15.65
price down icon3.40%   -0.55
after-market After Hours: 15.65
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Spyre Therapeutics Inc stock is traded at $15.65, with a volume of 431.14K. It is down -3.40% in the last 24 hours and down -1.51% over the past month. Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$16.20
Open:
$16.11
24h Volume:
431.14K
Relative Volume:
0.79
Market Cap:
$945.28M
Revenue:
$688.00K
Net Income/Loss:
$-170.19M
P/E Ratio:
-5.2872
EPS:
-2.96
Net Cash Flow:
$-154.68M
1W Performance:
-7.94%
1M Performance:
-1.51%
6M Performance:
-17.11%
1Y Performance:
-44.97%
1-Day Range:
Value
$15.64
$16.11
1-Week Range:
Value
$15.64
$17.13
52-Week Range:
Value
$10.91
$40.26

Spyre Therapeutics Inc Stock (SYRE) Company Profile

Name
Name
Spyre Therapeutics Inc
Name
Phone
(617) 651-5940
Name
Address
221 CRESCENT STREET, WALTHAM
Name
Employee
65
Name
Twitter
Name
Next Earnings Date
2024-11-07
Name
Latest SEC Filings
Name
SYRE's Discussions on Twitter

Compare SYRE with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SYRE
Spyre Therapeutics Inc
15.65 977.29M 688.00K -170.19M -154.68M -2.96
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
394.53 99.62B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
465.89 61.52B 2.46B -319.09M -52.09M -2.47
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
560.00 58.91B 14.21B 4.46B 3.56B 39.68
Biotechnology icon
ARGX
Argen X Se Adr
756.38 46.69B 3.06B 1.28B 447.35M 21.30
Biotechnology icon
ONC
Beone Medicines Ltd Adr
324.34 34.54B 3.81B -644.79M -669.77M -6.24

Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades

Date Action Analyst Rating Change
Apr-08-25 Initiated Leerink Partners Outperform
Mar-18-25 Initiated Wolfe Research Outperform
Sep-04-24 Initiated Wedbush Outperform
Jul-16-24 Initiated Evercore ISI Outperform
May-02-24 Initiated Robert W. Baird Outperform
Mar-01-24 Upgrade Wells Fargo Equal Weight → Overweight
Dec-20-23 Initiated BTIG Research Buy
Dec-11-23 Initiated Guggenheim Buy
Dec-11-23 Initiated Jefferies Buy
May-04-20 Initiated Piper Sandler Overweight
Mar-21-19 Initiated JP Morgan Overweight
Sep-04-18 Downgrade Wells Fargo Outperform → Market Perform
Apr-24-18 Initiated Evercore ISI Outperform
Mar-14-18 Reiterated Needham Buy
View All

Spyre Therapeutics Inc Stock (SYRE) Latest News

pulisher
Sep 12, 2025

Order flow analysis tools used on Spyre Therapeutics Inc.2025 AllTime Highs & Daily Volume Surge Trade Alerts - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

What’s next for Spyre Therapeutics Inc. stock price2025 Technical Overview & Safe Entry Trade Signal Reports - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Does Spyre Therapeutics Inc. fit your quant trading model2025 Market Outlook & Momentum Based Trading Signals - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Smart tools for monitoring Spyre Therapeutics Inc.’s price action2025 Trade Ideas & Consistent Growth Equity Picks - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Combining price and volume data for Spyre Therapeutics Inc.Market Performance Recap & AI Driven Stock Price Forecasts - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Wall Street Zen Upgrades Spyre Therapeutics (NASDAQ:SYRE) to "Hold" - MarketBeat

Sep 12, 2025
pulisher
Sep 12, 2025

Exit strategy if you’re trapped in Spyre Therapeutics Inc.Dollar Strength & Consistent Return Investment Signals - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Has Spyre Therapeutics Inc. formed a bullish divergenceWeekly Earnings Recap & Low Volatility Stock Suggestions - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Technical signs of recovery in Spyre Therapeutics Inc.July 2025 Decliners & Weekly Market Pulse Updates - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Spyre Therapeutics Inc. stock momentum explained2025 Historical Comparison & Growth Focused Investment Plans - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Can swing trading help recover from Spyre Therapeutics Inc. losses2025 Analyst Calls & Consistent Profit Trade Alerts - Newser

Sep 12, 2025
pulisher
Sep 12, 2025

Real time pattern detection on Spyre Therapeutics Inc. stockQuarterly Trade Review & Daily Risk Controlled Trade Plans - Newser

Sep 12, 2025
pulisher
Sep 11, 2025

What high frequency data says about Spyre Therapeutics Inc.Market Trend Review & Risk Managed Investment Strategies - Newser

Sep 11, 2025
pulisher
Sep 11, 2025

Should you hold or exit Spyre Therapeutics Inc. now2025 Market Overview & Safe Entry Point Identification - Newser

Sep 11, 2025
pulisher
Sep 11, 2025

Is Spyre Therapeutics Inc. forming a bottoming basePortfolio Return Report & Free Expert Approved Momentum Trade Ideas - Newser

Sep 11, 2025
pulisher
Sep 11, 2025

Adage Capital Partners GP L.L.C. Sells 226,800 Shares of Spyre Therapeutics, Inc. $SYRE - MarketBeat

Sep 11, 2025
pulisher
Sep 11, 2025

Volume spikes in Spyre Therapeutics Inc. stock – what they mean2025 Price Momentum & AI Enhanced Trading Alerts - Newser

Sep 11, 2025
pulisher
Sep 11, 2025

Visualizing Spyre Therapeutics Inc. stock with heatmapsJuly 2025 Drop Watch & Low Drawdown Investment Strategies - Newser

Sep 11, 2025
pulisher
Sep 11, 2025

News impact scoring models applied to Spyre Therapeutics Inc.Weekly Market Report & Daily Technical Stock Forecast Reports - Newser

Sep 11, 2025
pulisher
Sep 10, 2025

Published on: 2025-09-10 03:16:21 - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Regression analysis insights on Spyre Therapeutics Inc. performancePortfolio Update Report & High Yield Stock Recommendations - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Receives $53.40 Consensus Target Price from Analysts - MarketBeat

Sep 10, 2025
pulisher
Sep 10, 2025

Will Spyre Therapeutics Inc. bounce back from current supportWall Street Watch & Verified Momentum Stock Watchlist - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Price action breakdown for Spyre Therapeutics Inc.Weekly Profit Report & Technical Buy Zone Confirmations - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Will Spyre Therapeutics Inc. rebound enough to break evenInsider Buying & Expert-Curated Trade Recommendations - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Published on: 2025-09-10 00:27:42 - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Long term hold vs stop loss in Spyre Therapeutics Inc.July 2025 Decliners & Low Drawdown Investment Strategies - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Spyre Therapeutics Inc. stock trend forecastQuarterly Performance Summary & Community Trade Idea Sharing Platform - Newser

Sep 10, 2025
pulisher
Sep 10, 2025

Published on: 2025-09-09 23:39:40 - Newser

Sep 10, 2025
pulisher
Sep 09, 2025

Chart based exit strategy for Spyre Therapeutics Inc.Share Buyback & Real-Time Buy Signal Notifications - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

Can Spyre Therapeutics Inc. recover in the next quarterPortfolio Gains Summary & Safe Capital Growth Trade Ideas - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

What technical models suggest about Spyre Therapeutics Inc.’s comebackLayoff News & Community Consensus Stock Picks - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

Published on: 2025-09-09 07:10:47 - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

Tools to assess Spyre Therapeutics Inc.’s risk profileJuly 2025 Sentiment & Daily Volume Surge Trade Alerts - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

Can Spyre Therapeutics Inc. hit a new high this monthTrade Ideas & High Accuracy Swing Entry Alerts - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

How to build a custom watchlist for Spyre Therapeutics Inc.Weekly Market Report & Safe Entry Trade Signal Reports - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

Spyre Therapeutics Inc.’s volatility index tracking explainedPortfolio Profit Report & Smart Allocation Stock Tips - Newser

Sep 09, 2025
pulisher
Sep 09, 2025

what’s next for spyre therapeutics inc. stock priceMarket Growth Summary & Long-Term Safe Investment Ideas - Newser

Sep 09, 2025

Spyre Therapeutics Inc Stock (SYRE) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$36.36
price down icon 0.93%
$83.10
price down icon 3.56%
$27.82
price down icon 2.76%
$96.74
price down icon 7.26%
$145.93
price up icon 0.10%
biotechnology ONC
$324.34
price down icon 3.38%
Cap:     |  Volume (24h):