9.50
price down icon1.96%   -0.19
after-market After Hours: 9.50
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Prothena Corp Plc stock is traded at $9.50, with a volume of 403.74K. It is down -1.96% in the last 24 hours and up +8.08% over the past month. Prothena Corp PLC is a late-stage clinical biotechnology company that focuses on protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of devastating neurodegenerative and rare and peripheral amyloid diseases. Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery. The company's pipeline includes both wholly-owned and partnered programs like Prasinezumab, Coramitug (PRX004), BMS-986446 (PRX005), PRX019, TDP-43 CYTOPE, and PRX012-TfR, being developed for the potential treatment of Parkinson's disease, ATTR amyloidosis with cardiomyopathy, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases.
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Previous Close:
$9.69
Open:
$9.65
24h Volume:
403.74K
Relative Volume:
0.76
Market Cap:
$497.36M
Revenue:
$57.94M
Net Income/Loss:
$-151.18M
P/E Ratio:
-3.3789
EPS:
-2.8116
Net Cash Flow:
$-86.56M
1W Performance:
-4.71%
1M Performance:
+8.08%
6M Performance:
+5.91%
1Y Performance:
+47.63%
1-Day Range:
Value
$9.465
$9.84
1-Week Range:
Value
$9.465
$10.15
52-Week Range:
Value
$6.16
$11.80

Prothena Corp Plc Stock (PRTA) Company Profile

Name
Name
Prothena Corp Plc
Name
Phone
011-353-1-236-2500
Name
Address
77 SIR JOHN ROGERSON'S QUAY, BLOCK C, DUBLIN 2
Name
Employee
67
Name
Twitter
@ProthenaCorp
Name
Next Earnings Date
2026-08-03
Name
Latest SEC Filings
Name
PRTA's Discussions on Twitter

Compare PRTA vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
PRTA icon
PRTA
Prothena Corp Plc
9.50 512.54M 57.94M -151.18M -86.56M -2.8116
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
529.59 126.07B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
649.81 65.37B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
916.80 57.70B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
313.04 40.19B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
189.99 39.82B 742.00K -1.37B -1.07B -7.0731

Prothena Corp Plc Stock (PRTA) Upgrades & Downgrades

Date Action Analyst Rating Change
May-28-25 Downgrade BofA Securities Neutral → Underperform
May-27-25 Downgrade Cantor Fitzgerald Overweight → Neutral
May-27-25 Downgrade Jefferies Buy → Hold
May-27-25 Downgrade Oppenheimer Outperform → Perform
Dec-20-24 Initiated Chardan Capital Markets Buy
Jan-30-24 Downgrade BofA Securities Buy → Neutral
Dec-12-23 Initiated Deutsche Bank Buy
Apr-24-23 Initiated SVB Securities Outperform
Jan-27-23 Initiated Piper Sandler Overweight
Nov-04-22 Downgrade RBC Capital Mkts Outperform → Sector Perform
Sep-28-22 Upgrade BofA Securities Neutral → Buy
Nov-19-21 Initiated JMP Securities Mkt Outperform
Jun-18-21 Upgrade BofA Securities Underperform → Neutral
Jun-08-21 Reiterated Oppenheimer Outperform
May-26-21 Initiated Citigroup Buy
Feb-26-21 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-12-21 Upgrade Jefferies Hold → Buy
Feb-02-21 Upgrade BTIG Research Neutral → Buy
Dec-07-20 Initiated H.C. Wainwright Buy
Jul-09-20 Upgrade Oppenheimer Perform → Outperform
Nov-19-19 Upgrade Evercore ISI In-line → Outperform
May-21-18 Downgrade Barclays Equal Weight → Underweight
Apr-23-18 Downgrade Jefferies Buy → Hold
Apr-05-18 Reiterated Barclays Overweight
Nov-20-17 Downgrade Wedbush Outperform → Neutral
Sep-29-17 Reiterated BTIG Research Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Aug-17-17 Initiated Evercore ISI Outperform
Jul-11-17 Initiated Jefferies Buy
Apr-12-17 Initiated Cantor Fitzgerald Overweight
Apr-12-17 Initiated Piper Jaffray Overweight
Mar-02-17 Initiated Instinet Buy
Dec-21-16 Initiated SunTrust Buy
Nov-03-16 Initiated Deutsche Bank Buy
Aug-04-16 Reiterated Barclays Overweight
May-13-16 Initiated Barclays Overweight
Feb-19-16 Reiterated Wedbush Outperform
Jan-21-16 Initiated Credit Suisse Outperform
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Prothena Corp Plc Stock (PRTA) Latest News

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Jul 01, 2026

PRTAProthena Corp Plc Options - Finviz

Jul 01, 2026
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Jun 27, 2026

Price to sales forward of Prothena Corp. Plc – MUN:0PT - TradingView

Jun 27, 2026
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Jun 27, 2026

Enterprise value to revenue forward of Prothena Corporation plc – NASDAQ:PRTA - TradingView

Jun 27, 2026
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Jun 27, 2026

Enterprise value to EBIT forward of Prothena Corporation plc – NASDAQ:PRTA - TradingView

Jun 27, 2026
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Jun 27, 2026

Price to book forward of Prothena Corp. Plc – MUN:0PT - TradingView

Jun 27, 2026
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Jun 26, 2026

Enterprise value to EBITDA forward of Prothena Corp. Plc – MUN:0PT - TradingView

Jun 26, 2026
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Jun 26, 2026

Enterprise value to revenue forward of Prothena Corp. Plc – MUN:0PT - TradingView

Jun 26, 2026
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Jun 26, 2026

Prothena Corp, Parkinson antibody program draws attention for the stock - AD HOC NEWS

Jun 26, 2026
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Jun 26, 2026

Prothena Corp. Plc Actuals & Estimates (NASDAQ:PRTA) - TradingView

Jun 26, 2026
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Jun 26, 2026

Prothena Corp. Plc Actuals & Estimates (DUS:0PT) - TradingView

Jun 26, 2026
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Jun 25, 2026

Prothena Corp. Plc Actuals & Estimates (SWB:0PT) - TradingView

Jun 25, 2026
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Jun 25, 2026

PRTA Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 25, 2026

0PT Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 24, 2026

Prothena Corporation PLC (PRTA) Technical Analysis: Support, Resistance, Indicators & Moving Averages - TradingKey

Jun 24, 2026
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Jun 23, 2026

Prothena Corporation Plc (NASDAQ:PRTA) About To Shift From Loss To Profit - Moomoo

Jun 23, 2026
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Jun 22, 2026

Prothena Corp plc strategy in focus, shares watched against biotech peers - AD HOC NEWS

Jun 22, 2026
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Jun 18, 2026

Prothena Corporation PLC (PRTA) Dividends & Stock Splits: Historical Payouts and Event Timeline - TradingKey

Jun 18, 2026
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Jun 18, 2026

Prothena Corporation PLC (PRTA) Shareholder Structure: Major Shareholders & Institutional Holdings - TradingKey

Jun 18, 2026
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Jun 18, 2026

Prothena Corporation PLC (PRTA) Revenue Breakdown: Business Segments, Regional Revenue & Profit Contribution - TradingKey

Jun 18, 2026
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Jun 17, 2026

Prothena Corporation PLC (PRTA) Risk Assessment: Volatility, Financial Risk & Investment Risk - TradingKey

Jun 17, 2026
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Jun 17, 2026

Price-Driven Insight from (PRTA) for Rule-Based Strategy - Stock Traders Daily

Jun 17, 2026
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Jun 06, 2026

(PRTA) Price Dynamics and Execution-Aware Positioning - Stock Traders Daily

Jun 06, 2026
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May 29, 2026

PRTA Q1 2026 Earnings: Surprise EPS Beat Driven by Milestone Revenue, Stock Edges HigherDownward Estimate Revision - The Legal Advocate

May 29, 2026
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May 26, 2026

(PRTA) as a Liquidity Pulse for Institutional Tactics - Stock Traders Daily

May 26, 2026
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May 25, 2026

Penbrook Management LLC's Prothena Corp PLC(PRTA) Holding History - GuruFocus

May 25, 2026
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May 15, 2026

Prothena (NASDAQ: PRTA) investors approve board, KPMG and executive pay - Stock Titan

May 15, 2026
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May 15, 2026

Rubric Capital and David Rosen disclose 9.29% stake in Prothena (PRTA) - Stock Titan

May 15, 2026
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May 14, 2026

Prothena Corp plc stock (IE00B91XRN20): Biotech investor focus amid pipeline updates - AD HOC NEWS

May 14, 2026
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May 14, 2026

Number of shareholders of Prothena Corp. Plc – DUS:0PT - TradingView

May 14, 2026
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May 12, 2026

PRTA Stock Price, Quote & Chart | PROTHENA CORP PLC (NASDAQ:PRTA) - ChartMill

May 12, 2026
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May 11, 2026

William Scully reports 10.27% stake in PROTHENA (NASDAQ: PRTA) - Stock Titan

May 11, 2026
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May 11, 2026

Prothena Corp. Down Over 9%, on Pace for Largest Percent Decrease Since May 2025 -- Data Talk - Moomoo

May 11, 2026
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May 11, 2026

Earnings Beat: Prothena Corporation plc Just Beat Analyst Forecasts, And Analysts Have Been Updating Their Models - Yahoo Finance

May 11, 2026
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May 09, 2026

Prothena (PRTA) Heavy US$244 Million Annual Loss Tests Bullish Profitability Narratives - Sahm

May 09, 2026
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May 08, 2026

Prothena Posts Q1 Earnings as Revenues Surge on Milestone Payment - Yahoo Finance

May 08, 2026
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May 08, 2026

Prothena (PRTA) Highlights Progress in Parkinson's Research and Collaborations - GuruFocus

May 08, 2026
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May 08, 2026

Citizens raises Prothena stock price target on milestone payment By Investing.com - Investing.com UK

May 08, 2026
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May 08, 2026

Prothena (PRTA) Revises 2026 Cash Outlook and Operating Expenses - GuruFocus

May 08, 2026
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May 07, 2026

Prothena (NASDAQ:PRTA) Smashes Q1 Estimates on $50 Million Milestone Payment, Shares Steady - ChartMill

May 07, 2026
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May 07, 2026

Prothena: Q1 Earnings Snapshot - marketscreener.com

May 07, 2026
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May 07, 2026

Milestone revenue lifts Prothena (NASDAQ: PRTA) cash and pipeline - Stock Titan

May 07, 2026
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May 07, 2026

Prothena (NASDAQ: PRTA) posts $32.7M Q1 profit and lifts 2026 cash outlook - Stock Titan

May 07, 2026
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May 07, 2026

A $50M Novo milestone reshaped Prothena’s 2026 cash outlook - Stock Titan

May 07, 2026
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May 07, 2026

Tranche Update on Prothena Corporation plc's Equity Buyback Plan announced on February 27, 2026. - marketscreener.com

May 07, 2026
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Apr 30, 2026

Prothena to Report First Quarter 2026 Financial Results on May 7 - ChartMill

Apr 30, 2026
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Apr 29, 2026

3 Growth Companies Insiders Are Eager To Hold - Sahm

Apr 29, 2026
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Apr 28, 2026

Prothena (NASDAQ:PRTA) Shares Up 5.9%Time to Buy? - MarketBeat

Apr 28, 2026
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Apr 27, 2026

FDA Fast Track granted to Phase 3 drug for ATTR-CM - Stock Titan

Apr 27, 2026
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Apr 27, 2026

Prothena Announces Novo Nordisk Obtains Fast Track Designation from the U.S. FDA for Coramitug (PRX004) in ATTR Amyloidosis with Cardiomyopathy - The Joplin Globe

Apr 27, 2026
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Apr 26, 2026

Prothena authorizes up to $100 million share repurchase plan - MSN

Apr 26, 2026
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Apr 23, 2026

PRTA SEC FilingsProthena 10-K, 10-Q, 8-K Forms - Stock Titan

Apr 23, 2026

Prothena Corp Plc Stock (PRTA) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Prothena Corp Plc Stock (PRTA) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
SCULLY WILLIAM P
10% Owner
Jun 11 '26
Buy
8.17
125,000
1,021,225
1,061,000
$111.54
price down icon 0.05%
$56.92
price down icon 1.47%
$35.39
price up icon 0.74%
ONC ONC
$309.46
price up icon 3.97%
$81.80
price up icon 2.56%
$189.99
price up icon 0.40%
Cap:     |  Volume (24h):