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68.99
7.78%
4.98
After Hours:
69.02
0.03
+0.04%
Spyre Therapeutics Inc stock is traded at $68.99, with a volume of 4.20M.
It is up +7.78% in the last 24 hours and up +72.95% over the past month.
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$64.01
Open:
$67.75
24h Volume:
4.20M
Relative Volume:
4.83
Market Cap:
$5.44B
Revenue:
$688.00K
Net Income/Loss:
$-135.82M
P/E Ratio:
-33.20
EPS:
-2.078
Net Cash Flow:
$-169.41M
1W Performance:
+32.72%
1M Performance:
+72.95%
6M Performance:
+210.91%
1Y Performance:
+442.80%
1-Day Range:
$64.60
$69.45
1-Week Range:
$50.85
$75.00
52-Week Range:
$12.04
$75.00
Spyre Therapeutics Inc Stock (SYRE) Company Profile
Name
Spyre Therapeutics Inc
Sector
Industry
Phone
(617) 651-5940
Address
221 CRESCENT STREET, WALTHAM
Compare SYRE vs VRTX, REGN, ARGX, ALNY, ONC
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
SYRE
Spyre Therapeutics Inc
|
68.99 | 5.04B | 688.00K | -135.82M | -169.41M | -2.078 |
VRTX
Vertex Pharmaceuticals Inc
|
441.70 | 113.01B | 12.07B | 3.95B | 3.19B | 15.33 |
REGN
Regeneron Pharmaceuticals Inc
|
753.93 | 79.87B | 14.34B | 4.50B | 3.77B | 41.56 |
ARGX
Argen X Se Adr
|
840.87 | 51.51B | 4.16B | 1.29B | 734.26M | 19.58 |
ALNY
Alnylam Pharmaceuticals Inc
|
333.39 | 45.29B | 3.71B | 313.75M | 465.38M | 2.2571 |
ONC
Beone Medicines Ltd Adr
|
319.94 | 34.41B | 5.36B | 287.73M | 924.18M | 2.5229 |
Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Dec-18-25 | Initiated | Mizuho | Outperform |
| Dec-17-25 | Initiated | Citigroup | Buy |
| Sep-26-25 | Initiated | Deutsche Bank | Buy |
| Apr-08-25 | Initiated | Leerink Partners | Outperform |
| Mar-18-25 | Initiated | Wolfe Research | Outperform |
| Sep-04-24 | Initiated | Wedbush | Outperform |
| Jul-16-24 | Initiated | Evercore ISI | Outperform |
| May-02-24 | Initiated | Robert W. Baird | Outperform |
| Mar-01-24 | Upgrade | Wells Fargo | Equal Weight → Overweight |
| Dec-20-23 | Initiated | BTIG Research | Buy |
| Dec-11-23 | Initiated | Guggenheim | Buy |
| Dec-11-23 | Initiated | Jefferies | Buy |
| May-04-20 | Initiated | Piper Sandler | Overweight |
| Mar-21-19 | Initiated | JP Morgan | Overweight |
| Sep-04-18 | Downgrade | Wells Fargo | Outperform → Market Perform |
| Apr-24-18 | Initiated | Evercore ISI | Outperform |
| Mar-14-18 | Reiterated | Needham | Buy |
View All
Spyre Therapeutics Inc Stock (SYRE) Latest News
Spyre Therapeutics prices upsized $403M stock deal; gross proceeds exceed initial $300M goal - MSN
SYRE Secures $403M Common Stock Offering - GuruFocus
Spyre Therapeutics Announces $403M Public Offering - National Today
SYRE Maintained by Deutsche Bank -- Price Target Raised to $88 - GuruFocus
Spyre Therapeutics prices $403M public stock offering at $62 - Investing.com
Spyre Therapeutics announces pricing of upsized $403 million public offering of common stock - marketscreener.com
Spyre Therapeutics Announces $403 Million Public Offering of Common Stock - Quiver Quantitative
Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock - GlobeNewswire Inc.
SYRE Maintained by Wedbush -- Price Target Raised to $80.00 - GuruFocus
SYRE Maintained by Baird -- Price Target Raised to $90.00 - GuruFocus
Spyre Therapeutics launches $300 million stock offering By Investing.com - Investing.com Australia
SYRE Initiated Coverage by Raymond James -- Strong Buy Rating As - GuruFocus
Mizuho Boosts Price Target on Spyre Therapeutics to $84 From $53, Keeps Outperform Rating - Moomoo
SYRE Maintained by Wells Fargo -- Price Target Raised to $90 - GuruFocus
SYRE Initiated Coverage by Raymond James -- Strong Buy Rating Assigned - GuruFocus
Spyre Therapeutics: Strong SPY001 Data Sets Up A Catalyst-Rich 2026 (NASDAQ:SYRE) - Seeking Alpha
Deutsche Bank Adjusts Spyre Therapeutics PT to $88 From $55, Maintains Buy Rating - marketscreener.com
Spyre Sees Monotherapy Potential For UC Drug After Phase II Data - Citeline News & Insights
Positive Phase 2 Results Boost Spyre Therapeutics (SYRE) - GuruFocus
Spyre Therapeutics, Inc. (SYRE) Files 8-K with SEC Detailing Company Information and NASDAQ Listing - Minichart
Spyre Therapeutics, Inc. (SYRE) Discusses SPY001 Part A Induction Topline Results From SKYLINE Trial in Moderate-to-Severe Ulcerative ColitisSlideshow (NASDAQ:SYRE) 2026-04-14 - Seeking Alpha
SYRE Maintains by Jefferies -- Price Target Raised to $85.00 - GuruFocus
SYRE Stock Marks Best Session In About 3 Years — Here’s Why - Stocktwits
Spyre Therapeutics (SYRE) Launches $300M Public Offering to Fund Treatment Development - GuruFocus
Spyre Therapeutics (SYRE) Boosts Confidence in SPY001 Data - GuruFocus
Raymond James initiates Spyre stock with strong buy rating - Investing.com UK
Spyre (SYRE) Announces Stellar UC Treatment Trial, Hits 4-Year High - Insider Monkey
SYRE Maintained by Leerink Partners -- Price Target Raised to $1 - GuruFocus
Spyre Therapeutics (SYRE) Initiates $300 Million Stock Offering - GuruFocus
Spyre Therapeutics (SYRE) Reveals Promising Results in Ulcerativ - GuruFocus
Spyre Therapeutics stock falls on $300M stock offering - Investing.com
Spyre Therapeutics stock falls on $300M stock offering By Investing.com - Investing.com Canada
Spyre Therapeutics (NASDAQ: SYRE) seeks $300M via common stock offering; SPY001 shows strong Phase 2 topline - Stock Titan
Spyre Therapeutics launches $300 million stock offering - Investing.com
Spyre’s SPY-001 induces better outcomes in ulcerative colitis - BioWorld News
Raymond James initiates Spyre stock with strong buy rating By Investing.com - Investing.com South Africa
Spyre Therapeutics' Trial Data Boosts Stock by 23% - Intellectia AI
Spyre Therapeutics announces proposed public offering of its common stock - marketscreener.com
Spyre Therapeutics Inc suspends and terminates ATM prospectus for at-the-market offering effective April 13, 2026SEC filing - marketscreener.com
Spyre Therapeutics Announces Proposed Public Offering of its Common Stock - The Manila Times
Spyre Therapeutics IncSuspends And Terminates ATM Prospectus For At-The-Market Offering Effective April 13, 2026SEC Filing - TradingView — Track All Markets
Small U.S. Stocks Close Up; Spyre Therapeutics Leads Increases - Moomoo
SYRE Stock Jumps As Stifel Hikes Price Target To $92 - timothysykes.com
Spyre moves to raise $300M, with room to expand the sale to $345M - Stock Titan
Spyre Therapeutics (NASDAQ: SYRE) ends ATM prospectus, reports $741M cash - Stock Titan
SYRE Maintained by BTIG -- Price Target Raised to $98.00 - GuruFocus
Spyre Therapeutics Reports Positive Phase 2 SKYLINE Results - TipRanks
Jefferies raises Spyre stock price target to $85 on trial data - Investing.com Canada
Spyre Therapeutics Inc Stock (SYRE) Financials Data
Revenue
Net Income
Cash Flow
EPS
2.69%
0.25%
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