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45.68
8.20%
3.46
After Hours:
45.99
0.31
+0.68%
Spyre Therapeutics Inc stock is traded at $45.68, with a volume of 666.40K.
It is up +8.20% in the last 24 hours and up +4.10% over the past month.
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$42.22
Open:
$42.93
24h Volume:
666.40K
Relative Volume:
0.89
Market Cap:
$3.59B
Revenue:
$688.00K
Net Income/Loss:
$-135.82M
P/E Ratio:
-21.98
EPS:
-2.078
Net Cash Flow:
$-169.41M
1W Performance:
+6.08%
1M Performance:
+4.10%
6M Performance:
+192.63%
1Y Performance:
+151.54%
1-Day Range:
$42.68
$45.79
1-Week Range:
$40.91
$45.79
52-Week Range:
$10.91
$45.79
Spyre Therapeutics Inc Stock (SYRE) Company Profile
Name
Spyre Therapeutics Inc
Sector
Industry
Phone
(617) 651-5940
Address
221 CRESCENT STREET, WALTHAM
Compare SYRE vs VRTX, REGN, ALNY, ARGX, INSM
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
SYRE
Spyre Therapeutics Inc
|
45.68 | 3.32B | 688.00K | -135.82M | -169.41M | -2.078 |
VRTX
Vertex Pharmaceuticals Inc
|
454.97 | 113.96B | 12.07B | 3.95B | 3.19B | 15.33 |
REGN
Regeneron Pharmaceuticals Inc
|
749.47 | 78.41B | 14.34B | 4.50B | 3.77B | 41.56 |
ALNY
Alnylam Pharmaceuticals Inc
|
328.70 | 40.85B | 3.71B | 313.75M | 465.38M | 2.2571 |
ARGX
Argen X Se Adr
|
697.05 | 42.05B | 4.16B | 1.29B | 734.26M | 19.58 |
INSM
Insmed Inc
|
148.31 | 29.99B | 606.42M | -1.28B | -997.58M | -6.403 |
Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Dec-18-25 | Initiated | Mizuho | Outperform |
| Dec-17-25 | Initiated | Citigroup | Buy |
| Sep-26-25 | Initiated | Deutsche Bank | Buy |
| Apr-08-25 | Initiated | Leerink Partners | Outperform |
| Mar-18-25 | Initiated | Wolfe Research | Outperform |
| Sep-04-24 | Initiated | Wedbush | Outperform |
| Jul-16-24 | Initiated | Evercore ISI | Outperform |
| May-02-24 | Initiated | Robert W. Baird | Outperform |
| Mar-01-24 | Upgrade | Wells Fargo | Equal Weight → Overweight |
| Dec-20-23 | Initiated | BTIG Research | Buy |
| Dec-11-23 | Initiated | Guggenheim | Buy |
| Dec-11-23 | Initiated | Jefferies | Buy |
| May-04-20 | Initiated | Piper Sandler | Overweight |
| Mar-21-19 | Initiated | JP Morgan | Overweight |
| Sep-04-18 | Downgrade | Wells Fargo | Outperform → Market Perform |
| Apr-24-18 | Initiated | Evercore ISI | Outperform |
| Mar-14-18 | Reiterated | Needham | Buy |
View All
Spyre Therapeutics Inc Stock (SYRE) Latest News
Spyre Therapeutics (NASDAQ:SYRE) Sets New 12-Month HighHere's What Happened - MarketBeat
Spyre Therapeutics stock hits 52-week high at 45.79 USD By Investing.com - Investing.com Canada
Spyre Therapeutics, Inc. (NASDAQ:SYRE) Receives Average Rating of "Buy" from Brokerages - MarketBeat
Assessing Spyre Therapeutics (SYRE) Valuation After Strong One Year Return And Premium Price To Book Ratio - Yahoo Finance
Spyre Therapeutics (SYRE) Receives a Rating Update from a Top Analyst - The Globe and Mail
Spyre Therapeutics Completes First-in-Human Study of SPY001-001, De-risking Early Pipeline - TipRanks
SYRE Technical Analysis | Trend, Signals & Chart Patterns | SPYRE THERAPEUTICS INC (NASDAQ:SYRE) - ChartMill
US Market Recap: Can Spyre Therapeutics Inc lead its sector in growth - baoquankhu1.vn
Signal or Noise: What VR Adviser's Spyre Theraputics Buy Means for Fools - AOL.com
Signal or Noise: What VR Adviser's Spyre Theraputics Buy Means - The Motley Fool
VR Adviser Increases Stake in Spyre Therapeutics by 1 Million Shares - Intellectia AI
VR Adviser Increases Spyre Therapeutics Investment to $120.74MNews and Statistics - IndexBox
Signal or Noise: How VR Adviser's Acquisition of Spyre Therapeutics Impacts Fools - Bitget
Signal or Noise: What VR Adviser's Spyre Theraputics Buy Means for Fools - The Motley Fool
SYRE Stock Gets a Boost: Stifel Raises Price Target to $92 | SYR - GuruFocus
Spyre Therapeutics (NASDAQ:SYRE) Price Target Raised to $92.00 - MarketBeat
Stifel raises Spyre stock price target to $92 on TL1A potential - Investing.com Canada
Guggenheim Sticks to Its Buy Rating for Spyre Therapeutics (SYRE) - The Globe and Mail
Spyre: 'Strong Buy' As UC Program Moves Along And Q3 2026 RA Data Looms (NASDAQ:SYRE) - Seeking Alpha
Spyre Therapeutics (SYRE) Is Up 7.3% After Accelerating SPY072 Phase 2 POC TimelineHas The Bull Case Changed? - simplywall.st
BTIG Reiterates Buy Rating for Spyre Therapeutics (SYRE) with $7 - GuruFocus
Spyre Therapeutics (SYRE) Advances RA Sub-Study with Early Resul - GuruFocus
Leerink Maintains Outperform on Spyre Therapeutics, Inc. (SYRE) March 16, 2026 - Meyka
Deutsche Bank Raises Price Target for Spyre Therapeutics on Strong Cash Position - timothysykes.com
Spyre Therapeutics (NASDAQ:SYRE) Trading Up 9.3%Should You Buy? - MarketBeat
Spyre Therapeutics (NASDAQ:SYRE) Given Buy Rating at BTIG Research - MarketBeat
Leerink reiterates Spyre stock Outperform on faster trial timeline By Investing.com - Investing.com Canada
Spyre Therapeutics stock remains top 2026 pick at Guggenheim By Investing.com - Investing.com Canada
Spyre Announces Acceleration of Expected Topline Readout of SKYWAY Rheumatoid Arthritis Sub-study to Q3 2026 - Bitget
RA sub-study patient enrollment ends in Phase 2 SKYWAY trial as Spyre Therapeutics, Inc. eyes data release - Traders Union
Spyre Therapeutics, Inc. $SYRE Shares Acquired by HighVista Strategies LLC - MarketBeat
Aug Spikes: Can Spyre Therapeutics Inc lead its sector in growthRate Cut & Expert Verified Stock Movement Alerts - baoquankhu1.vn
Baker BROS. Advisors LP Buys 373,297 Shares of Spyre Therapeutics, Inc. $SYRE - MarketBeat
Spyre Therapeutics Stock Surges This Past Year as $10.5 Million Buy Lifts Stake to $78 Million - AOL.com
Transcript : Spyre Therapeutics, Inc. Presents at Leerink Global Healthcare Conference 2026, Mar-09-2026 08 - marketscreener.com
Market Review: Is RBNE stock risky to hold now2026 Fundamental Recap & Safe Entry Point Identification - baoquankhu1.vn
DLD Asset Management LP Acquires New Position in Spyre Therapeutics, Inc. $SYRE - MarketBeat
Spyre Therapeutics Announces Grants of Inducement Awards - The Manila Times
Weekly Earnings: What is the implied volatility of Spyre Therapeutics IncMarket Activity Recap & Community Driven Trade Alerts - baoquankhu1.vn
Patterns Watch: Can Spyre Therapeutics Inc grow without external fundingMarket Trend Review & Technical Confirmation Trade Alerts - baoquankhu1.vn
Trading Recap: Can Spyre Therapeutics Inc deliver consistent EPS growthVolume Spike & Weekly Top Performers Watchlists - baoquankhu1.vn
New Spyre hires get 46,600 stock options at $42.49 strike - Stock Titan
[EFFECT] Spyre Therapeutics, I... | SYRE SEC FilingForm EFFECT - Stock Titan
Assessing Spyre Therapeutics (SYRE) Valuation After A Year Of Strong Shareholder Returns - Yahoo Finance
Insider Selling: Cameron Turtle Sells 15,000 Shares of Spyre Therapeutics Inc (SYRE) - GuruFocus
Scott Burrows Sells 2,500 Shares of Spyre Therapeutics (NASDAQ:SYRE) Stock - MarketBeat
Spyre Therapeutics (NASDAQ:SYRE) CEO Sells $632,850.00 in Stock - MarketBeat
Spyre Therapeutics (SYRE) CFO sells 2,500 shares under 10b5-1 plan - Stock Titan
Investment Review: Is Spyre Therapeutics Inc a top pick in the sectorPortfolio Return Report & Verified Entry Point Signals - baoquankhu1.vn
Spyre Therapeutics CEO Sells 15,000 Shares - TradingView
Support Test: Can Spyre Therapeutics Inc lead its sector in growthPortfolio Profit Report & Daily Chart Pattern Signals - baoquankhu1.vn
Spyre Therapeutics Inc Stock (SYRE) Financials Data
Revenue
Net Income
Cash Flow
EPS
1.82%
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