63.16
price down icon1.37%   -0.88
after-market After Hours: 63.16
loading
Ionis Pharmaceuticals Inc stock is traded at $63.16, with a volume of 1.42M. It is down -1.37% in the last 24 hours and up +52.52% over the past month. Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.
See More
Previous Close:
$64.04
Open:
$63.85
24h Volume:
1.42M
Relative Volume:
0.60
Market Cap:
$10.07B
Revenue:
$705.14M
Net Income/Loss:
$-453.90M
P/E Ratio:
-20.78
EPS:
-3.04
Net Cash Flow:
$-551.29M
1W Performance:
+3.15%
1M Performance:
+52.52%
6M Performance:
+89.05%
1Y Performance:
+53.97%
1-Day Range:
Value
$63.07
$64.61
1-Week Range:
Value
$59.36
$64.72
52-Week Range:
Value
$23.95
$64.72

Ionis Pharmaceuticals Inc Stock (IONS) Company Profile

Name
Name
Ionis Pharmaceuticals Inc
Name
Phone
(760) 931-9200
Name
Address
2855 GAZELLE COURT, CARLSBAD, CA
Name
Employee
927
Name
Twitter
@ionispharma
Name
Next Earnings Date
2024-11-06
Name
Latest SEC Filings
Name
IONS's Discussions on Twitter

Compare IONS with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
IONS
Ionis Pharmaceuticals Inc
63.16 10.20B 705.14M -453.90M -551.29M -3.04
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
394.53 99.62B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
465.89 61.52B 2.46B -319.09M -52.09M -2.47
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
560.00 58.91B 14.21B 4.46B 3.56B 39.68
Biotechnology icon
ARGX
Argen X Se Adr
756.38 46.69B 3.06B 1.28B 447.35M 21.30
Biotechnology icon
ONC
Beone Medicines Ltd Adr
324.34 34.54B 3.81B -644.79M -669.77M -6.24

Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades

Date Action Analyst Rating Change
Sep-03-25 Upgrade BMO Capital Markets Market Perform → Outperform
Jul-31-25 Upgrade Morgan Stanley Equal-Weight → Overweight
Jul-01-25 Upgrade Barclays Equal Weight → Overweight
Apr-07-25 Initiated H.C. Wainwright Buy
Mar-31-25 Initiated Redburn Atlantic Neutral
Aug-02-24 Downgrade BMO Capital Markets Outperform → Market Perform
Jul-24-24 Upgrade Leerink Partners Market Perform → Outperform
Jul-16-24 Resumed Jefferies Buy
Jun-14-24 Upgrade Bernstein Underperform → Mkt Perform
Apr-10-24 Upgrade Wolfe Research Peer Perform → Outperform
Jan-02-24 Upgrade BofA Securities Neutral → Buy
Oct-23-23 Upgrade BofA Securities Underperform → Neutral
Sep-29-23 Initiated Raymond James Strong Buy
Jul-31-23 Upgrade Citigroup Neutral → Buy
Jun-07-23 Resumed Piper Sandler Overweight
May-04-23 Upgrade Citigroup Sell → Neutral
Mar-21-23 Initiated Bernstein Underperform
Dec-21-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Sep-09-22 Resumed Morgan Stanley Overweight
Jul-18-22 Resumed Oppenheimer Outperform
Mar-31-22 Resumed Piper Sandler Overweight
Mar-01-22 Initiated Citigroup Sell
Mar-01-22 Initiated Guggenheim Buy
Feb-01-22 Downgrade BofA Securities Buy → Underperform
Dec-14-21 Upgrade William Blair Mkt Perform → Outperform
May-07-21 Upgrade UBS Sell → Neutral
Mar-01-21 Upgrade Barclays Underweight → Equal Weight
Dec-16-20 Initiated UBS Sell
Dec-15-20 Upgrade Cowen Market Perform → Outperform
Sep-14-20 Resumed JP Morgan Neutral
Sep-02-20 Initiated The Benchmark Company Hold
Jun-01-20 Resumed Oppenheimer Outperform
May-13-20 Initiated RBC Capital Mkts Outperform
Mar-05-20 Initiated Citigroup Buy
Dec-13-19 Initiated Oppenheimer Outperform
Nov-13-19 Initiated BofA/Merrill Buy
Nov-07-19 Downgrade Morgan Stanley Equal-Weight → Underweight
Sep-10-19 Upgrade Bernstein Mkt Perform → Outperform
Aug-08-18 Reiterated Stifel Hold
Aug-07-18 Reiterated Stifel Hold
May-08-18 Downgrade Evercore ISI Outperform → In-line
Oct-06-17 Resumed Goldman Sell
Aug-17-17 Initiated Evercore ISI Outperform
Aug-09-17 Reiterated Stifel Hold
Mar-10-17 Downgrade Goldman Neutral → Sell
Dec-28-16 Reiterated BMO Capital Markets Outperform
Dec-27-16 Reiterated Leerink Partners Mkt Perform
View All

Ionis Pharmaceuticals Inc Stock (IONS) Latest News

pulisher
Sep 12, 2025

Ionis pharmaceuticals celebrates 10 years of adaptive event for rare diseases - Investing.com

Sep 12, 2025
pulisher
Sep 12, 2025

Ionis expands Surf Away+ event, marking 10 years of creating unique adaptive experiences for people with neurological diseases - Yahoo Finance

Sep 12, 2025
pulisher
Sep 11, 2025

Ionis gets FDA breakthrough therapy status for angelman syndrome drug - MSN

Sep 11, 2025
pulisher
Sep 11, 2025

Insider Selling: Ionis Pharmaceuticals (NASDAQ:IONS) EVP Sells 6,000 Shares of Stock - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Ionis, Arrowhead file dueling patent lawsuits over genetic-disorder drug - Reuters

Sep 11, 2025
pulisher
Sep 11, 2025

Raymond James Financial Inc. Boosts Stock Position in Ionis Pharmaceuticals, Inc. $IONS - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Arrowhead, Ionis Sue Each Other Over Rare Fat Disorder Drugs - Bloomberg Law News

Sep 11, 2025
pulisher
Sep 11, 2025

Arrowhead sues Ionis over patent dispute related to lead asset - Seeking Alpha

Sep 11, 2025
pulisher
Sep 11, 2025

IONS Up on FDA's Breakthrough Tag for ION582 in Angelman Syndrome - MSN

Sep 11, 2025
pulisher
Sep 11, 2025

Ionis Pharmaceuticals (NASDAQ:IONS) Sets New 1-Year HighStill a Buy? - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Arrowhead Pharmaceuticals Files Complaint for Declaratory Judgment Against Ionis Pharmaceuticals - Business Wire

Sep 11, 2025
pulisher
Sep 11, 2025

Edmond DE Rothschild Holding S.A. Takes Position in Ionis Pharmaceuticals, Inc. $IONS - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Ionis Pharmaceuticals, Inc. $IONS Stock Holdings Raised by Exome Asset Management LLC - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Ionis Stock: Renewed Assault On $100.00 Per Share (NASDAQ:IONS) - Seeking Alpha

Sep 11, 2025
pulisher
Sep 10, 2025

Adage Capital Partners GP L.L.C. Purchases 800,600 Shares of Ionis Pharmaceuticals, Inc. $IONS - MarketBeat

Sep 10, 2025
pulisher
Sep 10, 2025

Royal Bank Of Canada Forecasts Strong Price Appreciation for Ionis Pharmaceuticals (NASDAQ:IONS) Stock - MarketBeat

Sep 10, 2025
pulisher
Sep 09, 2025

Ionis pharma EVP Bennett sells $357k in IONS stock By Investing.com - Investing.com UK

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis Pharmaceuticals at Morgan Stanley Conference: Strategic Growth and Innovation - Investing.com Canada

Sep 09, 2025
pulisher
Sep 09, 2025

FDA Grants Breakthrough Therapy Designation to Ionis (IONS) Drug - GuruFocus

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis Pharmaceuticals stock hits 52-week high at 62.28 USD By Investing.com - Investing.com Canada

Sep 09, 2025
pulisher
Sep 09, 2025

Aug Volume: Can Ionis Pharmaceuticals Inc. be recession proofMarket Rally & Capital Efficiency Focused Ideas - Lancaster City Council

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis Rare Neurological Disease Candidate Receives FDA Breakthrough StatusIonis Pharmaceuticals (NASDAQ:IONS) - Benzinga

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis Pharmaceuticals stock hits 52-week high at 62.28 USD - Investing.com

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis announces pricing of $500.3 million public offering - MSN

Sep 09, 2025
pulisher
Sep 09, 2025

Health Stocks Shift As UnitedHealth Rises And PACS Drops - Finimize

Sep 09, 2025
pulisher
Sep 09, 2025

FDA Grants Breakthrough Therapy Status to Ionis Pharmaceuticals' ION582 - GuruFocus

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis receives U.S. FDA Breakthrough Therapy designation for ION582 in Angelman syndrome - Business Wire

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis Pharmaceuticals (NASDAQ:IONS) Sees Strong Trading Volume on Analyst Upgrade - MarketBeat

Sep 09, 2025
pulisher
Sep 09, 2025

Ionis to host investors and analysts for Innovation Day 2025 - BioSpace

Sep 09, 2025
pulisher
Sep 08, 2025

Ionis Pharmaceuticals at H.C. Wainwright: Strategic Pipeline Advancements By Investing.com - Investing.com Canada

Sep 08, 2025
pulisher
Sep 08, 2025

Ionis to host investors and analysts for Innovation Day 2025 | I - GuruFocus

Sep 08, 2025
pulisher
Sep 08, 2025

Ionis Pharmaceuticals (IONS) Is Up 43.6% After Positive Phase 3 Olezarsen Results in Severe Hypertriglyceridemia – Has the Bull Case Changed? - Yahoo Finance

Sep 08, 2025
pulisher
Sep 08, 2025

Ionis Pharmaceuticals (NASDAQ:IONS) Given New $45.00 Price Target at The Goldman Sachs Group - MarketBeat

Sep 08, 2025
pulisher
Sep 08, 2025

What are Ionis Pharmaceuticals Inc.’s earnings expectationsTrade Signal Summary & High Accuracy Investment Entry Signals - beatles.ru

Sep 08, 2025
pulisher
Sep 07, 2025

Ionis upgraded at BMO Capital Markets after data for lipid-lowering agent - MSN

Sep 07, 2025
pulisher
Sep 07, 2025

Ionis Pharmaceuticals (NASDAQ:IONS) Given New $96.00 Price Target at Jefferies Financial Group - MarketBeat

Sep 07, 2025
pulisher
Sep 06, 2025

HC Wainwright Issues Positive Forecast for Ionis Pharmaceuticals (NASDAQ:IONS) Stock Price - MarketBeat

Sep 06, 2025
pulisher
Sep 06, 2025

Does Ionis Pharmaceuticals Inc. stock have upside surprise potentialQuarterly Growth Report & Expert-Curated Trade Recommendations - خودرو بانک

Sep 06, 2025
pulisher
Sep 06, 2025

Ionis Pharma director Loscalzo sells $962k in shares By Investing.com - Investing.com Australia

Sep 06, 2025
pulisher
Sep 06, 2025

What are analysts’ price targets for Ionis Pharmaceuticals Inc.2025 Key Lessons & Precise Buy Zone Tips - خودرو بانک

Sep 06, 2025
pulisher
Sep 05, 2025

Ionis Pharma EVP Baroldi sells $1.95m in shares By Investing.com - Investing.com Australia

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis Pharmaceuticals director Wender sells $1.6m in shares By Investing.com - Investing.com South Africa

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis pharma EVP Devers sells $192,942 in IONS stock By Investing.com - Investing.com South Africa

Sep 05, 2025
pulisher
Sep 05, 2025

Is Ionis Pharmaceuticals Inc. a potential multi baggerJuly 2025 Price Swings & Long-Term Safe Return Strategies - خودرو بانک

Sep 05, 2025
pulisher
Sep 05, 2025

What is the earnings history of Ionis Pharmaceuticals Inc.Quarterly Profit Report & Smart Swing Trading Techniques - خودرو بانک

Sep 05, 2025
pulisher
Sep 05, 2025

Biotech Premarket Movers: ChemoCentryx, Jazz, Ionis, Zogenix - TheStreet

Sep 05, 2025
pulisher
Sep 05, 2025

How sentiment analysis helps forecast Ionis Pharmaceuticals Inc.Portfolio Value Summary & AI Based Buy/Sell Signal Reports - Newser

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis Pharmaceuticals Stock (IONS) Opinions on Olezarsen Trial Results and FDA Approval - Quiver Quantitative

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis pharma EVP O’Neil sells $5.39 million in IONS stock - Investing.com Nigeria

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) 38% Price Boost Is Out Of Tune With Revenues - 富途牛牛

Sep 05, 2025
pulisher
Sep 05, 2025

Ionis Pharma EVP Schneider sells $1.19m in shares By Investing.com - Investing.com Nigeria

Sep 05, 2025

Ionis Pharmaceuticals Inc Stock (IONS) Financials Data

Revenue

loading

Net Income

loading

Cash Flow

loading

EPS

loading
$36.36
price down icon 0.93%
$83.10
price down icon 3.56%
$27.82
price down icon 2.76%
$96.74
price down icon 7.26%
$145.93
price up icon 0.10%
biotechnology ONC
$324.34
price down icon 3.38%
Cap:     |  Volume (24h):