |
VRTX
Vertex Pharmaceuticals Inc
|
522.38 | 132.40B | 12.34B | 4.34B | 3.71B | 16.87 |
REGN
Regeneron Pharmaceuticals Inc
|
796.02 | 81.95B | 14.92B | 4.42B | 3.79B | 41.04 |
MRNA
Moderna Inc
|
194.82 | 77.78B | 2.23B | -3.19B | -1.60B | -8.1462 |
ARGX
Argen X Se Adr
|
962.22 | 60.20B | 4.16B | 1.29B | 734.26M | 19.58 |
RVMD
Revolution Medicines Inc
|
199.86 | 42.84B | 742.00K | -1.37B | -1.07B | -7.0731 |
Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Apr-21-26 | Initiated | Canaccord Genuity | Buy |
| Apr-10-26 | Resumed | Raymond James | Outperform |
| Jan-28-26 | Resumed | Barclays | Overweight |
| Oct-08-25 | Upgrade | JP Morgan | Neutral → Overweight |
| Sep-26-25 | Upgrade | Goldman | Sell → Neutral |
| Sep-03-25 | Upgrade | BMO Capital Markets | Market Perform → Outperform |
| Jul-31-25 | Upgrade | Morgan Stanley | Equal-Weight → Overweight |
| Jul-01-25 | Upgrade | Barclays | Equal Weight → Overweight |
| Apr-07-25 | Initiated | H.C. Wainwright | Buy |
| Mar-31-25 | Initiated | Redburn Atlantic | Neutral |
| Aug-02-24 | Downgrade | BMO Capital Markets | Outperform → Market Perform |
| Jul-24-24 | Upgrade | Leerink Partners | Market Perform → Outperform |
| Jul-16-24 | Resumed | Jefferies | Buy |
| Jun-14-24 | Upgrade | Bernstein | Underperform → Mkt Perform |
| Apr-10-24 | Upgrade | Wolfe Research | Peer Perform → Outperform |
| Jan-02-24 | Upgrade | BofA Securities | Neutral → Buy |
| Oct-23-23 | Upgrade | BofA Securities | Underperform → Neutral |
| Sep-29-23 | Initiated | Raymond James | Strong Buy |
| Jul-31-23 | Upgrade | Citigroup | Neutral → Buy |
| Jun-07-23 | Resumed | Piper Sandler | Overweight |
| May-04-23 | Upgrade | Citigroup | Sell → Neutral |
| Mar-21-23 | Initiated | Bernstein | Underperform |
| Dec-21-22 | Downgrade | Morgan Stanley | Overweight → Equal-Weight |
| Sep-09-22 | Resumed | Morgan Stanley | Overweight |
| Jul-18-22 | Resumed | Oppenheimer | Outperform |
| Mar-31-22 | Resumed | Piper Sandler | Overweight |
| Mar-01-22 | Initiated | Citigroup | Sell |
| Mar-01-22 | Initiated | Guggenheim | Buy |
| Feb-01-22 | Downgrade | BofA Securities | Buy → Underperform |
| Dec-14-21 | Upgrade | William Blair | Mkt Perform → Outperform |
| May-07-21 | Upgrade | UBS | Sell → Neutral |
| Mar-01-21 | Upgrade | Barclays | Underweight → Equal Weight |
| Dec-16-20 | Initiated | UBS | Sell |
| Dec-15-20 | Upgrade | Cowen | Market Perform → Outperform |
| Sep-14-20 | Resumed | JP Morgan | Neutral |
| Sep-02-20 | Initiated | The Benchmark Company | Hold |
| Jun-01-20 | Resumed | Oppenheimer | Outperform |
| May-13-20 | Initiated | RBC Capital Mkts | Outperform |
| Mar-05-20 | Initiated | Citigroup | Buy |
| Dec-13-19 | Initiated | Oppenheimer | Outperform |
| Nov-13-19 | Initiated | BofA/Merrill | Buy |
| Nov-07-19 | Downgrade | Morgan Stanley | Equal-Weight → Underweight |
| Sep-10-19 | Upgrade | Bernstein | Mkt Perform → Outperform |
| Aug-08-18 | Reiterated | Stifel | Hold |
| Aug-07-18 | Reiterated | Stifel | Hold |
| May-08-18 | Downgrade | Evercore ISI | Outperform → In-line |
| Oct-06-17 | Resumed | Goldman | Sell |
| Aug-17-17 | Initiated | Evercore ISI | Outperform |
| Aug-09-17 | Reiterated | Stifel | Hold |
| Mar-10-17 | Downgrade | Goldman | Neutral → Sell |
| Dec-28-16 | Reiterated | BMO Capital Markets | Outperform |
| Dec-27-16 | Reiterated | Leerink Partners | Mkt Perform |
View All
Ionis Pharmaceuticals Inc Stock (IONS) Latest News
Ionis Pharmaceuticals (IONS) Stock Looks Pricey On Its 45% YTD Slide - Yahoo Finance
Analysts Offer Insights on Healthcare Companies: Immunovant (IMVT) and Ionis Pharmaceuticals (IONS) - The Globe and Mail
Failure of Novartis’ Pelacarsen Could Reshape the Lp(a) Race for CRISPR and Ionis - Yahoo Finance
H.C. Wainwright reiterates Ionis Pharmaceuticals stock rating on trial data By Investing.com - Investing.com Canada
H.C. Wainwright reiterates Ionis Pharmaceuticals stock rating on trial data - Investing.com
Canaccord Genuity Remains a Buy on Ionis Pharmaceuticals (IONS) - The Globe and Mail
Oppenheimer reiterates Ionis stock rating on late-stage wins By Investing.com - Investing.com Canada
Ionis Pharmaceuticals, Inc. (IONS) Options ChainYahoo Finance - Yahoo! Finance Canada
Otsuka, Ionis notch phase III win in FUS-ALS - BioWorld News
IONIS Pharmaceuticals (NASDAQ: IONS) Announces Positive Interim Phase 3 Data for Sefaxersen in IgA Nephropathy - Kalkine Media
Ionis Pharmaceuticals and Roche Announce Positive Phase 3 Interim Results for Sefaxersen in IgA Nephropathy - Kalkine Media
Ionis Delivers Positive Late-Stage Results for Two Partnered Drugs - Zacks Investment Research
Roche, Ionis RNA drug scores in kidney disease study - BioPharma Dive
IONS Looks 5.2% Undervalued on GF Value™ Amid RNA Therapy Trial News - gurufocus.com
Ionis Pharmaceuticals' Phase 3 kidney trial meets proteinuria endpoint - Mugglehead Investment Magazine
Otsuka, Ionis to Discuss Approval Path for FUS-ALS Drug With Regulators - GenomeWeb
Ionis Pharmaceuticals stock hits 52-week low at $44.20 By Investing.com - Investing.com India
BMO reiterates Ionis Pharmaceuticals stock rating on ALS drug data By Investing.com - Investing.com Canada
Roche, Ionis post trial win for kidney drug (IONS:NASDAQ) - Seeking Alpha
Ionis and Roche Advance First RNA-Targeted Therapy for Autoimmune Kidney Disease - Benzinga
Form 8K IONIS PHARMACEUTICALS For: 23 September By Investing.com - Investing.com Nigeria
Canaccord reiterates Ionis stock rating on positive trial results By Investing.com - Investing.com Canada
Ionis reports positive Phase 3 interim results for sefaxersen in IgA nephropathy - TradingView
Otsuka and Ionis report positive data in Phase III FUSION trial of ulefnersen - Yahoo
Otsuka and Ionis report positive Phase III readout for ulefnersen - The Pharma Letter
Ionis announces positive interim data from partner Roche’s Phase 3 IMAgINATION study in IgA nephropathy (IgAN) - BioSpace
Ionis, Roche report positive phase 3 data for kidney drug - Investing.com
Ionis, Roche report positive phase 3 data for kidney drug By Investing.com - Investing.com Australia
IONS Looks 7.0% Undervalued on GF Value™ - gurufocus.com
Ionis to Seek Expedited FDA Review for ALS Drug - Benzinga
IONS Looks 7.2% Undervalued on GF Value™ Amid Mixed Growth and P - gurufocus.com
Cathie Wood Loads Up On Biotech: 5 ETFs Holding Her Latest Bets - TradingView
Otsuka, Ionis’ experimental ALS drug meets main goal in late-stage study - 101 WIXX
JPMorgan cuts Ionis Pharmaceuticals stock price target on launch concerns By Investing.com - Investing.com UK
Ionis drug meets primary goal in rare ALS gene mutation trial - Investing.com Canada
Ionis drug meets primary goal in rare ALS gene mutation trial By Investing.com - Investing.com South Africa
Ionis Pharmaceuticals Says Ulefnersen Demonstrates Favorable Safety And Tolerability Profile - TradingView
Ionis Pharmaceuticals Price Target Cut to $70.00/Share From $76.00 by JP Morgan - Moomoo
Ionis announces positive topline results from Phase 3 FUSION study of ulefnersen marking significant milestone in advancing first potential disease modifying treatment for FUS-ALS - Yahoo Finance
(IONS) Movement Within Algorithmic Entry Frameworks - Stock Traders Daily
High Growth Tech Stocks To Watch In The US September 2026 - simplywall.st
Ionis Pharmaceuticals, Inc. (IONS): Investor Outlook On An 88.61% Potential Upside - DirectorsTalk Interviews
Investors Dumped Ionis Pharmaceuticals Stock -- But Wall Street Hasn't Budged From Its Bullish Outlook - Yahoo Finance
Investors Dumped Ionis Pharmaceuticals Stock -- But Wall Street Hasn't Budged From Its Bullish Outlook - The Motley Fool
Ionis Pharmaceuticals Stock Plummets Yet Analysts Remain Optimistic - intellectia.ai
Ionis Pharmaceuticals Eyes TRYNGOLZA Growth as Pipeline Faces Cardio Setbacks - Yahoo Finance
Ionis Pharmaceuticals (IONS) Dropped, What Is Behind The Latest Attention? - Yahoo Finance
IONS Looks 6.5% Undervalued on GF Value™ Despite Challenging Fun - GuruFocus
Ionis (IONS) Stock Looks Fully Valued As A Phase 3 Trial Miss Lands - simplywall.st
Novartis (NVS) and Ionis (IONS)’ Big Cholesterol Bet Comes Up Short in Late-Stage Trial - Yahoo Finance
Ionis Pharmaceuticals Stock Slides 27% Over 9 Straight Down Days - Trefis
Ionis Pharmaceuticals Inc Stock (IONS) Financials Data
Revenue
Net Income
Cash Flow
EPS
1.11%
1.87%
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